专利号:WO-9832790-A1 优先权日:1997-01-27 标 题:Porous articles with surface functionality and uses thereof 发明人:KOONTZ STEVEN L; DEVIVAR RODRIGO V; FABRICANT JILL D; GOLDKNOPF IRA L 权利人:FLOWGENIX CORP; KOONTZ STEVEN L; DEVIVAR RODRIGO V; FABRICANT JILL D; GOLDKNOPF IRA L 摘要:Porous organic articles having no surface functionality may be treated by remote plasma discharge to introduce oxygen or nitrogen atoms directly bonded to the surface of the article, including the interstitial surface. These oxygen and nitrogen atoms provide chemical handles through which a variety of useful moieties can be bonded to the article. Modified porous organic articles are useful in the solid phase synthesis of biomolecules when nucleosides, amino acids, or their derivatives are bonded directly or indirectly to the nitrogen or oxygen atoms. Alternatively, porous solid supports can be treated to introduce chromatographically active groups, such as an anion exchanger, a cation exchanger, an hydrophobic group, a hydrazide group, a reactive group of covalent bond formation through protein amino groups, a substituent group for reversed phase chromatography, and a substituent group for chiral chromatography. Moreover, surface-functionalized porous articles comprising an immobilized diagnostic agent can be used for diagnosing or monitoring patient conditions and diseases.
专利号:EP-3049072-A1 优先权日:2013-09-25 标 题:Synthesis of delta 12-pgj3 and related compounds
专利号:WO-2015048268-A1 优先权日:2013-09-25 标题 :Synthesis of delta 12-pgj3 and related compounds
专利号:TW-568914-B 优先权日:1996-12-23 标题 :Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
专利号:CN-1242007-A 优先权日:1996-12-23 标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising such compounds, and methods of inhibiting beta amyloid peptide release and/or its synthesis using such compounds
专利号:PT-951466-E 优先权日:1996-12-23 标题:CYTOALQUIL COMPOUNDS, LACTAMA, LACTONE AND RELATED, PHARMACEUTICAL COMPOSITIONS UNDERSTANDING THE SAME, AND METHODS FOR INHIBITING Î’-AMYLOID PEPTIDE RELEASE AND / OR ITS SYNTHESIS BY THE USE OF SUCH COMPOUNDS