月桂酸置于potassium Hydroxide体系中,化学反应生成月桂酸钾 参考文献:Fatty Acid Potassium Had Beneficial Bactericidal Effects And Removed Staphylococcus Aureus Biofilms While Exhibiting Reduced Cytotoxicity Towards Mouse Fibroblasts And Human Keratinocytes 标题:Fatty Acid Potassium Had Beneficial Bactericidal Effects And Removed Staphylococcus Aureus Biofilms While Exhibiting Reduced Cytotoxicity Towards Mouse Fibroblasts And Human Keratinocytes 摘要:伤口经常会被细菌感染或污染.植酸钾(c18:1K),一种脂肪酸钾,导致金黄色葡萄球菌和大肠杆菌数量在10分钟内减少了>4个对数菌落形成单位(cfu)/毫升,并在1分钟内将难辨梭菌数量减少了>2个对数cfu/毫升.C18:1K(去除比例:90.3%)在去除金黄色葡萄球菌生物膜方面明显比合成表面活性剂十二烷基硫酸钠(sles)(74.8%,P < 0.01)和十二烷基硫酸钠(sls)(78.0%,P < 0.05)更有效.在水溶性四唑盐(wst)测定中,C18:1K中的小鼠成纤维细胞(balb/3T3克隆a31)(相对存活率与对照组比:102.8%)的存活率明显高于sles(30.1%)或sls(18.1%,P < 0.05).在乳酸脱氢酶(ldh)泄漏测定中,C18:1K(相对泄漏与对照组比:108.9%)与从小鼠成纤维细胞泄漏的ldh比sles或sls(分别为720.6%和523.4%,P < 0.05)相关联.植酸钾对金黄色葡萄球菌,大肠杆菌,蜡样芽孢杆菌和难辨梭菌等各种物种表现出杀菌效果;去除的金黄色葡萄球菌生物膜材料显著多于sles和sls;并保持了成纤维细胞的生存能力;因此,它可能对伤口清洁和周围皮肤有用. Doi:10.3390/ijms20020312
专利信息
专利号:EP-2354120-A1 优先权日:2003-08-20 标题 :Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof 发明人:GALLOP MARK A; YAO FENMEI; LUDWIKOW MARIA J; PHAN THU; PENG GE 权利人:XENOPORT INC 摘要:The present invention relates to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-tluorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The present invention also relates to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
专利号:WO-9412651-A1 优先权日:1992-12-01 标题 :Enzymatic synthesis of sugar alcohol esters 发明人:BARFOED MARTIN; SKAGERLIND JAN PETER 权利人:NOVO NORDISK AS; BARFOED MARTIN; SKAGERLIND JAN PETER 摘要:A method of preparing a compound of the general formula (I): R1-COO-X-O-R2, wherein R1-CO is the acyl group of a carboxylic acid which may be saturated or unsaturated, O-X-O is a saccharide moiety or a sugar alcohol moiety corresponding to a saccharide or a sugar alcohol of the general formula X(OH)¿2?, and R?2¿ is hydrogen, acetyl, or an alkyl group.
专利号:US-5244940-A 优先权日:1986-06-13 标题 :Process for agglomerating a latex, agglomerated latex obtained and its application to the modification of thermoplastic matrices to make them impact-resistant 发明人:RIESS GERARD; THYEBAULT HERVE 权利人:CHARBONNAGES STE CHIMIQUE 摘要:The agglomeration of a latex of a polymer chosen from elastomers and thermoplastic resins is performed by mixing the latex to be agglomerated with an agglomerating latex consisting of: (A) a polymer chosen from elastomers and thermoplastic resins; and (B) a nonionic surface-active agent consisting of a block polymer containing at least one polyoxyethylene block and at least one block of a polymer chosen from vinyl, diene and acrylic and methacrylic ester polymers, the said agglomerating latex being produced by the synthesis of the polymer defined under (A) during which (B) has been employed as a surfactant. The polyoxyethylene-polystyrene-polyoxyethylene triblock polymer may be mentioned among the surface-active agents (B).
专利号:US-5262455-A 优先权日:1986-06-13 标题:Process for agglomerating a latex, agglomerated latex obtained and its application of the modification of thermoplastic matrices to make them impact-resistant 发明人:RIESS GERARD; THYEBAULT HERVE 权利人:CHARBONNAGES STE CHIMIQUE 摘要:The agglomeration of a latex of a polymer chosen from elastomers and thermoplastic resins is performed by mixing the latex to be agglomerated with an agglomerating latex consisting of: (A) a polymer chosen from elastomers and thermoplastic resins; and (B) a nonionic surface-active agent consisting of a block polymer containing at least one polyoxyethylene block and at least one block of a polymer chosen from vinyl, diene and acrylic and methacrylic ester polymers, the said agglomerating latex being produced by the synthesis of the polymer defined under (A) during which (B) has been employed as a surfactant. The polyoxyethylene-polystyrene-polyoxyethylene triblock polymer may be mentioned among the surface-active agents (B).
专利号:US-7432031-B2 优先权日:2005-03-22 标 题:Toner for electrostatic charge developing, production method thereof, developer for electrostatic charge developing using the same, and image forming method 发明人:MIZUTANI NORIYUKI; MAEHATA HIDEO; HAMANO HIROKAZU; TANAKA HIROYUKI; KITAGAWA SOICHIRO; IGUCHI MOEGI 权利人:FUJI XEROX CO LTD 摘要:A toner for electrostatic charge developing prepared by a production method including aggregating one or more kind of particles in a raw material dispersion including the particles to form aggregated particles, and coalescing the aggregated particles by heating. At least one kind of the particles is resin particles including an amorphous polyester resin synthesized by copolymerizing one or more polyvalent carboxylic acids and two or more polyhydric alcohols; at least one of the polyvalent carboxylic acids is polyvalent carboxylic acid having a sulfonic acid group; two of the polyhydric alcohols are an ethylene oxide adduct of bisphenol A and a propylene oxide adduct of bisphenol A; and the following equation is satisfied:n n10/90≦ BPA ( EO )/ BPA ( PO )≦90/10.n n In the equation, BPA(EO) represents a total mole amount of the ethylene oxide adduct of bisphenol A used in synthesis of the amorphous polyester resin, and BPA(PO) represents a total mole amount of the propylene oxide adduct of bisphenol A used in synthesis of the amorphous polyester resin.
专利号:US-8372881-B2 优先权日:2005-06-20 标题 :Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use 发明人:ZERANGUE NOA; JANDELEIT BERND; LI YUNXIAO; GALLOP MARK A 权利人:XENOPORT INC; ZERANGUE NOA; JANDELEIT BERND; LI YUNXIAO; GALLOP MARK A 摘要:Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid, pharmaceutical compositions thereof, methods of making prodrugs of trans-4-(aminomethyl)-cyclohexane-carboxylic acid, and methods of using prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid and pharmaceutical compositions thereof to treat or prevent various diseases or disorders are disclosed. Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid and pharmaceutical compositions thereof suitable for oral and topical administration and for administration using sustained release dosage forms are also disclosed.
摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118 摘要:Final Report 04/2019 Available from CIR 参考文献:10.1140/epje/i2003-10076-8 摘要:Cuppo FL, Gómez SL, Figueiredo Neto AM. Effect of the concentration of magnetic grains on the linear-optical-absorption coefficient of ferrofluid-doped lyotropic mesophases: deviation from the Beer-Lambert law. Eur Phys J E Soft Matter. 2004 Apr;13(4):327–33. doi: 10.1140/epje/i2003-10076-8. 参考文献:10.1007/bf00231812 摘要:Samorì B, Lenaz G, Battino M, Marconi G, Domini I. On coenzyme Q orientation in membranes: A linear dichroism study of ubiquinones in a model bilayer. The Journal of Membrane Biology. 1992 Jun;128(3):193–203. doi: 10.1007/bf00231812.