CAS: 344-14-9; Dimethyl 2-Fluoromalonate

上下游产品

CAS号108-59-8 丙二酸二甲酯 | CAS号78948-09-1 acetyl hypofluorite | CAS号67-56-1 甲醇 | CAS号120131-06-8 2-fluoro-1,1,3,... | CAS号79546-70-6 methyl 3-chloro... | CAS号382-93-4 2,3,3,3-四氟丙酸甲酯 | CAS号124-41-4 甲醇钠 | CAS号27931-91-5 dimethyl (hydro... | CAS号77778-66-6 METHYL 2-FLUORO... | CAS号139590-63-9 2-Fluoro-3-meth... | CAS号1598-63-6 5-氟-2-甲基-4,6-二羟基嘧啶 | CAS号112854-12-3 methyl 2-fluoro... | CAS号669-96-5 4(3H)-Pyrimidin... | CAS号83049-85-8 dimethyl 2-(flu... | CAS号453-09-8 2-fluoropropane... | CAS号473-87-0 2-氟丙二酸

丙二酸二甲酯置于铀(Vi)氟化物体系中,用 1,1,2-三氯三氟乙烷(cfc-113) 用作溶剂,化学反应 20.0H,以15%的收率获得2-氟丙二酸二甲酯
参考文献:(再)研究六氟化铀在室温下对几种有机功能的反应性
标题:(再)研究六氟化铀在室温下对几种有机功能的反应性
摘要:全球每年生产uf的6是非常大的,而不是使用这种化合物.因此,它可能是有趣的发现一些应用有机试剂.Uf 6可以被认为是各种功能的氧化剂.但是,在温和的条件下作为氟化试剂似乎也存在一些可能性.
Doi:10.1016/j.Jfluchem.2014.06.007

专利信息

专利号:WO-2021031168-A1
优先权日:2019-08-21
标 题:Continuous synthesis method for 2-fluoromalonic acid diester compound
发明人：HONG HAO; LU JIANGPING; BAO DENGHUI; LIU CHAOJIE; CAI XUEDONG; JIA XIAOTONG
权利人:ASYMCHEM LIFE SCIENCE TIANJIN CO LTD
摘要:Provided is a continuous synthesis method for a 2-fluoromalonic acid diester compound. The method comprises: using (I) as a raw material, and carrying out continuous decarbonylation reaction in a continuous reaction device to obtain 2-fluoromalonic acid diester compound (II), wherein R and R' respectively represent unbranched or branched alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclic or cyclic alkyl, and R and R' are the same or different. Compared with the traditional kettle reaction, the amount of materials involved in the reaction per unit time is decreased and the high-temperature dangerous area is reduced in the synthesis method, thereby greatly lowering the safety risk.

专利号:CA-2952530-A1
优先权日:2014-06-18
标题:Synthesis of halogenated malonic acid diesters and use thereof in the synthesis of 2-halogen-acrylic acid esters

专利号:US-12441677-B2
优先权日:2019-11-14
标 题 :One step synthesis for alkyl 2-fluoroacrylates
发明人：JIN QINGWU; WHITACRE MICHAEL
权利人:VIFOR INT LTD
摘要:A process is provided that results in an alkyl haloacrylate that is produced by reaction of a dialkyl or diaryl halomalonate with an aldehyde, preferably formalin or paraformaldehyde, and a base catalyst to produce an intermediate that is not isolated and is heated to produce the alkyl haloacrylate. This synthesis can be one pot, meaning it reacts in the same vessel and/or reaction mixture and does not require isolation of the intermediate, and provides an improved yield. In particular, a process is provided that results in an alkyl 2-fluoroacrylate.

专利号:US-8618312-B2
优先权日:2008-05-21
标题:Method of producing bicyclo[3.1.0] hexane derivative using enzyme
发明人：HIROTSUKA MITSUAKI; SASAKI JOJI; KAMIYAMA HIROAKI; OSHIDA MOTOKO; ISHII TAKAAKI
权利人:HIROTSUKA MITSUAKI; SASAKI JOJI; KAMIYAMA HIROAKI; OSHIDA MOTOKO; ISHII TAKAAKI; TAISHO PHARMACEUTICAL CO LTD
摘要:Production of a bicyclo[3.1.0]hexane derivative, useful as a metabotropic glutamate receptor modulator, becomes possible by a production method that includes converting a compound represented by Formula (II) into a compound represented by Formula (III) by reaction with an acyl group donor in the presence of a microorganism-derived enzyme, without using an expensive optically active trans hydroxy ester as a starting material and without employing a fluorination reaction requiring an ultralow temperature reaction. Furthermore, since asymmetric synthesis can be carried out in a stage closer to the final product, the production method is useful as a production method that can mass produce a bicyclo[3.1.0]hexane derivative.

专利号:CN-114867710-A
优先权日:2019-11-14
标题:One-step Synthesis of 2-Fluoroalkyl Acrylates

专利号:CN-104496737-B
优先权日:2014-12-13
标 题:A kind of method of synthesis α amine formyl ethyl fluoroacetate compounds