CAS: 74-61-3; 2,3-Disulfanylpropane-1-Sulfonic Acid

上下游产品

sodium thioacetate unithiol

📜Pb{pb(C3H5O3S3)}2置于盐酸,碳酸氢钠体系中,用 甲醇 作为反应溶剂,化学反应 2.0H,以70.3%的收率获得产物二巯基丙磺酸钠
参考文献:一种改进的2,3-二巯基丙磺酸钠的合成方法
标题:一种改进的2,3-二巯基丙磺酸钠的合成方法
摘要:本发明属于有机或药物合成领域,涉及一种改进的2,3‑二巯基丙磺酸钠的合成方法.本发明的技术解决方案为:巯基化反应,硫氢化钠(钾)溶液ph值是巯基化反应的重要工艺参数,本发明是用市售nahs固体用水溶解,用浓盐酸等卤代酸中和至ph=6.5~7,再和二溴丙磺酸钠反应,同样为2,3‑二巯基丙磺酸钠的巯基化反应提供了高选择性的环境和条件,避免使用到剧毒气体硫化氢,改善工况条件.同时脱铅反应用氯化氢甲醇溶液,避免使用对环境有影响的剧毒气体硫化氢,改善工况条件.

专利信息

专利号:US-8404804-B2
优先权日:2007-08-28
标 题 :Methods and intermediates for chemical synthesis of polypeptides and proteins
发明人：DONG ZHENG XIN; EYNON JOHN S
权利人:DONG ZHENG XIN; EYNON JOHN S; IPSEN PHARMA SAS
摘要:The present invention relates to methods and intermediates for chemical synthesis of polypeptides and proteins, and more particularly to methods and intermediates for chemically ligating a peptide fragment containing N-terminal N-methyl-cysteine (SEQ ID NO: 1) with another peptide fragment having C-terminal thioester to generate a β-(methylamino)-thioester intermediate that spontaneously rearranges to form an amide bond. Furthermore, the invention relates to methods of converting N-methyl-thiazolidine to N-methyl-cysteine (SEQ ID NO: 1) of polypeptides and proteins. The invention also relates to methods of synthesizing peptide-thioester from peptide-acid fluoride.

专利号:US-2010204449-A1
优先权日:2007-09-04
标 题 :Methods and intermediates for chemical synthesis of polypeptides and proteins
发明人：DONG ZHENG XIN; KIM SUN H
权利人:DONG ZHENG XIN; KIM SUN H
摘要:The present invention relates to methods and intermediates for chemical synthesis of polypeptides and proteins, and more particularly to methods and intermediates for chemically ligating a peptide fragment containing N-terminal β-methyl-cysteine (SEQ ID NO: 1) with another peptide fragment having C-terminal thioester to generate a β-amino-thioester intermediate that spontaneously rearranges to form an amide bond. The invention also relates to methods of synthesizing β-methyl-cysteine (SEQ ID NO: 1) and its protected forms. Furthermore, the invention relates to converting a β-methyl-thiazolidine residue to a β-methyl-cysteine (SEQ ID NO: 1) residue of polypeptides and proteins.

专利号:US-2025154546-A1
优先权日:2022-02-11
标题 :Use of 3'-oxymethylene alkyl disulfide protected nucleotides for enzymatic dna and rna synthesis
发明人：MARMA SANO MONG; SOLIMAN SAMEH; GUAN XIAO-PEI; PERBOST MICHEL; PINARD ROBERT
权利人:MILTENYI BIOTEC BV & CO KG
摘要:This invention is about enzymatic synthesis of nucleic acids using 3′-O—(CH2SSR) protected reversible nucleotide terminators. The nucleotide base of the protected nucleotide may consist of natural or non-natural (e.g. 7-de-aza G and 7-de-aza A), or mixture thereof. The base of the nucleotides can be modified with a linker carrying carboxylic acid (—CO2H). amine (—NH2), thiol (—SH). hydroxymethyl (—CH2OH), propargy lamine. alkyne group etc. for subsequent modification and labeling. Such nucleotide substrates can be incorporated into the single strand, template free nucleic acid or into the templated DNA hybrid. And in later step the 3′-O—CH2SSR protecting group can be cleaved off by chemical treatment pre-requisites for enzymatic nucleic acids synthesis. By adding nucleotide in pre-determined fashion and cleave reaction after each step. longer DNA strands can be synthesized in solution or on solid surface starting from a short seeding DNA strands.

专利号:US-8138272-B2
优先权日:2006-05-22
标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
发明人：KONRADI ANDREI W; SMITH JENIFER L
权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.

专利号:US-2016293932-A1
优先权日:2015-03-30
标题 :Synthetic methods for transition metal coordination compounds
发明人：MOTALLEBI SHAHROKH; RISSET OLIVIA NATHALIE; WESSELLS COLIN DEANE
权利人:ALVEO ENERGY INC
摘要:A system and method for controlling particle morphology of transition metal coordination compounds (TMCC). Synthesis of TMCC using one of several chelating agents having carboxylate chemical groups. These carboxylate groups bind to copper during the synthesis of the CuHCF TMCC materials, resulting in controlled particle growth, rather than rapid formation of many small nanoparticles as is the case without any chelating agent present. The materials produced using chelating agents of these embodiments such as these are composed of larger particles, making them easier to process into battery electrodes via standard methods such as slurry mixing and coating. The resulting electrodes retain the good electrochemical cycling performance of the control material synthesized without a chelating agent.

专利号:US-6476086-B1
优先权日:2001-04-04
标题:Coalescence enhanced gravity separation of iron catalyst from Fischer-Tropsch catalyst/wax slurry
发明人：ZHOU PEIZHENG
权利人:HYDROCARBON TECHNOLOGIES INC
摘要:Fine iron-based catalyst particles from. Fischer-Tropsch (F-T) synthesis processes are effectively separated from catalyst/liquid/wax slurry by contacting and/or mixing the slurry with a coalescence enhancing treating solution to facilitate gravity separation and settling of such catalyst, and thereby yield a substantially clean hydrocarbon liquid/wax product. The treating solution includes a surface tension reducing agent, an agglutinating agent, and a coalescing agent each in selected proportions in aqueous solution. Useful mixing and settling conditions are 10-250° C. temperature, 0-500 psig pressure and treating solution to slurry volume ratio of 0.5-5:1, with the settling time for at least about 90% and preferably substantially all of the catalyst fines after the mixing step being less than about 15 minutes. The treating solution can be desirably recovered and reused in the F-T synthesis process, and the recovered catalyst either recycled or disposed as desired.