CAS: 75-61-6; Dibromo(Difluoro)Methane

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ECHA物质ECHA物质C&L通报REACH预注册

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Difluoromethane halon-1211 tribromofluoromethane carbon tetrabromide1-bromo-1,1-difluoro-but-2-ene 1,3-dibromo-1,1-difluoro-butane 1,1-difluoro-1,3-dibromopropane 1,3-dibromo-1,1,3-trifluoro-propane

合成工艺路线路线简述

    二氯四氟丙酮置于溴体系中,化学反应生成 二溴二氟甲烷
    参考文献:Manufacture Of Fluorohalomethanes
    标题:Manufacture Of Fluorohalomethanes

    海关参考信息

    专利信息


    专利号:US-4756739-A
    优先权日:1985-12-21
    标题 :Pyridine derivatives and the N-oxides thereof, and the use thereof as intermediates for the synthesis of plant protecting agents
    发明人:FUSS ANDREAS; KOCH VOLKER
    权利人:HOECHST AG
    摘要:The compounds of the formula I (I) in which A denotes N or N->O, Z denotes O or NH, R denotes H, (halo)alkyl, (halo)alkenyl, (halo)alkynyl or alkoxycarbonyl, R1 denotes hydrogen, halogen, amino, -NHOH, hydroxyl, (substituted) phenylazo or a radical of the formulae Y=C=N-, Y1Y2C=N-, Y3NH- or K denotes 0 or 1, and m and n, independently of one another, denote a number from 1 to 4, with the proviso that, when Z-R denotes OH or NH2, (R1)n denotes at least one radical of the formula or represents two radicals, in the 5 or 6 position of the heterocyclic ring, which, in the 5 position, denote halogen and, in the 6 position, denote a radical of the group comprising halogen, amino, hydroxyl or phenylazo, which may be substituted as specified above, are valuable intermediates in the synthesis of plant protection agents.

    专利号:US-4749802-A
    优先权日:1984-09-17
    标题:Method of preparation of trifluoromethyl copper and trifluoromethyl aromatics
    发明人:BURTON DONALD J; WIEMERS DENISE M; EASDON JEROME C
    权利人:UNIV IOWA RES FOUND
    摘要:The process of direct synthesis of trifluoromethyl copper and trifluoromethyl aromatics, both intermediate reagents useful in direct synthesis of certain perfluoroalkyl compounds. The process involves a direct reaction between on the one hand an aromatic halide and a difluorodihalomethane and on the other hand copper and a difluorodihalomethane.

    专利号:US-4895991-A
    优先权日:1984-09-17
    标题 :Method of preparation of trifluoromethyl copper and trifluoromethyl aromatics
    发明人:BURTON DONALD J; WIEMERS DENISE M; EASDON JEROME C
    权利人:UNIV IOWA RES FOUND
    摘要:The process of direct synthesis of trifluoromethyl copper and trifluoromethyl aromatics, both intermediate reagents useful in direct synthesis of certain perfluoroalkyl compounds. The process involves a direct reaction between on the one hand an aromatic halide and a difluorodihalomethane and on the other hand copper and a difluorodihalomethane.

    专利号:US-12319691-B2
    优先权日:2020-05-04
    标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
    发明人:CZABANIUK LARA C; HOPPER TIMOTHY; HOUZE JONATHAN B; RESCOURIO GWENAELLA; SANTORA VINCENT; WANG HAOXUAN; WHITE RYAN D; WONG ALICE R; WU YONGWEI
    权利人:AMGEN INC; VIGIL NEUROSCIENCE INC
    摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

    专利号:US-6271392-B1
    优先权日:1994-10-07
    标题:Intermediates useful for the synthesis of 1-arylpyrrole pesticides
    发明人:CHENE ALAIN; HUBER SCOT KEVIN
    权利人:RHONE POULENC INC
    摘要:The present invention pertains to novel 3-substituted-4-thiopyrrole intermediates for the preparation of 1-arylpyrrole compounds that are useful for the control of insects, acarids and nematodes. n The compounds, including their isomers, e.g., diastereomers and optical isomers, are compounds of a general formula (I) n wherein the structural variables are as defined in the description.

    专利号:US-7119232-B2
    优先权日:2004-03-26
    标题 :Nucleophilic substitution reactions of difluorormethyl phenyl sulfone with alkyl halides leading to the facile synthesis of terminal 1,1-difluoro-1-alkenes and difluoromethylalkanes
    发明人:PRAKASH G K SURYA; HU JINBO; OLAH GEORGE A; WANG YING
    权利人:UNIV SOUTHERN CALIFORNIA
    摘要:(Benzenesulfonyl)difluoromethyl anion, in situ generated from difluoromethyl phenyl sulfone and a base, was found to easily undergo nucleophilic substitution reactions (S N 2) with primary alkyl halides, elemental halogens, and perfluoroalkyl halides with good selectivity. The formed (benzenesufonyl)difluoromethylalkanes are useful intermediates for the facile preparation of 1,1-difluoro-1-alkenes and difluoromethylalkanes. Thus, difluoromethyl phenyl sulfone acts as both “CF 2 â•?â€? and “CF 2 H − â€? synthons
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    合成参考文献


    摘要:Koo, S., Science of Synthesis, (2010) 45, 1376.
    摘要:Grainger, R. S.; Jervis, P. J., Science of Synthesis, (2009) 46, 427.
    摘要:Hou, X.-L.; Peng, X.-S.; Yeung, K.-S.; Wong, H. N. C., Science of Synthesis Knowledge Updates, (2011) 2, 362.
    摘要:Kantlehner, W., Science of Synthesis Knowledge Updates, (2014) 4, 380.
    摘要:Kantlehner, W., Science of Synthesis Knowledge Updates, (2014) 4, 365.
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