专利号:EP-2173747-B1 优先权日:2007-06-26 标 题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles 发明人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; R KYEN OMAR; URMANN MATHIAS; HALLAND NIS 权利人:SANOFI SA 摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present invention provides a direct metal, e.g. palladium or copper, catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.
专利号:US-2010261909-A1 优先权日:2007-06-26 标题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
专利号:WO-2009000413-A1 优先权日:2007-06-26 标题:A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
专利号:EP-2173721-B1 优先权日:2007-06-26 标 题:A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
专利号:EP-2173721-A1 优先权日:2007-06-26 标题:A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
专利号:WO-2009000412-A1 优先权日:2007-06-26 标题:A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles
[参考文献]: C Cejka 1, Et Al. Central Corneal Thickness Considered An Index Of Corneal Hydration Of The Uvb Irradiated Rabbit Cornea As Influenced By Uvb Absorber. Physiol Res. 2012;61(3):299-306.