CAS: 80041-89-0; Isopropylboronic Acid

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Potassium Isopropyltrifluoroborate置于水体系中,用 四氢呋喃 作为反应溶剂,化学反应生成 异丙基硼酸
参考文献:有机三氟硼酸盐水解:硼酸释放机制和交叉偶联中的酸碱悖论
标题:有机三氟硼酸盐水解:硼酸释放机制和交叉偶联中的酸碱悖论
摘要:有机三氟硼酸钾 (Rbf(3)K) 试剂水解为相应的硼酸 (Rb(Oh)(2)) 已经在它们在铃木宫浦耦合中的应用的上下文中进行了研究.只有当 Rbf(3)K 试剂的水解速率与催化转化率有适当的配合时,这种 Sm 耦合中的"缓慢释放"策略才可行.在这种情况下,硼酸 Rb(Oh)(2) 基本上不会积累,从而最大限度地减少副反应,例如氧化均偶联和原脱硼.研究表明,水解速率(thf,H(2)O,Cs(2)Co(3),55 oc)取决于许多变量,导致一些 Rbf(3)K 试剂产生复杂的溶剂分解曲线.例如,那些基于 Pf-苯基,萘基,呋喃基,发现苄基部分需要酸催化才能有效水解.这种酸碱悖论确保了它们在碱性 Suzuki-Miyaura 偶联条件下缓慢水解.然而,由 Cs(2)Co(3) 引起的 Thf/h(2)O 的部分相分裂,导致本体介质中的 Ph 值较低,导致反应容器的形状,材料,尺寸和搅拌速率
DOI:10.1021/ja300236K

专利信息

专利号:US-5736535-A
优先权日:1992-04-16
标 题:1-pyrimidinylacetamide compounds which are inhibitors of human leukocyte elastase
发明人：BERNSTEIN PETER ROBERT; EDWARDS PHILIP DUKE; SHAW ANDREW; SHENVI ASHOKKUMAR BHIKKAPPA; THOMAS ROYSTON MARTIN; VEALE CHRIS ALLAN; WARNER PETER; WOLANIN DONALD JOHN
权利人:ZENECA LTD
摘要:The present invention relates to certain novel substituted derivatives which are 1-pyrimidinylacetamide derivatives of formula I, ##STR1## which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these substituted derivatives, processes for preparing the substituted derivatives, pharmaceutical compositions containing such substituted derivatives and methods for their use.

专利号:US-8207337-B2
优先权日:2007-01-29
标 题:Reagent for organic synthesis reaction containing organic triol borate salt
发明人：MIYAURA NORIO; YAMAMOTO YASUNORI
权利人:MIYAURA NORIO; YAMAMOTO YASUNORI; WAKO PURE CHEM IND LTD
摘要:[Problem] n To provide an organoboron compound-containing reagent for organic synthesis reactions which undergoes no trimerization with dehydration, does not necessitate activation with a base, and is stable and highly active. n [Means for Solving Problems] n The reagent for organic synthesis reactions contains an organic triol borate salt represented by any of the general formulae (I) to (III) and general formula (XVI): (wherein R 1 represents alkyl, alkenyl, etc.; R 2 represents optionally substituted alkyl, alkenyl, alkynyl, etc. or represents hydrogen; m + represents an alkaline metal ion, phosphonium ion, or given ammonium ion; M 2+ represents an alkaline earth metal; X represents halogen or alkoxide; Y represents an alkali metal ion, etc.; A represents optionally substituted methylene; and n represents an integer).

专利号:US-8022235-B2
优先权日:2007-06-01
标 题 :Compositions of phospholipid ether boronic acids and esters and methods for their synthesis and use
发明人：PINCHUK ANATOLY; WEICHERT JAMEY P; LONGINO MARC
权利人:CELLECTAR INC
摘要:The present invention discloses boronic acids and esters of phospholipid ether analogs and methods for their synthesis and use. The boronic acids and esters of phospholipid ether analogs described herein can be used in treating cancer and in particular can be used in conjunction with radiation therapy, such as external beam radiation therapy and neutron capture therapy to specifically target and kill cancer cells.

专利号:WO-9321213-A1
优先权日:1992-04-16
标题 :Alpha-aminoboronic acid peptides and their use as elastase inhibitors
发明人：BERNSTEIN PETER ROBERT; SHAW ANDREW; SHENVI ASHOKKUMAR BHIKKAPPA; THOMAS ROYSTON MARTIN; WARNER PETER; WOLANIN DONALD JOHN
权利人:ZENECA LTD
摘要:The present invention relates to certain novel heterocyclic derivatives which are 1-pyridylacetamide derivatives of formula (I), set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases on mammals in which (HLE) is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic derivatives, processes for preparing the heterocyclic derivatives, pharmaceutical compositions containing such heterocyclic derivatives and methods for their use.

专利号:US-2009018357-A1
优先权日:2007-06-01
标题:Compositions of phospholipid ether boronic acids and esters and methods for their synthesis and use

专利号:US-11794180-B2
优先权日:2015-10-29
标 题 :Tri-(adamantyl)phosphines and applications thereof
发明人：CARROW BRAD P; CHEN LIYE
权利人:UNIV PRINCETON
摘要:In one aspect, phosphine compounds comprising three adamantyl moieties (PAd3) and associated synthetic routes are described herein. Each adamantyl moiety may be the same or different. For example, each adamantyl moiety (Ad) attached to the phosphorus atom can be independently selected from the group consisting of adamantane, diamantane, triamantane and derivatives thereof. Transition metal complexes comprising PAd3 ligands are also provided for catalytic synthesis including catalytic cross-coupling reactions.