CAS: 1196-79-8; 2,5-Dimethyl-1H-Indole

相似化合物

5649-36-5 95-20-5 5621-13-6

上下游产品

5-甲基吲哚 5-Methyl-1H-Indole 614-96-0

3-氯-4-硝基甲苯置于palladium Diacetate,Caesium Carbonate,溶剂黄146,三苯基膦,锌体系中,用 乙醇,甲苯 用作溶剂,化学反应 9.0H,反应生成2,5-二甲基吲哚
参考文献:一般pd催化的逆醛醇/α-芳基化反应合成吲哚,羟吲哚,异香豆素和异喹啉酮†
标题:一般pd催化的逆醛醇/α-芳基化反应合成吲哚,羟吲哚,异香豆素和异喹啉酮†
摘要:该报告中描述了吲哚,羟吲哚,异香豆素和异喹啉酮的不同合成方法,该方法使用一般的pd催化的β-羟基羰基化合物与带有邻-硝基,-酯或-氰基取代基的芳基卤化物串联反应.涉及一个关键的逆醛醇/α-芳基化反应,该反应将经典的pd交叉偶联化学与新型的pd促进的逆醛醇c-c活化相结合,生成α-芳基化的酮或酯.羰基与邻合子的随后分子内缩合得到目标杂环.普通的,可商购的和便宜的底物和催化剂体系的使用为概念上的意义增加了额外的合成优势.
Doi:10.1039/c6Ob01979J

专利信息

专利号:US-8450365-B2
优先权日:2009-05-12
标 题 :Efficient synthesis of galanthamine
发明人：MAGNUS PHILIP D; FAUBER BEN; SANE NEERAJ
权利人:MAGNUS PHILIP D; FAUBER BEN; SANE NEERAJ; UNIV TEXAS
摘要:The present invention relates to methods for the synthesis of galanthamine, morphine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency and overall yield of said morphine, morphine related derivatives and intermediates thereof. In further embodiments, the invention relates to methods for improving the efficiency and overall yield of galanthamine and intermediates thereof.

专利号:US-7786156-B2
优先权日:2004-01-28
标 题 :Synthesis methods and intermediates for the manufacture of Rizatriptan
发明人：MARTIN PIERRE; BERENS ULRICH; BOUDIER ANDREAS; DOSENBACH OLIVER
权利人:RATIOPHARM GMBH
摘要:The invention relates to a process for the manufacture of an 1,2,4-triazol-1-yl compound of the formula [A], n nor a salt thereof, wherein each of R3 and R4 is hydrogen or lower alkyl, said process comprising reacting a hydrazine compound of the formula [B]n n nwherein R is hydrogen or acyl, R2 is hydrogen or a protecting group, are hydrogen or lower alkyl, and R6 is hydrogen or COOR7, or a salt thereof, with a 1,2,4-triazolyl forming reagent.n n In addition, novel intermediates for the synthesis of the anti-migraine agent Rizatriptan and methods for their synthesis are presented.

专利号:US-9090661-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; MCCAULEY JOHN A; LUDMERER STEVEN W; LIU KUN; VACCA JOSEPH P; WU HAO; HU BIN; SOLL RICHARD; SUN FEI; WANG XINGHAI; YAN MAN; ZHANG CHENGREN; ZHENG MINGWEI; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-3992392-A
优先权日:1973-04-27
标题:Synthesis of indoles from anilines and intermediates therein
发明人：GASSMAN PAUL G
权利人:UNIV OHIO STATE RES FOUND
摘要:Preparing indoles and intermediates therefor by reacting an N-haloaniline with a β-carbonylic hydrocarbon sulfide to form an azasulfonium halide, reacting the azasulfonium halide with a strong base to form a thio-ether indole derivative, and then reducing the thio-ether indole, e.g. with Raney nickel, to form the indole compound. When an acetal or ketal of the β-carbonyl hydrocarbon sulfide is used, the azasulfonium salt is treated with a base, and then with an acid to form the thio-ether indole derivative. When an α-ethyl-β -carbonylic hydrocarbon sulfide is used, the resulting azosulfonium salt reacts with strong base to form a thio-ether indolenine derivative, which on reduction with Raney nickel or complex metal hydrides yields 3-substituted indoles. The aniline may be an aminopyridine to form an aza-indole compound in the process. The azasulfonium salts and thio-ether indole or thio-ether indolenine derivatives can be isolated and recovered from their respective reaction mixtures. The thio-ether-indole and thio-ether indolenine derivatives are useful as intermediates to make the indoles without the thio-ether group. The indoles are known compounds having a wide variety of uses, e.g., in making perfumes, dyes, amino acids, pharmaceuticals, agricultural chemicals and the like.

专利号:US-9023813-B2
优先权日:2011-04-13
标题:Synthesis and use of glycoside derivatives of propofol
发明人：SHULL BRIAN; BALDWIN JOHN; GOPALASWAMY RAMESH; HAROON ZISHAN
权利人:SHULL BRIAN; BALDWIN JOHN; GOPALASWAMY RAMESH; HAROON ZISHAN; NUTEK PHARMA LTD
摘要:The present invention relates to methods and compositions for the synthesis, production, and use of pro-drug propofol analogs. This invention relates to a method for the production of a broad group of glycosylated propofol carbohydrate derivatives.

专利号:US-9777013-B2
优先权日:2013-08-14
标题 :Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents
发明人：NICOLAOU KYRIACOS C; LU MIN; MANDAL DEBASHIS; GANGWAR SANJEEV; CHOWDARI NAIDU S; POUDEL YAM B
权利人:UNIV RICE WILLIAM M; BRISTOL MYERS SQUIBB CO; SCRIPPS RESEARCH INST
摘要:In one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates comprising the compounds of formulae (I) and (II).