CAS: 13981-57-2; Sulfur-32 Atom

专利信息

专利号:US-11773118-B2
优先权日:2019-02-21
标 题:Methods of making high enantioselective secondary alcohols
发明人：YU CHENG-DER TONY; HSIEH YIH-HUANG; LIN SHU-YI; CHAO CHIN-SHENG; HSIEH YIN-CHENG; LAI MING-TAIN
权利人:OBI PHARMA INC
摘要:A new process to synthesis of compound OBI-3424 R-form and S-form products is provided. The “R-formâ€? compound OBI-3423 was first synthesized with 48% overall yield from compound OBI-3424-5 by installation of the labile phosphate motif at later stage. The stereo chemistry is established by 5 steps chemo-enzyme combination synthesis to afford 99% optical purity. After then, the “S-formâ€? compound OBI-3424 is prepared with improving overall yield of 54% from compound OBI-3424-5. The stereo chemistry is established by 4 steps combination of chemo-enzyme synthesis with excellent optical purity of 99%.

专利号:US-2011071229-A1
优先权日:2009-09-21
标 题:Synthetic Gas Recycle Apparatus and Methods
发明人：ROBERTSON MARK K; LIOU GWO-JANG ABRAHAM
权利人:SYNTHESIS ENERGY SYSTEMS INC
摘要:Processes and apparatuses for synthesizing a hydrocarbon by reacting a carbon-containing feedstock with an oxygen-containing gas stream having a greater molar ratio of oxygen than the feedstock to produce a first synthetic gas comprising carbon monoxide and hydrogen, reacting the first synthetic gas in a shift reaction zone to produce a shifted synthetic gas, optionally but preferably blending a recycled synthetic gas with the shifted synthetic gas to produce a second synthetic gas, reacting the second synthetic gas with a catalyst in a synthesis reaction zone to produce hydrocarbon(s) and a purge gas, passing the purge gas through a separation zone to produce a hydrogen-containing permeate stream having an increased hydrogen molar ratio compared to the purge gas and a methane-containing non-permeate stream having an increased methane molar ratio compared to the purge gas, and reacting the methane-containing non-permeate stream in a reformation zone to produce the recycled synthetic gas.

专利号:US-9580409-B2
优先权日:2011-11-07
标 题:Modulators of opioid receptors and methods of use thereof
发明人：MALCOLM SCOTT; BOWEN CARRIE; MELNICK LAURENCE; XIE LINGHONG
权利人:SUNOVION PHARMACEUTICALS INC; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as pain, neurological disorders, psychiatric disorders, and neuromuscular disorders. Compounds provided herein modulate the activity of opioid receptor (e.g., μ-opioid receptor) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:US-2025312367-A1
优先权日:2022-05-13
标 题:Oligonucleotides having a synthetic backbone and synthesis thereof
发明人：LI ZHEN; CHIRUTA CHANDRAMOULI; CHENG BO; NUMA MEHDI MICHEL DJAMEL; AZIMIOARA MIHAI; OLSSON CHASE ROBERT; ZHU RUI; FONG KIN
权利人:ADARX PHARMACEUTICALS INC
摘要:Provided herein are oligonucleotide-containing compounds, methods of delivering the compounds, and methods of treating diseases, disorders, and symptoms (e.g., central nervous system diseases, disorders, and symptoms) in a subject using the compounds.

专利号:WO-2014004625-A1
优先权日:2012-06-26
标题:Microorganisms for producing ethylene glycol using synthesis gas
发明人：OSTERHOUT ROBIN E; BURGARD ANTHONY P; BURK MARK J
权利人:GENOMATICA INC
摘要:The invention provides a non-naturally occurring microbial organism containing an ethylene glycol pathway, wherein the pathway includes at least one exogenous nucleic acid encoding an ethylene glycol pathway enzyme expressed in a sufficient amount to produce ethylene glycol. The non-naturally occurring microorganisms of the invention can express exogenous nucleic acids that catalyze the fixation of C02 or CO to ethylene glycol. The microorganisms of the invention can further include enzymes to generate energy and reducing equivalents from methanol, syngas and other gaseous sources. The invention additionally provides methods of using such microbial organisms to produce ethylene glycol, by culturing a non-naturally occurring microbial organism containing an ethylene glycol pathway under conditions and for a sufficient period of time to produce ethylene glycol.

专利号:US-11371063-B2
优先权日:2014-07-11
标题:Microorganisms and methods for the production of butadiene using acetyl-coA
发明人：PHARKYA PRITI; BURGARD ANTHONY P; BURK MARK J
权利人:GENOMATICA INC
摘要:The invention provides non-naturally occurring microbial organisms containing butadiene or 2,4-pentadienoate pathways comprising at least one exogenous nucleic acid encoding a butadiene or 2,4-pentadienoate pathway enzyme expressed in a sufficient amount to produce butadiene or 2,4-pentadienoate. The organism can further contain a hydrogen synthesis pathway. The invention additionally provides methods of using such microbial organisms to produce butadiene or 2,4-pentadienoate by culturing a non-naturally occurring microbial organism containing butadiene or 2,4-pentadienoate pathways as described herein under conditions and for a sufficient period of time to produce butadiene or 2,4-pentadienoate. Hydrogen can be produced together with the production of butadiene or 2,4-pentadienoate.