CAS: 100367-58-6; 4-Nitronicotinic Acid

该化合物是一种硝基替代衍生物,主要用作有机合成和制药研究的中间体;其位于环环4号位置的硝基化合物组增强了反应性,使其对建造更复杂的环环化化合物具有价值;该化合物在标准条件下具有良好稳定性,便于处理和储存;其结构特征还允许进一步功能化,使医药化学的应用,特别是在生物活性分子的开发中得以应用;本oxylic酸和硝基化合物组的存在在诸如核细胞替代或减少反应等反应中提供了多功能,扩大了其在精细化学合成中的效用.

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7418-65-7 1138011-19-4 66092-63-5

上下游产品

CAS号1678-53-1 3-甲基-4-硝基吡啶 | CAS号1990-90-5 4-氨基-3-甲基吡啶

合成工艺路线路线简述

    📜3-甲基-4-氨基吡啶置于potassium Permanganate,硫酸,三氧化硫,水,双氧水体系中,化学反应生成4-硝基吡啶-3-羧酸
    参考文献:Syntheses And Decarboxylation Of The Isomeric Nitropyridinecarboxylic Acids
    标题:Syntheses And Decarboxylation Of The Isomeric Nitropyridinecarboxylic Acids
    摘要:
    Doi:10.1021/ja01641A016

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    专利信息


    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1007/s007830050039
    摘要:Voltrová S, Prutianov V. Nucleophilic Substitution on 4-Nitro- and 4-Methoxy-3-pyridinecarboxylic Acid-1-oxides. Molecules. 1996 Feb;1(10):207–11. doi: 10.1007/s007830050039.
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