CAS: 5551-12-2; 4-Bromo-2-Nitrobenzaldehyde

该化合物是一种有机化合物,其特点是芳香结构,包括溴原子和一种与苯并二丁二烯协会相连的硝基集团,其分子式为C7H4BRN2O3,表明存在7个碳原子,4个氢原子,1个溴原子,2个氮原子和3个氧原子.该化合物一般是黄色至橙色晶状固体,由于存在电离硝基和甲酰二苯功能组,其反应性也为人所知.它经常用于有机合成,特别是用于制作各种药品和农用化学品.该复合物在有机溶剂中表现出中等溶性,在水中溶性较小.其特性包括一种独特的芳香味和潜在毒性,在实验室环境中需要小心处理.与许多卤化化合物一样,它也可能造成环境关切,突出适当处置和管理做法的重要性.

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上下游产品

CAS号22996-19-6 4-溴-2-硝基苄醇 | CAS号135308-80-4 4-bromo-2-nitro... | CAS号3460-18-2 2,5-二溴硝基苯 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号552-89-6 邻硝基苯甲醛 | CAS号82420-34-6 4-溴-2-硝基苄基溴 | CAS号408526-96-5 4-bromo-2-nitro... | CAS号106-49-0 对甲苯胺 | CAS号953039-65-1 7-溴喹唑啉-2(1H)-酮 | CAS号29124-57-0 2-氨基-5-溴苯甲醛 | CAS号99277-71-1 2-硝基-4-溴苯甲酸 | CAS号953039-66-2 7-溴-2-氯喹唑啉 | CAS号59278-65-8 2-氨基-4-溴苯甲醛

合成工艺路线路线简述

  • 合成目标产物 4-Bromo-2-Nitrobenzaldehyde 主要起始原料 4-Bromo-2-Nitrobenzyl Alcohol
  • (文献来源)合成步骤主要原料 4-Bromo-2-Nitrobenzyl Alcohol
📜4-溴-2-硝基苄基溴置于碳酸氢钠,二甲基亚砜体系中,化学反应 12.0H,以68%的收率获得产物4-溴-2-硝基苯甲醛
参考文献:Jung,Michael E.; Dansereau,Susan M.K.,Heterocycles,1994,Vol. 39,# 2,P. 767-778
标题:Jung,Michael E.; Dansereau,Susan M.K.,Heterocycles,1994,Vol. 39,# 2,P. 767-778

海关参考信息

专利信息


专利号:US-8314090-B2
优先权日:2008-11-06
标 题:Methods of synthesis of benzazepine derivatives
发明人：HOWBERT J JEFFRY; KUSUKUNTLA VENKAT REDDY; TRETYAKOV ALEXANDER; NIELSEN NATHAN; KRASIK PAVEL; JIANG JI-LONG; YANG HONG WOON
权利人:HOWBERT J JEFFRY; KUSUKUNTLA VENKAT REDDY; TRETYAKOV ALEXANDER; NIELSEN NATHAN; KRASIK PAVEL; JIANG JI-LONG; YANG HONG WOON; VENTIRX PHARMACEUTICALS INC; ARRAY BIOPHARMA INC
摘要:The disclosure describes method of synthesis of substituted benzazepine derivatives. Preferred methods according to the disclosure allow for large-scale preparation of benzazepine compounds having low levels of metal impurities. In some embodiments, preferred methods according to the disclosure also allow for the preparation of benzazepine derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. The methods disclosed herein find utility in synthetic organic chemistry as well as medicinal chemistry.

专利号:ES-2705101-T3
优先权日:2008-11-06
标 题:Methods of synthesis of benzazepine derivatives

专利号:CA-2742863-C
优先权日:2008-11-06
标题 :Methods of synthesis of benzazepine derivatives

专利号:AU-2009313392-B2
优先权日:2008-11-06
标题 :Methods of synthesis of benzazepine derivatives

专利号:EP-2358683-A1
优先权日:2008-11-06
标 题 :Methods of synthesis of benzazepine derivatives

专利号:AU-2009313392-A1
优先权日:2008-11-06
标题:Methods of synthesis of benzazepine derivatives

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合成参考文献


参考文献:10.1007/978-3-642-54461-3_2
摘要:Schaefer B. Colourants. 2014. In: Natural Products in the Chemical Industry.
参考文献:10.1055/s-0034-1378672
摘要:Knochel P, Dagousset G, François C, Leόn T, Blanc R, Sansiaume-Dagousset E. Preparation of Functionalized Lithium, Magnesium, Aluminum, Zinc, Manganese, and Indium Organometallics from Functionalized Organic Halides. Synthesis. 2014 Oct 30;46(23):3133–71. doi: 10.1055/s-0034-1378672.
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