CAS: 947407-84-3; 4-Bromo-5,6-Dihydropyridin-2(1H)-One

英文名称4-Bromo-5,6-Dihydropyridin-2(1H)-One
中文名称4-溴5,6-二氢吡啶-2(1H)-酮
IUPAC名称4-bromo-5,6-dihydropyridin-2(1H)-one
其它别名2-羟基-4-溴吡啶 1G; 4-Bromopyridin-2(1H)-One
CAS编号947407-84-3
MFCD编号:MFCD15527080
分子式:C5H6BrNO
分子量:176.01
产品CID: 1999660
产品分类有机原料→分子砌块→脂肪杂环类化合物→其它脂肪杂环类化合物

相似结构搜索
InChIKey: MPNYEJLHNYBCFM-UHFFFAOYSA-N
InChI=1S/C5H6BrNO/c6-4-1-2-7-5(8)3-4/h3H,1-2H2,(H,7,8)…
计算化学: 氢键受体数1.0氢键供体数1.0可旋转键数0.0

相似化合物

6052-73-9 1016555-70-6 1823765-82-7

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

上下游产品

4-bromo-1-tert-butyl-5,6-dihydro-1H-pyridin-2-one 1-tert-butyl-piperidine-2,4-dione 4-bromo-1-(3,4-difluorobenzyl)-5,6-dihydropyridine-2(1H)-one

合成工艺路线路线简述

947407-85-4 = 947407-84-3
反应条件:1.1 Solvents: Trifluoroacetic Acid; 3.5 H,Reflux
标题:Preparation And Intramolecular [2+2]-Photocycloaddition Of 1,5-Dihydropyrrol-2-Ones And 5,6-Dihydro-1H-Pyridin-2-Ones With C-,N-,And O-Linked Alkenyl Side Chains At The 4-Position
作者:Albrecht,Dominik; Basler,Birte; Bach,Thorsten
参考文献:Journal Of Organic Chemistry 日期:2008 卷标:73(6) 页码:2345-2356]

947407-85-4 = 947407-84-3
反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane; 30 Min,Rt
标题:Synthesis Of 4-Substituted 1,5-Dihydropyrrol-2-Ones And 5,6-Dihydro-1H-Pyridin-2-Ones By Negishi Cross-Coupling Reactions: Short Access To The Antidepressant (+/-)-Rolipram
作者:Albrecht,Dominik; Bach,Thorsten
参考文献:Synlett 日期:2007 卷标:(10) 页码:1557-1560

1-(叔丁基)哌啶-2,4-二酮置于草酰溴,N,N-二甲基甲酰胺,三氟乙酸体系中,用二氯甲烷作为反应溶剂,化学反应 2.0H,反应生成 4-溴-5,6-二氢吡啶-2(1H)-酮
参考文献:Synthesis Of 4-Substituted 1,5-Dihydropyrrol-2-Ones And 5,6-Dihydro-1H-Pyridin-2-Ones By Negishi Cross-Coupling Reactions: Short Access To The Antidepressant (+/-)-Rolipram
标题:Synthesis Of 4-Substituted 1,5-Dihydropyrrol-2-Ones And 5,6-Dihydro-1H-Pyridin-2-Ones By Negishi Cross-Coupling Reactions: Short Access To The Antidepressant (+/-)-Rolipram
摘要:通过易得的溴化物3和6与各种官能化锌试剂的钯催化的根岸偶联反应,建立了一种合成目标化合物的直接方法(产率71-97%).
DOI:10.1055/s-2007-982553