CAS: 3913-50-6; 2-Oxo-3-(Phosphonooxy)Propanoic Acid

上下游产品

D-(-)-3-phosphoglyceric acid L-phosphoserine

📜D-(-)-3-Phosphoglyceric Acid置于entamoeba Histolytica D-Phosphoglycerate Dehydrogenase,2-环己胺基乙磺酸,β-烟酰胺腺嘌呤二核苷酸,1,4-Dithiothreitol体系中,用 水 作为反应溶剂,化学反应 0.05H,反应生成 3-羟基-2,2-二甲氧基-丙酸-3-磷酸三(环己胺)盐
参考文献:Crystal Structures And Kinetics Of Type Iii 3-Phosphoglycerate Dehydrogenase Reveal Catalysis By Lysine
标题:Crystal Structures And Kinetics Of Type Iii 3-Phosphoglycerate Dehydrogenase Reveal Catalysis By Lysine
摘要:D‐phosphoglycerate Dehydrogenase (Pgdh) Catalyzes The First Committed Step Of The Phosphorylated Serine Biosynthesis Pathway. Here,We Report For The First Time,The Crystal Structures Of Type Iiik Pgdh From Entamoeba Histolytica In The Apo Form,As Well As In Complexes With Substrate (3‐phosphoglyceric Acid) And Cofactor (Nad+) To 2.45,1.8 And 2.2 å Resolution,Respectively. Comparison Of The Apo Structure With The Substrate‐bound Structure Shows That The Substrate‐binding Domain Is Rotated By ~ 20° To Close The Active‐site Cleft. The Cofactor‐bound Structure Also Shows A Closed‐cleft Conformation,In Which Nad+ Is Bound To The Nucleotide‐binding Domain And A Formate Ion occupies The Substrate‐binding Site. Superposition Of The Substrate‐ And Cofactor‐bound Structures Represents A Snapshot Of The Enzyme In The Active Form,Where C2 Of The Substrate And C4N Of The Cofactor Are 2.2 å Apart,And The Amino Group Of Lys263 Is Close Enough To The Substrate To Remove The Proton From The Hydroxyl Group Of Pga,Indicating The Role Of Lys In The Catalysis. Mutation Of Lys263 To Ala Yields Just 0.8% Of The Specific Activity Of The Wild‐type Enzyme,Revealing That Lys263 Indeed Plays An Integral Role In The Catalytic Activity. The Detectable Activity Of The Mutant,However,Indicates That After 20° Rotation Of The Substrate‐binding Domain,The Resulting Positions Of The Substrate And Cofactor Are Sufficiently Close To Make A Productive Reaction.Databasethe Atomic Coordinates And Structure Factors Have Been Deposited In The Protein Data Bank,Www.Pdb.Org (Pdb Id Code 4Nfy,4Njm And 4Njo)Structured Digital Abstract Ehpgdh And Ehpgdh Bind By X-Ray Crystallography (View Interaction) Ehpgdh And Ehpgdh Bind By Molecular Sieving (View Interaction)
DOI:10.1111/febs.13091

专利信息

专利号:US-2009191610-A1
优先权日:2005-08-18
标 题 :Microorganisms With Increased Efficiency for Methionine Synthesis
发明人：ZELDER OSKAR; HEROLD ANDREA; KLOPPROGGE CORINNA; SCHRODER HARTWIG; HAEFNER STEFAN; HEINZLE ELMAR; WITTMANN CHRISTOPH; KROEMER JENS; PERO JANICE G; YOCUM R ROGERS; PATTERSON THOMAS A; WILLIAMS MARK; HERMAN THERON
权利人:EVONIK DEGUSSA GMBH
摘要:The present invention relates to methods for the production of microorganisms with increased efficiency for methionine synthesis, microorganisms with increased efficiency for methionine synthesis, and methods for determining the optimal metabolic flux for organisms with respect to methionine synthesis.

专利号:US-2024336679-A1
优先权日:2021-08-06
标题 :Methods for the treatment of cancer
发明人：LINARES LÆTITIA; FIRMIN NELLY; MANTEAUX GABRIELLE
权利人:INST REGIONAL CANCER MONTPELLIER; INST NAT SANTE RECH MED; UNIV MONTPELLIER
摘要:The present disclosure relates to an Interleukin-6 (IL-6) signaling inhibitor selected from an IL-6 inhibitor, an IL-6 receptor inhibitor, an IL-6/IL-6 receptor complex inhibitor, a gp130 inhibitor and a STAT3 inhibitor or a pharmaceutical composition comprising such an IL-6 signaling inhibitor. for use in a method for treating and/or preventing cancer in a subject in need thereof. wherein the subject has been previously classified as being affected with a cancer exhibiting recruitment of MDM2 to chromatin. The inventors have observed that cancers exhibiting recruitment of MDM2 to chromatin have been shown to secrete IL-6 that in turn acts on myoblast cells to activate serine synthesis. Following these surprising and unexpected observations. the inventors set up methods of treatment that are able to induce cancer cells death in subjects that have been previously classified as being affected with a cancer exhibiting recruitment of MDM2 to chromatin.

专利号:US-2015317458-A1
优先权日:2012-12-06
标 题 :In silico prediction of enhanced nutrient content in plants by metabolic modelling
发明人：LOTZ KATRIN; LEPS MICHAEL; LEMKE RAINER; JUNKER BJOERN; SCHREIBER FALK
权利人:BASF PLANT SCIENCE CO GMBH
摘要:The present invention relates to a method for identifying at least one metabolic conversion step, the modulation of which increases the amount of a metabolite of interest in a plant cell, plant or plant part, said method comprising establishing a stoichiometric network model for the metabolism of the plant cell, plant or plant part including the synthesis pathway for the metabolite of interest, identifying at least one candidate metabolic conversion step by applying at least one algorithm of Growth-coupled Design, and validating the at least one candidate metabolic conversion step by a constraint-based modeling approach in the stoichiometric network model, wherein an increase in the metabolite of interest occurring in said constraint-based modeling approach is indicative for a metabolic conversion step, the modulation of which increases the amount of the metabolite of interest in the plant cell, plant or plant part. The present invention further relates to a method for generating a plant cell, plant or plant part which produces an increased amount of a metabolite of interest when compared to a control, said method comprising identifying a metabolic conversion step, the modulation of which increases a metabolite of interest in a plant cell, plant or plant part, by the method for identifying a metabolic conversion step and modulating the said metabolic conversion step such that the amount of the metabolite of interest is increased in vivo in a plant cell, plant or plant part.

专利号:WO-2014004625-A1
优先权日:2012-06-26
标题:Microorganisms for producing ethylene glycol using synthesis gas
发明人：OSTERHOUT ROBIN E; BURGARD ANTHONY P; BURK MARK J
权利人:GENOMATICA INC
摘要:The invention provides a non-naturally occurring microbial organism containing an ethylene glycol pathway, wherein the pathway includes at least one exogenous nucleic acid encoding an ethylene glycol pathway enzyme expressed in a sufficient amount to produce ethylene glycol. The non-naturally occurring microorganisms of the invention can express exogenous nucleic acids that catalyze the fixation of C02 or CO to ethylene glycol. The microorganisms of the invention can further include enzymes to generate energy and reducing equivalents from methanol, syngas and other gaseous sources. The invention additionally provides methods of using such microbial organisms to produce ethylene glycol, by culturing a non-naturally occurring microbial organism containing an ethylene glycol pathway under conditions and for a sufficient period of time to produce ethylene glycol.

专利号:BR-PI0614891-A2
优先权日:2005-08-18
标 题:method, device and program element for determining an organism with increased efficiency for methionine synthesis, computer readable medium, method for producing an organism, organism, methods for producing a microorganism of corynebacterium genus and escherichia genus with increased production efficiency methionine, microorganisms of the genus corynebacterium and escherichia, use of either organism, and method to produce methionine