CAS: 41372-10-5; Tripiperazine Bis(2-Hydroxypropane-1,2,3-Tricarboxylate) Pentahydrate

专利信息

专利号:US-11512303-B2
优先权日:2017-05-27
标 题 :Engineered polypeptides and their applications in the synthesis of beta-hydroxy-alpha-amino acids
发明人：CHEN HAIBIN; BONG YONG KOY; XU QING; ZHOU AMENG; SHEN TIANRAN; YANG JIADONG; YANG ZHUHONG
权利人:ENZYMASTER NINGBO BIO ENG CO LTD
摘要:The present invention provides engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. The engineered polypeptides disclosed in this invention were developed through directed evolution based on the ability of catalytic synthesis of (2S, 3R)-2-amino-3-hydroxy-3-(4-nitrophenyl) propanoic acid. The present disclosure also provides polynucleotides encoding engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing β-hydroxy-α-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides of the present invention for the preparation of β-hydroxy-α-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption. So, it has good industrial application prospects.

专利号:US-2021284987-A1
优先权日:2017-05-27
标 题:Engineered polypeptides and their applications in the synthesis of beta-hydroxy-alpha-amino acids

专利号:CN-110869383-B
优先权日:2017-05-27
标题:Engineered polypeptides and their application in the synthesis of β-hydroxy-α-amino acids

专利号:CN-110869383-A
优先权日:2017-05-27
标 题 :Engineered Polypeptides and Their Application in Synthesis of β-Hydroxy-α-Amino Acids

专利号:US-11932886-B2
优先权日:2017-12-26
标题:Engineered transaminase polypeptides and uses thereof
发明人：CHEN HAIBIN; BONG YONG KOY; WANG JUANJUAN; CAI BAOQIN; SHANG CHUANYANG; BOCOLA MARCO
权利人:ENZYMASTER NINGBO BIO ENG CO LTD
摘要:Provided are amino acid sequences of engineered transaminase polynucleotide that are useful for asymmetrically synthesizing chiral amine compounds, and its preparation process and reaction process under industrial-relevant conditions. Also provided are polynucleotide sequences encoding engineered transaminase polypeptides, engineered host cells capable of expressing engineered transaminase polypeptides, and methods of producing chiral amine compounds using engineered transaminase polypeptides. Compared to other enzymes, the engineered transaminase polypeptides provided by this invention have better catalytic activity and stability, and are not inhibited by chiral amine products in the synthesis process. The use of the engineered polypeptides of the present invention for the preparation of chiral amine compound results in higher unit activity, and has good industrial application prospects.