专利号:US-2012177593-A1 优先权日:2009-07-20 标 题 :Synthesis of dendrimer conjugates 发明人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH 权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN 摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.
专利号:US-2023339844-A1 优先权日:2020-09-17 标题:A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof 发明人:MAHAPATRA TRIDIB; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER G M; MAL SANJIB; SHARMA RAJU 权利人:PI INDUSTRIES LTD; PI INDUSTRIES LTD 摘要:The present invention disclosed a process for the synthesis of compound of formula (Z) or a salt thereof, n n n n n n n n n n wherein, R, R 1 , R 2 , R 3 and R 10 are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).
专利号:US-2023339906-A1 优先权日:2020-09-26 标 题 :A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof 发明人:SYTHANA SURESH KUMAR; NAGLE PRAMOD; KUMAR VIJAY KUMAR; KANAWADE SHRIKANT BHAUSAHEB; CHANDRE TUKARAM NIVRUTTI; THUBE VINAYAK KISAN; PATIL PRADEEP PRAKASH; SHUKLA SHALINI; SHENDE KANTILAL BALU; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER G M 权利人:PI INDUSTRIES LTD; PI INDUSTRIES LTD 摘要:The present invention discloses a process for the synthesis of compound of formula (VII) or a salt thereof,wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).
专利号:EP-0343716-A1 优先权日:1988-05-23 标 题 :Process for synthesis of a beta-lactam carbapenem intermediate 发明人:LOEWE MALLORY F; CVETOVICH RAYMOND; HAZEN GEORGE G 权利人:MERCK & CO INC 摘要:A process is described for the synthesis of 3(S)-4(R)-3-[1(S)-hydroxyethyl]-4-(alkoxycarbonylÂmethyl)-azetidin-2-one (II) which is a useful intermediate in the synthesis of carbapenem antibiotics.
专利号:US-5037974-A 优先权日:1988-05-23 标题:Cyclization process for synthesis of a beta-lactam carbapenem intermediate 发明人:LOEWE MALLORY F; CVETOVICH RAYMOND; HAZEN GEORGE G 权利人:MERCK & CO INC 摘要:A process is described for the synthesis of 3(S)-4(R)-3-[1(S)-hydroxyethyl]-4-(alkoxycarbonylmethyl)-azetidin-2-one (II) which is a useful intermediate in the synthesis of carbapenem antibiotics.
专利号:US-RE41366-E 优先权日:2001-06-15 标 题 :Total synthesis of galanthamine, analogues and derivatives thereof 发明人:THAL CLAUDE; GUILLOU CATHERINE; BEUNARD JEAN-LUC; GRAS EMMANUEL; POTIER PIERRE 权利人:CT NAT DEL LA RECH SCIENT CNRS 摘要:The invention relates to a method for the synthesis of galanthamine, the derivatives and analogues thereof of formula (1) where R 1 =a hydrogen atom, R 2 =a hydroxy group, R 1 and R 2 together form â•?O, R 3 , R 4 , and R 5 independently=a hydrogen atom, a hydroxy group or a (C 1 -C 2 )alkoxy group, R 6 â•?H, (C 1 -C 12 )alkyl, (CH 2 ) n NR 7 R 8 , or —(CH 2 ) n N + R 7 R 8 R 9 where n=1 to 12, Z=two hydrogen atoms, or an oxygen atom and X=an oxygen, sulphur or nitrogen atom, or a —SO, —SO 2 , or —NR 6 group where R 6 is as defined above or is an amine protecting group.
[参考文献]: Ming-Kung Yeh, Et Al. Studies On A Novel Gelatin Sponge: Preparation And Characterization Of Cross-Linked Gelatin Scaffolds Using 2-Chloro-1-Methylpyridinium Iodide As A Zero-Length Cross-Linker. J Biomater Sci Polym Ed. 2012;23(7):973-90. [参考文献]: Qizhi Hu, Et Al. Complete Regression Of Breast Tumour With A Single Dose Of Docetaxel-Entrapped Core-Cross-Linked Polymeric Micelles. Biomaterials. 2015:53:370-8. [参考文献]: W Keese, Et Al. [参考文献]: Biol Chem Hoppe Seyler. 1985 Dec;366(12):1093-5.
合成参考文献
摘要:Merck Index - O'Neil MJ, Heckelman PE, Dobbelaar PH, Roman KJ (eds). The Merck Index, An Encyclopedia of Chemicals, Drugs, and Biologicals, 15th Ed. Cambridge, UK: The Royal Society of Chemistry, 2013. 摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2014). 摘要:Begtrup, M., Science of Synthesis, (2004) 13, 838. 摘要:Spitzner, D., Science of Synthesis, (2005) 15, 245. 摘要:Berlinck, R. G. S.; Kossuga, M. H.; Nascimento, A. M., Science of Synthesis, (2005) 18, 1087.