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专利信息

专利号:WO-2025027521-A1
优先权日:2023-08-01
标题 :An improved process for the preparation of avibactam and intermediate thereof
发明人：DHAVARIA SANDEEP; HANDA VISHAL; SHARMA SUNEEL KUMAR; MEHTA ANSHU KUMAR; SINGH ADITYA NARAYAN; ABUL AZIM; GUPTA NITIN; SINGH GOVIND; CABRI WALTER
权利人:FRESENIUS KABI ONCOLOGY LTD
摘要:The present invention relates to an improved process for the preparation of Avibactam or a pharmaceutically acceptable salt thereof, particularly the present invention relates to process for the preparation of a bridged ester intermediate of Formula I, wherein R1 is a hydroxy protecting group which is a key intermediate for Avibactam or a pharmaceutically acceptable salt thereof. The present invention also relates to the crystalline form of intermediates used for the synthesis of Avibactam or a pharmaceutically acceptable salt thereof. The invention also provides improved processes for the preparation of Avibactam or a pharmaceutically acceptable salt, using the bridged ester compound of formula I prepared by the process of the present invention.

专利号:US-4337336-A
优先权日:1980-02-25
标 题:Derivative of kanamycin A and a process for the preparation thereof
发明人：UMEZAWA HAMAO; UMEZAWA SUMIO; FUKATSU SHUNZO; YONETA TOSHIO; WAKAZAWA TADASHI
权利人:MICROBIAL CHEM RES FOUND
摘要:There are provided new compounds, 3',4'-anhydro-4'-epi derivatives of kanamycin A of the formula: ##STR1## wherein R represents an alkyl, aralkyl or aryl group and Y represents an alkylidene, aralkylidene, cycloalkylidene or tetrahydropyranylidene group which are useful as an intermediate for the synthesis of 3',4'-dideoxykanamycin A and 4'-deoxykanamycin A from kanamycin A. The compounds of formula (I) can be prepared by treating the corresponding 4'-O-sulfonyl derivative with an alkali metal alcoholate in a lower alkanol under an alkaline condition.

专利号:US-12122769-B2
优先权日:2017-10-19
标题 :Synthesis of antibacterial aminoglycoside analogs
发明人：TREND RAISSA; DAPPEN MICHAEL; HENRY CHRISTOPHER E; GOLDBLUM ADAM AARON; AGGEN JAMES BRADLEY; MENDONÇA RICARDO FILIPE DE JESUS GONÇALVES; SARDINHA JOÃO CARLOS FALCÃO
权利人:CIPLA USA INC
摘要:The present disclosure relates to novel methods for preparing antibacterial aminoglycoside compounds, as well as to related intermediates, and crystal forms thereof, useful in such methods.

专利号:AU-2022253019-A1
优先权日:2021-04-09
标题:Synthesis of rapamycin analog compounds

专利号:EP-3697797-A1
优先权日:2017-10-19
标题 :Synthesis of antibacterial aminoglycoside analogs

专利号:CN-111655709-A
优先权日:2017-10-19
标 题:Synthesis of Antibacterial Aminoglycoside Analogs