CAS: 17238-66-3; Morpholine-4-Carboximidamide

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上下游产品

CAS号110-91-8 吗啉 | CAS号867-44-7 |S|-甲基异硫脲硫酸盐 | CAS号5638-78-8 吗啉-4-甲脒盐酸盐 | CAS号38184-47-3 3,5-二甲基吡唑-1-硝酸咪 | CAS号2986-19-8 2-甲基-2-疏基硫酸脲 | CAS号625-57-0 O-乙基硫代氨基甲酸酯 | CAS号34750-23-7 4-氯-2-吗啉嘧啶-5-羧酸乙酯 | CAS号24193-00-8 2-吗啉嘧啶-4,6-二醇 | CAS号10397-13-4 2-吗啉基-4,6-二氯嘧啶 | CAS号61466-28-2 2-morpholin-4-y...

吗啉-4-羧酰胺置于乙醇,Sodium体系中,化学反应 0.5H,反应生成吗啉-4-甲脒
参考文献:ber N1-Und N2-Substituierte 2-Amino-5,6-Dihydro-4(1H)-Pyrimidinone
标题:ber N1-Und N2-Substituierte 2-Amino-5,6-Dihydro-4(1H)-Pyrimidinone
摘要:
Doi:10.1007/bf00798460

专利信息

专利号:US-11584773-B2
优先权日:2014-04-30
标 题:Phosphorous protecting groups and methods of preparation and use thereof
发明人：DELLINGER DOUGLAS J; MONFREGOLA LUCA; CARUTHERS MARVIN; ROY MITHUN
权利人:AGILENT TECHNOLOGIES INC
摘要:Aspects of the present disclosure include compositions that make use of phosphorus and/or nucleobase protecting groups which find use in the synthesis of long polynucleotides. Phosphorus protecting groups are provided that help increase the stepwise coupling yield and/or phosphorous protecting groups that can be removed during the oxidation step. Amidine nucleobase protecting groups are provided that find use in the subject compositions and methods which provides for e.g., increased resistance to depurination during polynucleotide synthesis. In some instances, the methods and compositions disclosed herein utilize a combination of the phosphorus and amidine nucleobase protecting groups in the synthesis of polynucleotides having a sequence of 200 or more monomeric units in length. Also provided are methods for synthesizing a polynucleotide (e.g., a DNA) using one or more compounds disclosed herein.

专利号:US-10072261-B1
优先权日:2016-03-25
标 题 :Double coupling method for oligonucleotide synthesis
发明人：MYERSON JOEL; CHEN SIYUAN
权利人:AGILENT TECHNOLOGIES INC
摘要:Aspects of the present disclosure include methods for double coupling a nucleoside phosphoramidite during synthesis of an oligonucleotide. The method can include coupling a free hydroxyl group of a nucleoside residue with a first sample of a protected nucleoside phosphoramidite via an internucleoside P(III) linkage, followed by exposure to an oxidizing agent prior to a second coupling step with a second sample of the protected nucleoside phosphoramidite, and further exposure to an oxidizing agent. The method finds use in synthesizing an oligonucleotide on a solid phase support, such as a planar surface. The double coupling method can be utilized at one or more nucleotide positions during oligonucleotide synthesis thereby reducing single base deletion rates. Oligonucleotide containing compositions synthesized according to the disclosed methods are also provided.

专利号:US-9802975-B2
优先权日:2014-06-10
标题:Protecting groups for “Z nucleotide†and methods thereof
发明人：LUNSTAD BENJAMIN D; DELLINGER DOUGLAS J
权利人:AGILENT TECHNOLOGIES INC
摘要:The present disclosure provides nucleoside compounds and oligonucleotides including an unnatural 6-amino-2-pyridone heterocyclic base where the 6-amino and 2-positions are protected. The 2-position of the heterocyclic base can be protected with an acyl-oxy-methyl protecting group. In some embodiments, the protected heterocyclic base has the following structure where AcOM is an acetyl-oxy-methyl group and R is a ribose or deoxyribose sugar: n n n n n n n n n n Methods for synthesizing an oligonucleotide are provided in which the subject compounds find use. The method can include protecting an unnatural (e.g., Z) nucleotide with an acetyl-oxy-methyl group; incorporating the protected unnatural nucleotide into a nucleotide sequence on a solid support; and removing the acetyl-oxy-methyl group from the unnatural nucleotide incorporated into the nucleotide sequence. The compounds and methods find use in the synthesis of long oligonucleotides including Z nucleotides.

专利号:WO-9724361-A1
优先权日:1995-12-29
标 题 :Nucleotide analogs
发明人：ARIMILLI MURTY N; BISCHOFBERGER NORBERT W; JONES ROBERT J; LEE WILLIAM A; PRISBE ERNEST J
权利人:GILEAD SCIENCES INC; ARIMILLI MURTY N; BISCHOFBERGER NORBERT W; JONES ROBERT J; LEE WILLIAM A; PRISBE ERNEST J
摘要:Nucleotide phosphonate esters characterized by the presence of an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise an ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.

专利号:RU-2099323-C1
优先权日:1990-05-17
标 题:Guanidine derivatives, a method of their synthesis and pharmaceutical composition showing hypoglycemic activity