CAS: 871329-61-2; (3-(Pyrrolidin-1-Ylsulfonyl)Phenyl)Boronic Acid

该化合物是一种含有丙烯基磺酰氟替代品的恶性酸衍生物,它增强了其在交叉反应中的效用,特别是铃木-宫的联结. 化合物的黄酸双性会促进与催化剂高效的转金属化,而磺酰组则提高了有机和水媒介的溶性和稳定性. 它的丙烯基会有助于消毒和电子调节,使其在复杂的双子体结构的合成中具有价值. 这种试剂特别适合制药和材料科学应用,其中需要精确的芳香系统功能化. 其定义清晰的再活性和与多种反应条件的兼容性特征强调了其在合成化学中的多功能性.

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    专利信息


    专利号:US-9951062-B2
    优先权日:2012-12-14
    标 题 :Substituted 1 H-pyrrolo [2, 3-b] pyridine and 1 H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
    发明人：VANKAYALAPATI HARIPRASAD; YERRAMREDDY VENKATAKRISHNAREDDY; GANIPISETTY VENU BABU; TALLURI SURESHKUMAR; APPALANENI RAJENDRA P
    权利人:ARRIEN PHARMACEUTICALS LLC
    摘要:Compounds according to Formulas I, IA or IB: n nto pharmaceutically acceptable composition, salts thereof, their synthesis and their use as SIK2 inhibitors including such compounds and methods of using said compounds in the treatment of various diseases and/or disorders such as cancer, stroke, cardiovascular, obesity and type II diabetes.

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    主要参考文献

    参考标题:Chemoselective One-Pot Synthesis Of Functionalized Amino-Azaheterocycles Enabled By Coware
    作者:Thomas A. Clohessy,Alastair Roberts,Eric S. Manas,Vipulkumar K. Patel,Niall A. Anderson,Allan J. B. Watson |发布日期:2017.12.1
    摘要:Functionalized Bicyclic Amino-Azaheterocycles Are Rapidly Accessed In A One-Pot Cross-Coupling/reduction Sequence Enabled By The Use Of Coware. Incompatible Reagents Are Physically Separated In A Single Reaction Vessel To Effect Two Chemoselective Transformations-Suzuki-Miyaura Cross-Coupling And Heteroarene Reduction. The Developed Method Allows Access To Novel Heterocyclic Templates, Including Semisaturated
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