CAS: 10419-77-9; Diethyl (Iodomethyl)Phosphonate

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3167-63-3 66197-72-6 1067-87-4

上下游产品

CAS号31618-90-3 对甲苯磺酰氧甲基膦酸二乙酯 | CAS号3084-40-0 二乙基(羟甲基)磷酸酯 | CAS号75-11-6 二碘甲烷 | CAS号122-52-1 亚磷酸三乙酯 | CAS号38066-16-9 二乙基(苯基硫代甲基)磷酸酯 | CAS号194999-08-1 1-diethoxyphosp... | CAS号78-38-6 乙基膦酸二乙酯 | CAS号1660-94-2 四乙基亚甲基二磷酸酯 | CAS号683-08-9 甲基膦酸二乙酯 | CAS号1068-00-4 (4-oxo-pentyl)-... | CAS号1068-07-1 1-辛基膦酸二乙酯 | CAS号16165-66-5 己基膦酸二乙酯 | CAS号82101-87-9 oxo-2-phenyl-3 ... | CAS号3453-00-7 (2-氧代-2-苯乙基)膦酸二乙酯

📜对甲苯磺酰氧甲基膦酸二乙酯置于sodium Iodide体系中,用 丙酮 用作溶剂,化学反应 24.0H,反应生成碘甲基膦酸二乙酯
参考文献:通过铜(I)-催化的α,β-不饱和砜的1,4-共轭甲硅烷基化和随后的julia-Kocienski 烯烃不对称合成手性1,3-二取代烯丙基硅烷
标题:通过铜(I)-催化的α,β-不饱和砜的1,4-共轭甲硅烷基化和随后的julia-Kocienski 烯烃不对称合成手性1,3-二取代烯丙基硅烷
摘要:手性 1,3-二取代烯丙基硅烷的一般合成是通过铜 (I) 催化的 α,β-不饱和砜的不对称 1,4-共轭硅烷化和随后的 Julia-Kocienski 烯化建立的.通过修饰 Mcquade 的 Nhc 配体,以高对映选择性实现了具有广泛底物范围的催化不对称共轭硅烷化.以下julia-Kocienski 烯化在室温下顺利进行,以中等产率提供一系列手性烯丙基硅烷.更有趣的是,成功实现了具有高合成效率的一锅不对称合成.在醛和醛亚胺的不对称烯丙基化中证明了制备的手性 1,3-二取代烯丙基硅烷的效用.最后,在手性醛的不对称烯丙基化中观测到了一个有趣的"匹配和错配"现象.
Doi:10.1002/cjoc.202100101

专利信息

专利号:US-5852198-A
优先权日:1996-04-03
标题 :Wittig reagents and method for preparing α,β-unsaturated phosphonates
发明人：XU YIBO; FLAVIN MICHAEL T; XU ZE-QI
权利人:MEDICHEM RES INC
摘要:Wittig-type reagents and methods of preparation and use thereof for preparing alpha , beta -unsaturated phosphonate esters from aldehydes and ketones are disclosed. The Wittig-type reagents have the following formulae: I II wherein X represents triflate, halide, BF4, SbF6, or ClO4; R1 represents alkyl, aryl or arylalkyl; and R2 represents alkyl, aryl or arylalkyl, provided that R1 and R2 not represent phenyl at the same time. The Wittig reagent diethyl phosphono-methylidenetriphenylphosphorane (1b) has been successfully synthesized for the first time via its phosphonium triflate salt (4a), by treating diethyl phosphonomethyltriflate with triphenylphosphine according to the disclosed method. The procedure has been applied to the synthesis of other new Wittig-type reagents such as phosphoranes and phosphonium salts. The new Wittig reagents thus synthesized were treated with various aldehydes and an activated ketone, affording the corresponding alpha , beta -unsaturated phosphonates, saturated phosphonates or phosphoric acids. Triphenylphosphorane 1b and triphenylphosphonium 4a led to both cis and trans isomers with the latter being predominant, while trans isomers were almost exclusively formed when tributyl reagents (1c and 4d) were used.

专利号:US-9096624-B2
优先权日:2009-06-01
标 题:Amino pyrimidine anticancer compounds
发明人：CREW ANDREW P; SHERMAN DAN; APPARI RAMA DEVI; CHEN XIN; CHILUKURI RAMESH; DONG HANQING; FERRARO CATERINA; FOREMAN KENNETH; GUPTA RAMESH C; LI AN-HU; STOLZ KATHRYN M; VOLK BRIAN; ZAHLER ROBERT
权利人:OSI PHARMACEUTICALS LLC
摘要:Compounds of Formula 1, as shown below and defined herein: n n n n n n n n n n n n and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by FAK.