CAS: 63547-13-7; Adrafinil

上下游产品

2-benzhydrylsulfanyl-N-hydroxyacetamide 1,1-Diphenylmethanol (benzhydrylthio)acetic acid (diphenylmethyl)(ethyl acetate)sulfide

📜2-Benzhydrylsulfanyl-N-Hydroxyacetamide置于双氧水,溶剂黄146体系中,用72%的收率获得产物艾捉非尼
参考文献:Synthesis And Determination Of The Absolute Configuration Of The Enantiomers Of Modafinil
标题:Synthesis And Determination Of The Absolute Configuration Of The Enantiomers Of Modafinil
摘要:The Asymmetric Synthesis Of Both Enantiomers Of Modafinil,A Unique Cns Stimulant With A Reduced Abuse Liability,Is Described. This Approach Effectively Prepares Modafinil On A Multigram Scale In Several Steps From Benzhydrol. The Described Synthetic Route Has Also Been Used To Produce The More Water Soluble Analogue,Adrafinil. X-Ray Crystallographic Analysis On (Diphenylmethanesulfinyl)Acetic Acid Has Determined The Absolute Configuration To Be R. (C) 2004 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tetasy.2004.01.039

专利信息

专利号:US-7553646-B2
优先权日:2005-07-28
标题 :Microbial sulfoxidation and amidation of benzhdrylsulfanyl carboxylic acids and uses thereof
发明人：OLIVO HORACIO F; OSORIO-LOZADA ANTONIO VICTOR
权利人:UNIV IOWA RES FOUND
摘要:The present invention provides novel methods for the synthesis of racemic and enantiomers of modafinil via microbial oxidation-amidation transformation. The methods include the successive oxidation-amidation of benzhydrylsulfanyl carboxylic acid to produce racemic and enantiomers of modafinil using at least one microorganism of yeast, bacteria, or fungus. Also disclosed are pharmaceutical compositions of racemic and enantiomers of modafinil along with their use in the treatment of diseases, including attention deficit hyperactivity disorder and drug addiction.

专利号:US-2008214827-A1
优先权日:2004-02-03
标 题:Synthesis of Cyanoimino-Benzoimidazoles
发明人：GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
权利人:EURO CELTIQUE SA
摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.

专利号:US-7749985-B2
优先权日:2006-09-15
标 题 :Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
发明人：GALLOP MARK A; XU FENG; PHAN THU; DILIP USHA; PENG GE
权利人:XENOPORT INC
摘要:Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs 3-aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.

专利号:CA-2555219-A1
优先权日:2004-02-03
标 题 :Synthesis of cyanoimino-benzoimidazoles

专利号:US-9751877-B2
优先权日:2012-09-21
标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-2024342119-A1
优先权日:2021-08-02
标 题:Composition for treating hypertrophic scars and keloids comprising benzhydryl thioacetamide compound as active ingredient
发明人：KIM SEONG-JIN; KIM SEON-MYUNG
权利人:CELLIONBIOMED INC
摘要:The present invention relates to a composition for treating hypertrophic scars and keloids, comprising a benzhydryl thioacetamide compound as an active ingredient. The benzhydryl thioacetamide compound inhibits cell proliferation and an increase in intracellular Ca 2+ concentration, in fibroblasts, keratinocytes and vascular endothelial cells that are involved in skin fibrosis, and inhibits the synthesis of collagen, which is the extracellular matrix, and thus has the effect of effectively treating intractable hypertrophic scars and keloids.