CAS: 86847-79-2; N-(6-Methylpyridin-2-yl)Pivalamide

该化合物是一种专门的有机化合物,其主干脊柱以pivalolololamino组替代,具有独特的消毒和电子特性,使其作为制药和农用化学合成的中间体具有价值.它的静脉球能增强稳定性,而环则为进一步功能化提供回动性.该化合物因其能够调节溶解性和代谢稳定性,在生物活性分子的开发方面特别有用.高纯度能确保研究和工业应用的一贯性能.其定义明确的化学特性有利于对合成途径的精确控制,支持药用化学和材料科学的进步.

英文名称N-(6-Methylpyridin-2-yl)Pivalamide
中文名称2-特戊酰氨基-6-甲基吡啶
IUPAC名称N-(6-methylpyridin-2-yl)pivalamide
其它别名2 - 新戊酰基氨基-6 - 甲基吡啶; 2-Pivaloylamino-6-Picoline
CAS编号86847-79-2
MFCD编号:MFCD00996301
EINECS号:168-281-3
分子式:C11H16N2O分子量:192.26
产品CID: 1871760
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: MAZMJMLUKYPLEI-UHFFFAOYSA-N
InChI=1S/C11H16N2O/c1-8-6-5-7-9(12-8)13-10(14)11(2,3)4/h5-7H,1-4H3,(H,12,13,14)
计算化学: 氢键受体数2.0氢键供体数1可旋转键数1

相似化合物

86847-59-8 5327-33-3 857292-64-9

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(经口)
严重眼刺激类别2
警示词Warning(警告)
危险描述H302 |吞咽有害.
H319 |造成严重眼刺激.
防范说明P264-P280-P302+P352-P362+P364

欧盟法规

C&L通报

上下游产品

合成工艺路线路线简述

1824-81-3 = 86847-79-2
反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; Cooled; 15 Min,0 °C; Overnight,Rt
标题:Inter- And Intramolecular Hydroacylation Of Alkenes Employing A Bifunctional Catalyst System
作者:Vautravers,Nicolas R.; Et Al
参考文献:Chemical Communications (Cambridge 日期:2011 卷标:47(23) 页码:6635-6637]

1824-81-3 = 86847-79-2
反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; 24 H,20 °C
标题:Optimization Of Permanganate Oxidation And Suzuki-Miyaura Coupling Steps In The Synthesis Of A Nav1.8 Sodium Channel Modulator
作者:Fray,M. Jonathan; Et Al
参考文献:Organic Process Research & Development 日期:2010 卷标:14(1) 页码:263-271]

1824-81-3 = 86847-79-2
反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; 0 °C
标题:A Hydrogen-Bond Facilitated Cycle For Oxygen Reduction By An Acid- And Base-Compatible Iron Platform
作者:Soo,Han Sen; Et Al
参考文献:Inorganic Chemistry 日期:2009 卷标:48(21) 页码:10024-10035

📜三甲基乙酰氯,3-甲基苯胺置于三乙胺体系中,用二氯甲烷作为反应溶剂,化学反应生成 2-特戊酰氨基-6-甲基吡啶
参考文献:Synthesis,Characterisation And Evaluation Of A Novel Copper-64 Complex With Selective Uptake In Emt-6 Cells Under Hypoxic Conditions
标题:Synthesis,Characterisation And Evaluation Of A Novel Copper-64 Complex With Selective Uptake In Emt-6 Cells Under Hypoxic Conditions
摘要:放射性金属 64Cu 目前被广泛用于正电子发射断层扫描(pet)诊断成像剂的开发.本研究开发并评估了一种新型 64Cu 螯合剂:新型单硫脲三元配体 1-苯甲酰基-3-{6-[(双吡啶-2-基甲基氨基)-甲基]-吡啶-2-基}-硫脲(mtubo).x 射线晶体学分析表明,这种配体与铜(II)形成单核配合物,并通过供体原子的三叉双锥 N4S 阵列配位.令人欣慰的是,细胞吸收研究表明,64Cu-Mtubo 可选择性地在缺氧条件下培养的 Emt-6 细胞中积累,这可能是由于它具有相对较高的 Cuii/i 氧化还原电位.在携带 Emt-6 肿瘤的 Balb/c 小鼠体内进行的小动物 Pet 成像和体内外生物分布研究显示,肿瘤在注射 1 小时后显著吸收,肿瘤与肌肉(t/m)和肿瘤与血液(t/b)的比率分别为 8.1 和 1.1.然而,注射醋酸 64Cu 会产生类似的摄取,这表明所观测到的摄取很可能是非特异性的.尽管该复合物在体外显示出很高的稳定性,但在体内,它很可能在相对较短的时间内与血液中的蛋白质发生转切作用.作为比较,缺氧成像剂 64Cu-Atsm 也在相同的小鼠肿瘤模型中进行了评估,其肿瘤摄取量比 64Cu-Mtubo 高出约 60%.
DOI:10.1039/c3Dt50960E

海关参考信息

2912110000-甲醛
2912120000-乙醛
2933310010-吡啶
2924199090-其他无环酰胺
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:WO-2025128848-A1
优先权日:2023-12-12
标题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

专利号:WO-2025128873-A1
优先权日:2023-12-12
标题:Heterocyclic pyridinone compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).