CAS: 27013-91-8; (4As,6As,6Br,8Ar,9R,10S,12Ar,12Br,14Bs)-10-(((2S,3R,4S,5S)-4,5-Dihydroxy-3-(((2S,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)Tetrahydro-2H-Pyran-2-yl)Oxy)-9-(Hydroxymethyl)-2,2,6A,6B,9,12A-Hexamethyl-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10

该化合物是沙朋因之间常见的特性;其结构由糖浆组成,与类固醇或丙烯三烯相联,有助于其生物活动;已研究乙酰丙胺的潜在治疗用途,特别是呼吸卫生用途,并可能因其对血液循环的影响而对心血管健康产生影响;然而,有必要开展进一步的研究,以充分阐明其行动和治疗潜力的机制.与许多天然化合物一样,在广泛使用之前,应对肝氧丙胺的安全和功效在临床环境中进行评估.

结构式图片

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上下游产品

dipsacoside B 2)-O-α-L-arabinopyranosyl-28-O-α-L-rhamnopyranosyl-(1->4)-O-6-O-acetyl-β-D-glucopyranosyl-(1->6)-O-β-D-glucopyranosyl esterhederagenin-3-O-α-L-rhamnopyranosyl-(1-2)-O-α-L-arabinopyranosyl-28-O-α-L-rhamnopyranosyl-(1-4)-O-6-O-acetyl-β-D-glucopyranosyl-(1-6)-O-β-D-glucopyranosyl ester HN-saponin P 3)-α-L-rhamnopyranosyl-(1->2)-α-L-arabinopyranosidehederagenin 3-O-α-L-arabinofuranosyl-(1-3)-α-L-rhamnopyranosyl-(1-2)-α-L-arabinopyranoside hedaragenin prosapogenin 3-O-alpha-L-arabinopyranoside hederagenin hederagenin

合成工艺路线路线简述

    📜3-O-α-L-Rhamnopyranosyl-(1->2)-α-L-Arabinopyranosyl Hederagenin-28-O-β-D-Galactopyranosyl-(1->6)-β-D-Glucopyranosyl Ester置于potassium Hydroxide,盐酸体系中,用 水 用作溶剂,化学反应 2.0H,反应生成Alpha-常春藤苷
    参考文献:Antimicrobially Active Hederagenin Glycosides From Cephalaria Elmaliensis
    标题:Antimicrobially Active Hederagenin Glycosides From Cephalaria Elmaliensis
    摘要:A Phytochemical Investigation Of The Aerial Parts Of Cephalaria Elmaliensis Resulted In The Isolation Of Ten Hederagenin-Type Triterpene Saponins (1-10) Including Three New Ones,Elmalienoside A (1),Elmalienoside B (2),Elmalienoside C (3),And Two Known Flavonoid Glycosides (11-12). Their Structures Were Identified By Extensive Spectroscopic Techniques (1D And 2D NMR,Hr Esims) And Chemical Evidence. The Antimicrobial Activity Of The Extracts And The Pure Compounds Was Evaluated By The Mic Method. According To The Results,All Pure Compounds Including The New Ones Were Found To Be Very Active Against Both Gram-Positive And Gram-Negative Bacteria.
    Doi:10.1055/s-0031-1298415

    专利信息


    专利号:BR-112016022455-B1
    优先权日:2014-03-31
    标 题 :use of a supernatant from cultures of a strain of bacillus pumilus species, unnatural cosmetic or dermopharmaceutical composition; skin, stimulate collagen synthesis and / or hyaluronic acid synthesis, treatment of skin tightening and / or prevention of loss of skin firmness

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Li J, Wu DD, Zhang JX, Wang J, Ma JJ, Hu X, Dong WG. Mitochondrial pathway mediated by reactive oxygen species involvement in α-hederin-induced apoptosis in hepatocellular carcinoma cells. World J Gastroenterol. 2018 May 7;24(17):1901-1910. doi: 10.3748/wjg.v24.i17.1901.
    2: Tabassum H, Ahmad A, Ahmad IZ. Nigella sativa L. and Its Bioactive Constituents as Hepatoprotectant: A Review. Curr Pharm Biotechnol. 2018;19(1):43-67. doi: 10.2174/1389201019666180427110007. doi: 10.1016/j.biopha.2018.02.062. Epub 2018 Feb 23. doi: 10.3892/ol.2017.5884. Epub 2017 Mar 21.
    5: Wu AG, Zeng W, Wong VK, Zhu YZ, Lo AC, Liu L, Law BY. Hederagenin and α-hederin promote degradation of proteins in neurodegenerative diseases and improve motor deficits in MPTP-mice. Pharmacol Res. 2017 Jan;115:25-44. doi: 10.1016/j.phrs.2016.11.002. Epub 2016 Nov 9. Epub 2016 Aug 30. doi: 10.1002/ddr.21292. Epub 2016 Feb 10. doi: 10.1038/srep17904.

    合成参考文献


    摘要:Annales Pharmaceutiques Francaises., 38(545), 1980 []
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