CAS: 87-01-4; 7-(Dimethylamino)-4-Methyl-2H-Chromen-2-One

该化合物是一种荧光可塑性诱导物,因其数量产量和光度高,广泛用作激光染色和荧光探针,其结构上有一个二甲基氨电子施放组和一个甲基替代组,这加强了其蓝绿色光谱范围内的斯托克斯转移和排放强度(~460纳米),这种复合物显示出溶血法行为,使其对极度敏感应用很有价值.它还被用于生物化学标签,光电子材料和PH-敏感氟磷.该化合物的合成多功能和与有机和水系统兼容性进一步扩大了其在研究和工业应用中的用途.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号141-97-9 乙酰乙酸乙酯 | CAS号99-07-0 N,N-二甲基间羟基苯胺 | CAS号99-07-0 N,N-二甲基间羟基苯胺

合成工艺路线路线简述

  • 141-97-9 + 99-07-0 = 87-01-4
    反应条件:1.1 Catalysts: Methanesulfonic Acid,1,1,1-Trifluoro-,Erbium(3+) Salt (3:1) Solvents: Toluene; 8 H,110 °C
    标题:Er(Otf)3-Catalyzed Synthesis Of Fluorescent 7-Aminocoumarins
    作者:Bao,Xiaobo; Et Al
    参考文献:Tetrahedron 日期:2022 卷标:123]

    26093-31-2 = 87-01-4
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 6 H,Rt -> 60 °C; 60 °C -> Rt1.2 Solvents: Water-D2; Rt
    标题:A General Strategy To Enhance Donor-Acceptor Molecules Using Solvent-Excluding Substituents
    作者:Hoelzel,Conner A.; Et Al
    参考文献:Angewandte Chemie 日期:2020 卷标:59(12) 页码:4785-4792]

    16919-18-9 = 87-01-4 + 16919-18-9
    反应条件:1.1 Solvents: Acetonitrile
    标题:Preparation,Photochemistry,And Electronic Structures Of Coumarin Laser Dye Complexes Of Cyclopentadienylruthenium(Ii)
    作者:Koefod,Robert S.; Et Al
    参考文献:Inorganic Chemistry 日期:1989 卷标:28(12) 页码:2285-90]

    141-97-9 + 99-07-0 = 87-01-4
    反应条件:1.1 Catalysts: 2924486-53-1,2924486-54-2; 5 H,Rt -> 90 °C
    标题:Development And Application Of A Supramolecular Bronsted Acid Catalyst Based On The Noria Macrocycle
    作者:Hasselbrink,Carson Lawrence; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2022 卷标:87(23) 页码:16074-16078]

    141-97-9 + 99-07-0 = 87-01-4
    反应条件:1.1 Reagents: Zinc Chloride Solvents: Ethanol; 20 H,Rt -> Reflux; Reflux -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; 2 H,Rt
    标题:Enantioselective Synthesis And Application Of Small And Environmentally Sensitive Fluorescent Amino Acids For Probing Biological Interactions
    作者:Noden,Michael; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2021 卷标:86(17) 页码:11407-11418]

    506-59-2 + 878672-65-2 = 87-01-4
    反应条件:1.1 Reagents: Cesium Carbonate Catalysts: Tris(Dibenzylideneacetone)Dipalladium,X-Phos Solvents: 1,4-Dioxane; 4 H,100 °C
    标题:Azetidine-Containing Heterospirocycles Enhance The Performance Of Fluorophores
    作者:Zhou,Junliang; Et Al
    参考文献:Organic Letters 日期:2020 卷标:22(11) 页码:4413-4417]

    68076-36-8 + 80883-54-1 = 87-01-4
    反应条件:1.1 Reagents: Diisopropylethylamine,O-(7-Azabenzotriazol-1-Yl)-N,N,N′,N′-Tetramethyluronium Hexafluorophosphate Solvents: Dimethylformamide; 1 H,Rt1.2 Solvents: Dimethylformamide; 4 H,Rt
    标题:Bromophycolide A Targets Heme Crystallization In The Human Malaria Parasite Plasmodium Falciparum
    作者:Stout,E. Paige; Et Al
    参考文献:Chemmedchem 日期:2011 卷标:6(9) 页码:1572-1577]

    99-07-0 + 1830-54-2 = 87-01-4
    反应条件:1.1 Reagents: Sulfuric Acid Solvents: Methanol; Overnight,Rt
    标题:Evaluation Of Novel Fluorescence Probes For Conjugation Purposes Using The Traceless Staudinger Ligation
    作者:Wodtke,Robert; Et Al
    参考文献:Dyes And Pigments 日期:2015 卷标:113 页码:263-273
📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid 反应生成 7-二甲氨基-4-甲基香豆素
参考文献:Dey,Journal Of The Chemical Society,1915,Vol. 107,P. 1637
标题:Dey,Journal Of The Chemical Society,1915,Vol. 107,P. 1637

专利信息


专利号:US-12006540-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
发明人：JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J
权利人:UNIV COLUMBIA
摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

专利号:US-5419966-A
优先权日:1991-06-10
标 题 :Solid support for synthesis of 3'-tailed oligonucleotides
发明人：REED MICHAEL W; MEYER JR RICH B; PETRIE CHARLES R; TABONE JOHN C
权利人:MICROPROBE CORP
摘要:A solid support for oligonucleotide synthesis has the structure where CPG represents a controlled pore glass matrix, the wavy line represents a carbon chain covalently linking the NH group with the controlled pore glass matrix, X is 2,2'-dimethoxytrityl or H, and R is alkyl, aryl, arylalkyl, heteroalkyl, or heteroaryl. The dimethoxytrityl group is removed from the solid support by treatment with acid, and the oligonucleotide is built, step-by-step in a conventional synthesizer after attachment of the 3' end of the first oligonucleotide unit to the hydroxyl function connected to the R group.

专利号:US-11959137-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis

专利号:US-2024376536-A1
优先权日:2015-09-28
标题 :Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

专利号:US-2022411860-A1
优先权日:2015-09-28
标题:Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

专利号:US-2023160000-A1
优先权日:2015-09-28
标 题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

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主要参考文献

参考标题:Design And Total Synthesis Of A Fluorescent Phorboxazole A Analog For Cellular Studies
作者:Jiehao Chen,Lu Ying,T. Matthew Hansen,Mary M. Engler,Chi Sing Lee,James J. La Clair,Craig J. Forsyth |发布日期:2006.2
摘要:To Enable Studies To Elucidate The Intracellular Processing And Targeting Of The Potent Cytostatic/apoptotic Anticancer Natural Products Phorboxazoles A And B, A Fluorescent Derivative Has Been Developed. This Involved The Total Syntheses Of The Terminal Alkyne 33-O-Me-45,46-Dehydrobromophorboxazole A (Mdhbpa) And A Terminal Vinyl Iodide Derivative Of The Blue Fluorescent Dye N,N,-Dimethyl-7-Aminocoumarin

合成参考文献

参考DOI号:10.1021/acs.orglett.0c01414
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