CAS: 97945-19-2; Rel-(1R,6R)-6-Aminocyclohex-3-Ene-1-Carboxylic Acid

相似化合物

945935-64-8 54162-90-2 213986-70-0

上下游产品

6-carbamoylcyclohex-3-enecarboxylic acid 1,2,3,6-tertahydrophthalimide trans-2-Carboxamid°Cyclohex-4-enecarboxylic acidquinazolin-11-onecis-1,4,4a,6,7,8,9,11a-°Ctahydropyrido2,1-bquinazolin-11-one (4aR,8aS)-3-Phenyl-2-thioxo-2,3,4a,5,8,8a-hexahydro-1H-quinazolin-4-one cis-2-(p-clorophenyl)-1,2,4a,5,8,8a-hexahydro-4H-3,1-benzoxazine ((1S,6R)-6-Hydroxymethyl-cyclohex-3-enyl)-carbamic acid ethyl ester

专利信息

专利号:WO-2007091110-A1
优先权日:2006-02-09
标 题 :Enzymatic resolution process for the preparation of cycli-c beta-amino acid and ester enatiomers
发明人：FORRO ENIKO; FUELOEP FERENC
权利人:UNIV SZEGEDI; FORRO ENIKO; FUELOEP FERENC
摘要:The invention relates to a process for the preparation of cyclic β-amino acid and ester enantiomers of general formula (I) wherein R is hydrogen or optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl and heteroaryl, wherein each ring may optionally be condensed; A is alkylene or alkenylene, and one or more carbon atoms of each groups may optionally be replaced with one or more heteroatoms; Rl and R2 are hydrogen or halogen, =(O)n, optionally halogenated alkyl, alkylidene, alkoxy, optionally protected hydroxy, optionally protected amino, mono- or dialkylamino and optionally substituted phenyl, or Rl and R2 taken together with one or any two atoms of the ring to which they are attached, form a saturated, unsaturated or aromatic fused homo- or heterocyclic ring; n is 0, 1 or 2; * denotes a chiral carbon atom; and the salts thereof, comprising the steps of hydrolysing a mixture of cyclic β-amino ester enantiomers with a stereoselective hydrolytic enzyme, and separating the obtained acid enantiomer and the unreacted ester enantiomer. The invention provides an enzymatic resolution procedure for the preparation of enantiomers of both the cis- and trans-cyclic β-amino acids and esters useful for the synthesis ' of biologically active agents.

专利号:EP-2305808-B1
优先权日:2001-06-20
标 题:Templated molecules and methods for using such molecules
发明人：PEDERSEN HENRIK; GOULIAEV ALEX HAAHR; SAMS CHRISTIAN KLARNER; SLØK FRANK ABILGAARD; FRESKGÃ…RD PER-OLA; HOLTMANN ANETTE; OLSEN EVA KAMPMANN; HUSEMOEN GITTE NYSTRUP; FELDING JAKOB; FRANCH THOMAS; THISTED THOMAS; HYLDTOFT LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER
权利人:NUEVOLUTION AS
摘要:The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g . therapeutic activity.

专利号:US-9688980-B2
优先权日:2001-06-20
标 题 :Templated molecules and methods for using such molecules
发明人：PEDERSEN HENRIK; GOULIAEV ALEX HAAHR; FRANCH THOMAS; SAMS CHRISTIAN KLARNER; OLSEN EVA KAMPMANN; SLOK FRANK ABILGAARD; HUSEMOEN GITTE NYSTRUP; FELDING JAKOB; HYLDTOFT LENE; NORREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRODER; THISTED THOMAS; FRESKGARD PER-OLA; HOLTMANN ANETTE
权利人:NUEVOLUTION AS; NUEVOLUTION
摘要:The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.