CAS: 24915-95-5; Ethyl (R)-3-Hydroxybutyrate

相似化合物

5405-41-4 56816-01-4 82578-45-8

上下游产品

3-羟基丁酸乙酯 Ethyl (S)-3-Hydroxybutanoate 5405-41-4
(S)-3-羟基丁酸乙酯 3-Hydroxobutyric Acid Ethyl Ester 56816-01-4
乙酰乙酸乙酯 Ethyl Acetoacetate 141-97-9
(R)-3-羟基丁酸 (R)-3-Hydroxybutyrate 625-72-9
(R)-4-Methyloxetan-2-One 32082-74-9

乙酰乙酸乙酯置于dimethyl Sulfide Borane体系中,用 四氢呋喃 用作溶剂,化学反应 0.17H,反应生成(R)-(-)-3-羟基丁酸乙酯
参考文献:新型手性三配位磷硼烷配合物在酮的对映选择性硼烷还原中的应用:配合物的结构和机理研究
标题:新型手性三配位磷硼烷配合物在酮的对映选择性硼烷还原中的应用:配合物的结构和机理研究
摘要:合成了新的三配位硼硼烷配合物,并研究了其作为催化剂用于手性芳族和脂肪族酮的对映选择性硼烷还原的作用.(2 R,5 S)-2-邻-茴香基-3-氧杂-1-氮杂磷双环[3.3.0]辛烷-硼烷配合物1B和(2 R,5 S)-2,3-二苯基-的结构1,3-二氮杂磷双环[3.3.0]辛烷-硼烷络合物6A通过x射线衍射分析确定.氧杂氮磷硼烷硼烷配合物的结构与在还原苯乙酮中所获得的对映选择性之间存在关系,二者均用2Mol%和1当量的催化剂.在所测试的不同的氧杂氮杂膦硼烷配合物中,只有配合物1-3(包括3-氧杂-1-氮杂磷杂双环[3.3.0]辛烷和3-氧杂-1-杂氮杂双环[4.3.0]壬烷部分)是有效的催化剂.根据实验结果,尤其是氘标记研究,提出了一种合理的机理.
Doi:10.1016/s0022-328X(96)06614-4

专利信息

专利号:WO-2014097257-A1
优先权日:2012-12-21
标 题:A method of preparation of (1'r,3r,4r)-4-acetoxy-3-(1'-(tert-butyldimethylsilyloxy)ethyl)-2-azetidinone, a precursor for carbapenem antibiotics synthesis
发明人：GRZESZCZYK BARBARA; STECKO SEBASTIAN; FURMAN BARTÅ?OMIEJ; CHMIELEWSKI MAREK
权利人:INST CHEMII ORGANICZNEJ PAN
摘要:The subject of the present invention is a method of preparation of (1'R,3R,4R)-4-acetoxy-3-(1'- (tert-butyl-dimethylsilyloxy)ethyl)-2-azetidinone defined by the formula (1) which is a basic chiral building block in the synthesis of carbapenem antibiotics.

专利号:US-12037317-B2
优先权日:2018-01-25
标 题:Synthesis of 3-hydroxybutyryl 3-hydroxybutyrate and related compounds
发明人：ULRICH SCOTT MICHAEL
权利人:BUCK INST RES AGING
摘要:In various embodiments methods of preparing hydroxybutyryl 3-hydroxybutyrate and related compounds are provided along with methods of use thereof.

专利号:US-2024317671-A1
优先权日:2018-01-25
标题 :Synthesis of 3-hydroxybutyryl 3-hydroxybutyrate and related compounds

专利号:WO-2009075823-A1
优先权日:2007-12-07
标题:Intermediates in the synthesis of zearalenone macrolide analogs

专利号:CA-2708143-A1
优先权日:2007-12-07
标题 :Intermediates in the synthesis of zearalenone macrolide analogs

专利号:US-8507696-B2
优先权日:2007-12-07
标 题:Intermediates in the synthesis zearalenone macrolide analogs
发明人：FANG FRANCIS G; NIU XIANG; SCHNADERBECK MATTHEW J
权利人:FANG FRANCIS G; NIU XIANG; SCHNADERBECK MATTHEW J; EISAI R&D MAN CO LTD
摘要:Disclosed herein are methods and intermediates useful in the preparation of macrolides, e.g., compounds of formula (IV), wherein R 1 -R 12 are as defined herein.