CAS: 41059-79-4; Timosaponin A-Iii
该化合物是主要来自阿内玛赫赫纳树种植物的沙邦素化合物,以其在东亚草药中的传统医药用途而闻名;该化合物的特点是复杂的甘醇结构,通常包括一种与糖糖糖相连的类固醇甘油;Timosaponin A III 展示了各种生物活动,包括抗炎,抗氧化剂和潜在的抗癌特性,使其成为药物学研究的课题;其行动机制往往涉及细胞信号路径的调节,有助于其治疗效果;此外,Timosaponin A III 等沙邦因具有形成溶液小鼠的能力,可以提高其他化合物的溶性与生物利用率;然而,Timosaponin A III 的具体药理学和毒性简介需要进一步研究,以充分了解其在医学中的潜在应用.
- 英文名称Timosaponin A-Iii
- 中文名称知母皂苷A3
- IUPAC名称[(25S)-5ß-Spirostan-3ß-yl]2-O-(ß-D-glucopyranosyl)-ß-D-galactopyranoside
- 其它别名TimosaponinA III (7CI); Anemarsaponin A 3; Filiferin B; Sarsasapogenin, 2-O-b-D-glucopyranosyl-b-D-galactopyranoside; Timosaponine A III; Xilingsaponin A; Zhi-mu saponin
- CAS编号41059-79-4
- MFCD编号:MFCD01631164
- EINECS号:683-217-9
- 分子式:C39H64O13分子量:740.92
- 产品CID: 1424974
- 产品分类生物化工 → 提取物
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
CAS号107800-07-7 sarsasapogenyl ...合成工艺路线路线简述
📜Sarsasapogenyl 2,3,4,6-Tetra-O-Acetyl-β-D-Glucopyranosyl-(1->2)-3,4,6-Tri-O-Acetyl-β-D-Galactopyranoside置于氢氧化钾体系中,用 乙醇 作为反应溶剂,化学反应生成 知母皂苷a3
参考文献:通过伪皂苷衍生物环化获得的螺果醇和螺固醇糖苷的抗血小板凝集活性比较.
标题:通过伪皂苷衍生物环化获得的螺果醇和螺固醇糖苷的抗血小板凝集活性比较.
摘要:天然皂苷3和4具有正常的f型环和alpha排列的ch(3)-21基团.用醇性koh处理分别衍生自3和4的假皂苷过乙酸盐18和19,然后用乙酸酸化,得到具有异型f环的螺固醇20和22作为主要产物.通过比较它们的1H-NMR光谱数据和3-Op-溴苯甲酰基sarsasapogenin 7,3-O-乙酰基薯os皂苷元的x射线分析数据,对衍生自假衍生物11,12,18和19的皂甙元和皂苷进行结构分析. 13和皂苷20.在不同的反应条件下,使用衍生自11的螺固醇的立体模型推导了假皂甙元和假皂甙的c-22侧链的闭环反应机理.皂苷二糖苷3,4,20,
DOI:10.1016/s0223-5234(00)00151-3
海关参考信息
- 2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇
2905399001-1,3-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-8361516-B2
优先权日:2006-08-03
标 题:Composition comprising sarsasapogenin
发明人：LINTNER KARL; MAS CHAMBERLIN CLAIRE
权利人:SEDERMA SA; LINTNER KARL; MAS CHAMBERLIN CLAIRE
摘要:The présent invention relates to a composition comprising sarsasapogenin or a plant extract containing it in order to improve the gêneral state of the skin and in particular to improve and/or embellish any part of the body showing a déficit in lipids. More particularly, the invention is directed to a cosmetic method to improve the figure, comprising the step of topically applying to the skin a cosmetic or dermopharmaceutical composition comprising sarsasapogenin to favour the expansion and/or the formation of the subcutaneous adipose tissue, and/or to favour the lipid synthesis in the epidermis.
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主要参考文献
1: Zhu L, Wang Z, Zhai X, Sui Z, Wang D, Li Q, Bi K, He B, Wang T. Simultaneous quantitative determination of 13 active components in the traditional Chinese medicinal preparation Suanzaoren oral liquid by HPLC coupled with diode array detection and evaporative light scattering detection. J Sep Sci. 2017 Mar 31. doi: 10.1002/jssc.201700061. [Epub ahead of print] doi: 10.1038/srep38757.
3: Jung O, Lee J, Lee YJ, Yun JM, Son YJ, Cho JY, Ryou C, Lee SY. Timosaponin AIII inhibits migration and invasion of A549 human non-small-cell lung cancer cells via attenuations of MMP-2 and MMP-9 by inhibitions of ERK1/2, Src/FAK and β-catenin signaling pathways. Bioorg Med Chem Lett. 2016 Aug 15;26(16):3963-7. doi: 10.1016/j.bmcl.2016.07.004. Epub 2016 Jul 4. doi: 10.1016/j.etap.2016.06.012. Epub 2016 Jun 14. doi: 10.1007/s12272-016-0763-3. Epub 2016 Jun 8. doi: 10.1080/14786419.2016.1169416. Epub 2016 Apr 7. doi: 10.3892/ijo.2016.3423. Epub 2016 Mar 7. Chinese. Chinese. doi: 10.1111/cas.12852. Epub 2016 Jan 22.
11: Tundis R, Bonesi M, Menichini F, Loizzo MR. Recent Knowledge on Medicinal Plants as Source of Cholinesterase Inhibitors for the Treatment of Dementia. Mini Rev Med Chem. 2016;16(8):605-18. Review. doi: 10.1016/j.jchromb.2015.06.015. Epub 2015 Jun 19. doi: 10.3390/molecules200711777. doi: 10.3390/molecules20046700. doi: 10.1016/j.intimp.2015.02.016. Epub 2015 Feb 16. doi: 10.1007/s13277-014-2985-7. Epub 2014 Dec 27. doi: 10.1038/aps.2014.65. Epub 2014 Aug 4.
合成参考文献
摘要:Chen Q, Hu Y, Xia Z. [The effects of ZMS on learning and memory ability and brain choline acetyltransferase in scopolamine-induced mouse model]. Zhong Yao Cai. 2001 Jul;24(7):496–8.
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