CAS: 121-59-5; Carbarsone
该化合物是属于砷化合物类别的有机化合物,主要被确认为作为抗寄生物剂,特别是用于动物某些感染治疗的兽医药物;卡巴松的特点是结构构成,包括一个与碳链相连的砷原子,有助于其生物活动;该化合物一般是白色到白晶状粉,在水中可溶解,便于其在水中施用;由于其含砷成分,卡巴松具有潜在的毒性风险,需要谨慎处理和遵守安全准则;由于对砷暴露和环境影响的关切,许多区域都对其使用进行了管制;与许多砷化合物一样,卡巴松的药理效应和安全特征是正在进行的研究的主题,特别是其效力和在兽医和人类应用方面的潜在副作用.
- 英文名称Carbarsone
- 中文名称卡巴松
- IUPAC名称Arsanilic acid, N-carbamoyl-
- 其它别名Arsanilicacid, N-carbamoyl- (7CI,8CI); Carbarsone (6CI); 4-Carbamylaminophenylarsonicacid; 4-Ureidobenzenearsonic acid; 4-Ureidophenylarsonic acid; Amabevan; Ameban; Amebarsene; Amebarsone; Amibiarson; Aminarson; Aminarsone; Aminoarson; Arsambide; Carb-O-Sep; Carbarson; Fenarsone; Hist°Carb; Kutan; Leucarsone; N-Carbamoylarsanilic acid; N-Carbamylarsanilic acid; Pentarsone; p-Arsonophenylurea; p-Carbamidobenzenearsonic acid; p-Ureidobenzenearsonic acid
- CAS编号121-59-5
- MFCD编号:MFCD00025427
- EINECS号:204-484-6
- FDA UNII编号:8PK70TXE1T
- 分子式:C7H9AsN2O4分子量:260.08
- 产品CID: 298044
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
相似化合物
60006-08-8 99642-25-8 866997-46-8物理性质
- 熔点174°
- 沸点174°
- 闪点 °C
- 密度3>g/ cm3
- pKa:3.78±0.10(预测)
- PSA:112.65
- LogP:-1.2618
- 溶解性DMSO (Slightly), Methanol (Slightly, Sonicated)
- 敏感性An acidic salt of an amide. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.
- 外观形态固体
- 储存条件低温通风干燥环境。
- 产品应用卡巴松有时用于治疗肠道阿摩伊巴病.
MSDS等安全信息
- GHS象形图
- GHS符号GHS06 & GHS09;
注释: Skull and crossbones & Environment - 危险类别急性毒性 类别3(吸入)
急性毒性 类别3(经口)
水生急性毒性 类别1
水生慢性毒性 类别1 - 警示词Danger(危险)
- 危险描述H331 |吸入会中毒.
H301 |吞咽会中毒.
H400 |对水生生物毒性极大.
H410 |对水生生物毒性极大并具有长期持续影响. - 防范说明P261-P280-P302+P352
- UN编号3280.0
- 危险品标志T
- 安全声明Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carcinogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)
欧盟法规
ECHA物质ECHA物质C&L通报REACH预注册上下游产品
p-aminophenylarsonic acid brom°Cyane potassium cyanatep-aminophenylarsonic acid ammonia methylammonium carbonate合成工艺路线路线简述
- 合成目标产物 Carbarsone 主要起始原料 4-Aminophenylarsonic Acid And Cyanogen Bromide
- (文献来源)合成步骤主要原料 4-Aminophenylarsonic Acid 和 Cyanogen Bromide
📜Potassium Cyanate,Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于溶剂黄146体系中,化学反应生成卡巴胂
参考文献:De213155
标题:De213155
海关参考信息
- 2912110000-甲醛
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:CN-101535336-A
优先权日:2006-11-10
标题 :Synthesis of Phthalamide and Its Dimer
专利号:CN-101627049-B
优先权日:2006-11-10
标题 :Synthesis of phthalamides
专利号:JP-2017532282-A
优先权日:2014-10-15
标题 :Method for solid-state thermal synthesis of zeolitic material and zeolite obtained therefrom
专利号:ES-2241487-A1
优先权日:2004-04-02
标 题:PROCEDURE FOR THE SYNTHESIS OF NUCLEOSIDS THROUGH THE USE OF PSYCHROTROPHIC OR PSYCHROTOLERANT MICROORGANISMS.
专利号:CN-114044792-A
优先权日:2021-11-09
标题 :One-step synthesis method of 2-substituted metal iridium heterocarbulone complex
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Peng D, Feng L, Pan Y, Wang Y, Chen D, Wang J, Yuan Z. Development and validation of an indirect competitive enzyme-linked immunosorbent assay for monitoring organoarsenic compounds in edible chicken and pork and feed. Food Chem. 2016 Apr 15;197(Pt A):821-8. doi: 10.1016/j.foodchem.2015.11.055. Epub 2015 Nov 14. doi: 10.1021/es504520w. Epub 2015 Feb 4. Review. doi: 10.1016/j.envint.2014.10.022. Epub 2014 Nov 15. Review. doi: 10.1016/j.ijpddr.2012.08.002. eCollection 2012 Dec. Review.
5: Chen D, Zhang H, Tao Y, Wang Y, Huang L, Liu Z, Pan Y, Peng D, Wang X, Dai M, Yuan Z. Development of a high-performance liquid chromatography method for the simultaneous quantification of four organoarsenic compounds in the feeds of swine and chicken. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Apr 1;879(11-12):716-20. doi: 10.1016/j.jchromb.2011.02.013. Epub 2011 Feb 13. Spanish. Russian.
合成参考文献
摘要:Journal of Pharmacology and Experimental Therapeutics., 80(393), 1944
摘要:L20: Wikipedia. Arsenic toxicity. Last Updated 22 February 2009.
摘要:A17: Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. doi: 10.1016/j.jinorgbio.2007.10.021. Epub 2007 Nov 22.
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