CAS: 850544-21-7; Methyl 4-Amino-5-Nitropicolinate

相似化合物

850689-13-3 1000783-10-7 29682-14-2

上下游产品

methanol

📜Ammonium 4-Amino-5-Nitropyridine-2-Carboxylate,甲醇置于硫酸体系中,化学反应 96.0H,以58%的收率获得产物4-氨基-5-硝基-2-吡啶羧酸甲酯
参考文献:Synthesis And Inhibitory Activity Of Benzoic Acid And Pyridine Derivatives On Influenza Neuraminidase
标题:Synthesis And Inhibitory Activity Of Benzoic Acid And Pyridine Derivatives On Influenza Neuraminidase
摘要:Based Upon The Activity And X-Ray Crystallographic Studies Of Tri-Substituted Benzene Derivatives Containing Carboxylic Acid,Acetamido And Guanidine Groups,We Investigated The Effect Of The Fourth Substituent To Fulfill The Fourth Pocket Of Neuraminidase Enzyme. The Groups Selected As Fourth Substituents Were Hydroxymethyl,Hydroxyethyl,Oxime And Amino. These Tetra-Substituted Benzene Derivatives Were Synthesized And Evaluated For Neuraminidase Inhibitory Activity. All These Compounds Were Found To Have Poorer Ic50 Values Than The Tri-Substituted Compounds. Further,Benzene Ring Was Replaced By Pyridine Ring And Di,Tri And Tetra-Substituted Pyridine Derivatives Were Synthesized. The Activity Of The Pyridine Derivatives Was Comparable To Benzene Derivatives. The Fourth Substituent Seems To Disturb The Binding Of The Other Three Substituents,So The Activity Is Reduced As Compared To Trisubstituted Benzene And Pyridine Derivatives. (C) 2005 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmc.2005.01.042