专利号:US-2024239791-A1 优先权日:2021-04-26 标题 :Processes for the synthesis of valbenazine 发明人:TUCKER JOHN LLOYD 权利人:NEUROCRINE BIOSCIENCES INC 摘要:The present application relates to processes for preparing (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate), which is an inhibitor of vesicular monoamine transporter 2 (VMAT2) useful in the treatment of hyperkinetic movement disorders such as tardive dyskinesia (TD).
专利号:US-2022363680-A1 优先权日:2019-09-13 标题 :Processes for the synthesis of valbenazine 发明人:TUCKER JOHN; KUCERA DAVID; HETTINGER DONALD; COCHRAN BRIAN M; BRANUM SHAWN; LE JACKIE; MCGEE KEVIN 权利人:NEUROCRINE BIOSCIENCES INC 摘要:The present application relates to processes for making (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b -hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl (S)-2-amino-3-methylbutanoate di(4-methylbenzenesulfonate), which is an inhibitor of vesicular monoamine transporter 2 (VMAT2) useful in the treatment of hyperkinetic movement disorders such as tardive dyskinesia (TD).
专利号:US-7576240-B2 优先权日:2006-04-26 标 题 :Arylamine processes 发明人:MURPHY LEANNE DAWN 权利人:XEROX CORP 摘要:Processes for selectively hydrogenating double and/or triple bonds in organic molecules include providing at least one organic molecule containing a double and/or triple bond, providing at least one hydrogen donor molecule, and hydrogenating the double and/or triple bond in the presence of at least one catalyst. Processes for preparing arylamine molecules include selectively hydrogenating double bonds in arylamine compounds by providing at least one organic molecule containing a multiple bond, providing at least one hydrogen donor molecule, and hydrogenating the multiple bond in the presence of at least one catalyst. The processes provide efficient, cost-effective and safe methods for conducting selective hydrogenation reactions in the synthesis of organic molecules, such as charge-transport molecules.
专利号:US-2008076049-A1 优先权日:2006-09-26 标 题 :Arylamine processes 发明人:SABAN MARKO D; MURPHY LEANNE DAWN; ENRIGHT THOMAS EDWARD 权利人:XEROX CORP 摘要:Continuous and batch processes for selectively hydrogenating double and/or triple bonds in organic molecules include providing at least one organic molecule containing a double and/or triple bond, providing at least one hydrogen donor molecule, and hydrogenating the double and/or triple bond in the presence of at least one catalyst. Continuous and batch processes for preparing arylamine molecules include selectively hydrogenating double bonds in arylamine compounds by providing at least one organic molecule containing a multiple bond, providing at least one hydrogen donor molecule, and hydrogenating the multiple bond in the presence of at least one catalyst. The continuous and batch processes provide efficient, cost-effective and safe methods for conducting selective hydrogenation reactions in the synthesis of organic molecules, such as charge-transport molecules.
专利号:WO-2022232060-A1 优先权日:2021-04-26 标 题:Processes for the synthesis of valbenazine
专利号:WO-2009143405-A2 优先权日:2008-05-22 标 题:Synthesis of graphene sheets and nanoparticle composites comprising same
参考标题:Carbapenams And Carbapen-2-Ems And Process Therefor 摘要:Carbapenam-3-Carboxylic Acids And Carbapen-2-Em-3-Carboxylic Acids Substituted At The 1-Position With An Oxo, A Hydroxy Or An Acetoxy Group, Variously Substituted At The 2-Position With Such Groups As Methyl, Acetoxymethyl, Methanesulfonyloxy, Alkoxy, Alkylthio, Aminoalkylthio Or Amidinoalkylthio And Optionally Substituted At The 6-Position With A Hydroxyalkyl Group, An Acetoxyalkyl Group Or A Conventional Penicillin Side-Chain, Pharmaceutically-Acceptable Salts Thereof And Various Esters Thereof Wherein The Esterifying Group Is Selectively Removed In The Laboratory, Or Hydrolyzed Under Physiological Conditions. These Compounds Are Useful Either Systemically Or Topically In The Treatment Of Diseases Caused By Susceptible Microorganisms, As Animal Feed Additives For Promotion Of Growth, Or In The Preservation Of Biodegradable Materials, Or As Intermediates To Compounds Having Such Antibacterial Activity. Key To The Synthesis Of These Compounds Is The Light Catalyzed Rearrangement Of 2-Diazo-1-Oxoceph-3-Em-4-Carboxylates To 1-Oxocarbapen-2-Em-3-Carboxylates, A Newly Discovered Reaction Determined To Be Of General Applicability.
合成参考文献
摘要:National Technical Information Service., ORNL-5576