专利号:US-9481678-B2 优先权日:2015-02-09 标题 :Substituted pyrrolo[2,3-D]dipyrimidines for selectively targeting tumor cells with FR-alpha and FR-beta type receptors 发明人:GANGJEE ALEEM; MATHERLY LARRY H 权利人:DUQUESNE UNIV OF THE HOLY GHOST; UNIV WAYNE STATE 摘要:Pyrrolo[2,3-d]pyrimidine derivatives, and pharmaceutical acceptable salts thereof, useful in therapeutically treating patients with cancer are disclosed. These compounds selectively target folate receptors (FR) of cancerous tumor cells and inhibit purine synthesis and hence, DNA synthesis.
专利号:US-9611281-B2 优先权日:2013-12-05 标题:BODIPY derivatives and methods of synthesis and use thereof 发明人:YOU YOUNGJAE; AWUAH SAMUEL; WATLEY RYAN 权利人:UNIV OKLAHOMA 摘要:Derivatives of BODIPY (boron dipyrromethene difluoride) and their synthesis and use are disclosed.
专利号:US-10647688-B2 优先权日:2014-12-19 标题:Compounds, synthesis method thereof and use of same in medicine and in cosmetics 发明人:PORTAL THIBAUD 权利人:GALDERMA RES & DEV 摘要:Novel compounds, synthesis methods and use of the same in medicine and in cosmetics are disclosed. Also disclosed, are novel compounds and ligands that modulate RARs.
专利号:US-4374770-A 优先权日:1981-10-08 标题:Process for preparation of aromatic acid chlorides 发明人:HYATT JOHN A; KASHDAN DAVID S 权利人:EASTMAN KODAK CO 摘要:Disclosed is a process for converting aromatic aldehydes to the corresponding acid chlorides by reacting an aromatic aldehyde with sulfuryl chloride in the presence of a catalytic amount of a phosphine, phosphine oxide or phosphonium compound. The product compounds produced by the process of this invention are useful as chemical synthesis intermediates in the preparation of pharmaceuticals, dyes, herbicides and photographic chemicals.
专利号:WO-9948868-A9 优先权日:1998-03-26 标 题 :Heterocyclic classes of compounds for the modulating tyrosine protein kinase 发明人:FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL 权利人:SUGEN INC; UNIV NEW YORK; MAX PLANCK INST FUR BIOCHEMIE; FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL 摘要:The invention relates to certain indolinone-based and pyrazolylamide-based compounds, their method of synthesis, and combinatorial libraries consisting of the compounds. The invention also relates to methods of modulating the function of protein kinases using these compounds and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.
专利号:EP-2084147-B1 优先权日:2006-08-29 标 题:Heterocyclic fxr binding compounds 发明人:KREMOSER CLAUS; DEUSCHLE ULRICH; ABEL ULRICH; SCHULZ ANDREAS 权利人:PHENEX PHARMACEUTICALS AG 摘要:The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists or partial agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.
摘要:Snaith, J. S., Science of Synthesis Knowledge Updates, (2011) 2, 234. 摘要:Sellars, J. D., Science of Synthesis Knowledge Updates, (2014) 1, 398. 摘要:Zhang, M.; Su, W., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 104. 摘要:Lastovickova, D. N.; Teator, A. J.; Bielawski, C. W., Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (2016) 1, 442.