CAS: 13139-86-1; 4-Methoxyphenylmagnesium Bromide

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1-bromo-4-methoxy-benzene 7-chloro-1,2,3,4,4a,9b-hexahydro-2-methyl-5H-1,3-ethanoindeno-[1,2-c]pyridin-5-one 1,10-Phenanthroline ethylene dibromide 2-methoxyphenethyl alcohol 2-(4-Methoxyphenyl)ethanol 5-(4-methoxyphenyl)pentan-1-al 2,2-bis(4-methoxyphenyl)tetrahydrofuran

4-溴苯甲醚置于magnesium,Lithium Chloride体系中,用 四氢呋喃 用作溶剂,化学反应生成4-甲氧基苯基溴化镁
参考文献:使用有机镁试剂进行铬 (II) 催化的非对映选择性和化学选择性 Csp2-Csp3 交叉偶联
标题:使用有机镁试剂进行铬 (II) 催化的非对映选择性和化学选择性 Csp2-Csp3 交叉偶联
摘要:已开发出一种在环境温度下用环己基碘对芳基镁卤化物进行铬催化的高度非对映选择性烷基化的简单方案.此外,这种不含配体的 Crcl2 能够使伯,仲和叔烷基卤化镁与容易获得的乙酸烯基酯进行有效的亲电烯基化.此外,这种与立体定义的烯基乙酸酯的化学选择性 C-C 偶联反应以立体保留方式进行.烷基碘化物和烯基乙酸酯上的各种官能团具有非常好的耐受性,从而以非常好的收率和高非对映选择性提供官能化的 Csp2-Csp3 偶联产物.详细的机理研究表明,原位生成的低价铬 (I) 物种可能是这些 Csp2-Csp3 交叉偶联的活性催化剂.
Doi:10.1021/jacs.9B08586

专利信息

专利号:US-7956011-B2
优先权日:2005-05-04
标题:Materials and methods for the photodirected synthesis of oligonucleotide arrays
发明人：SERAFINOWSKI PAWEL JERZY; GARLAND PETER BRYAN
权利人:CANCER RES INST ROYAL
摘要:Materials and methods for photodirected synthesis of oligonucleotide arrays on a solid substrate by photodirected synthesis are disclosed which employ a film formed from (i) a photoacid generator that on photolysis generates acid that is capable of directly removing the protecting group of the linker molecules or oligonucleotides and (ii) a polymer substantially lacking electronegative heteroatoms that are capable of hydrogen bonding with photogenerated acid. Methods of synthesizing an oligomer arrays are also described that use a film that restricts diffusion of reactants and products on the substrate during synthesis of the array and which includes a precursor of a deprotecting reagent. The method involves removing one or more of the non-required products of the deprotection reaction from the reactive array elements at which they are produced during the reaction, in order to displace the deprotection reaction towards completion.

专利号:US-9527800-B2
优先权日:2013-10-29
标 题:Process for total synthesis of venlafaxine
发明人：CHAVAN SUBHASH PRATAPRAO; PAWAR KAILASH PRALHAD
权利人:COUNCIL SCIENT IND RES
摘要:There is a need for short, resolution free asymmetric process for synthesis of one isomer of venlafaxine, (−)-venlafaxine. The invention provides a novel, short process of synthesis of (−)-venlafaxine, with yield greater than 50% and ee>99%. This process can be used for racemic synthesis of venlafaxine with overall yield 65%.

专利号:WO-2014011120-A1
优先权日:2012-07-13
标 题 :Endoperoxides, synthesis and uses thereof for the treatment of neoplastic diseases such as cancer
发明人：TAN NGUAN SOON; CHIBA SHUNSUKE
权利人:UNIV NANYANG TECH
摘要:The present invention generally relates to processes and methods for the synthesis of endoperoxide compounds. More specifically, the invention relates to a method for preparing endoperoxide compounds starting from an aryl imine of formula (I) in the presence of a metallic catalyst and oxygen. The present invention also relates to endoperoxide compounds of formula (III) and their pharmaceutically acceptable salts thereof, useful for therapy. All substituents are defined herein. Also disclosed are methods of treating cancer using the compounds of formula (III).

专利号:US-9550719-B2
优先权日:2013-05-09
标题 :Process for the preparation of 3-aryl-2-hydroxy propanoic acid compounds
发明人：MURUGAN MUTHUKRISHNAN; MOHAMMAD MUJAHID
权利人:COUNCIL SCIENT IND RES
摘要:The present disclosure provides a process for synthesis of 3-aryl-2-hydroxy propanoic acid derivatives of formula (S)-1. wherein R 1 represents H or (C 1 -C 5 ) alkyl groups and R 2 represents (C 1 -C 5 ) alkyl groups.

专利号:US-7301049-B2
优先权日:2001-06-21
标 题:Photolabile esters and their uses
发明人：SERAFINOWSKI PAWEL JERZY; GARLAND PETER BRYAN
权利人:CANCER RES INST
摘要:Compounds which are capable of generating acid on photolysis are disclosed, and the uses of these compounds, especially for deprotecting the termini of nucleic acid molecules or peptides during synthesis of arrays. The compounds described herein may be employed in the detritylation of 5′-O-dimethoxytrityl (DMT) protected nucleotides by photolysing the compounds to generate an acid capable of removing the DMT group allowing oligonucleotide arrays to be synthesised using readily available 5′-O-DMT-nucleoside-3′-O-phosphoramidite monomers conventionally used in solid phase nucleic acid synthesis. A method of avoiding the effects of stray light in projection lithography techniques is also disclosed.

专利号:US-2010087634-A1
优先权日:2004-12-30
标 题:Fluorous Oligonucleotide Reagents and Affinity Purification of Oligonucleotides
发明人：BERRY DAVID A; PEARSON WILLIAM H
权利人:BERRY & ASSOCIATES INC
摘要:Fluorous-tagged oligonucleotide reagents and an oligonucleotide purification methodology making use thereof, the method comprising: Synthesizing oligonucleotides using oligonucleotide reagents each bearing at least one fluorous group to yield a mixture of synthesis products and reagents, the mixture including at least one target synthesized oligonucleotide bearing at least one fluorous group; passing the mixture through a separation medium having an affinity for the at least one fluorous group so that the target synthesized oligonucleotide bearing at least one fluorous group is adsorbed by the separation medium; washing the separation medium with at least a first solvent to selectively dissociate therefrom substantially all synthesis products and reagents of the heterogenous mixture other than the at least one target synthesized oligonucleotide bearing at least one fluorous group; and subsequently dissociating the at least one synthesized oligonucleotide from the separation medium, with or without the fluorous group.