CAS: 837365-04-5; 2,4,5-Trifluoropyridine

该化合物是一种氟化的pyridine衍生物,其特点是在Pyridine环的2,4和5个位置上存在三个氟原子,这种化合物的颜色无色可粉黄,有独特的气味,典型的pyridine衍生物;它是极地,在水中表现出中等溶解性,同时在有机溶剂中更易溶解;三氟甲基组增强了它的活性,能够影响其化学特性,使其在各种应用中有用,包括作为有机合成和制药的建筑块;氟原子的存在往往具有独特的电子特性,可能影响化合物的酸性和基本性;此外,2,4,5-三氟的pyridridine可能表现出与非氟性pyridine衍生物相比不同的再活性模式,使其在合成化学中成为有价值的化合物;在处理这种物质时,应当采取安全防范措施,因为它可能构成健康风险和环境危害.

英文名称2,4,5-Trifluoropyridine
中文名称2,4,5-三氟吡啶
IUPAC名称2,4,5-trifluoropyridine
其它别名2,4,5-Trifluorpyridine; Pyridine, 2,4,5-Trifluoro-
CAS编号837365-04-5
MFCD编号:MFCD04973021
EINECS号:874-839-3
分子式:C5H2F3N
分子量:133.07
产品CID: 1825588
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: SNSQDAAIMIVWAR-UHFFFAOYSA-N
InChI=1S/C5H2F3N/c6-3-1-5(8)9-2-4(3)7/h1-2H…
计算化学: 氢键受体数1.0氢键供体数0.0可旋转键数0.0

相似化合物

700-16-3 76469-41-5 2875-18-5

MSDS等安全信息

GHS象形图
GHS符号GHS02 & GHS07 & GHS05;
注释: Flame & Exclamation mark & Corrosion
危险类别易燃液体类别2
急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀类别1B
警示词Danger(危险)
危险描述H225 |高度易燃液体和蒸气.
H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H314 |造成严重皮肤灼伤和眼损伤.
防范说明P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P405-P501
危险等级3
UN编号1993.0
包装等级Ⅲ

欧盟法规

C&L通报

上下游产品

2,3,4,6-四氟吡啶 2,3,4,6-Tetrafluoropyridine 3512-13-8

合成工艺路线路线简述

259675-77-9 = 837365-04-5
反应条件:1.1 Reagents: Tetrabutylammonium Fluoride1.2 Reagents: Hydrazine1.3 Reagents: Copper Sulfate
标题:Rerouting Nucleophilic Substitution From The 4-Position To The 2- Or 6-Position Of 2,4-Dihalopyridines And 2,4,6-Trihalopyridines: The Solution To A Long-Standing Problem
作者:Schlosser,Manfred; Et Al
参考文献:Organic Letters 日期:2005 卷标:7(1) 页码:127-129]

75-77-4 + 3512-13-8 = 837365-04-5
反应条件:1.1 Reagents: Diisopropylamine,Butyllithium Solvents: Tetrahydrofuran,Hexane; 45 Min,-75 °C2.1 Reagents: Hydrazine Solvents: Tetrahydrofuran; 2 H,0 °C3.1 Reagents: Tetrabutylammonium Fluoride Solvents: Tetrahydrofuran; 2 H,25 °C3.2 Reagents: Copper Sulfate Solvents: Water; 45 Min,Reflux
标题:Removal Of Fluorine From And Introduction Of Fluorine Into Polyhalopyridines: An Exercise In Nucleophilic Hetarenic Substitution
作者:Bobbio,Carla; Et Al
参考文献:Chemistry - A European Journal 日期:2005 卷标:11(6) 页码:1903-1910]

259675-77-9 = 837365-04-5
反应条件:1.1 Reagents: Hydrazine Solvents: Tetrahydrofuran; 2 H,0 °C1.2 Reagents: Tetrabutylammonium Fluoride Solvents: Tetrahydrofuran; 2 H,25 °C1.3 Reagents: Copper Sulfate Solvents: Water; 45 Min,Reflux
标题:Regiochemically Flexible Substitutions Of Di-,Tri-,And Tetrahalopyridines: The Trialkylsilyl Trick
作者:Schlosser,Manfred; Et Al
参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(7) 页码:2494-2502]

259675-77-9 = 837365-04-5
反应条件:1.1 Reagents: Hydrazine Solvents: Tetrahydrofuran; 2 H,0 °C2.1 Reagents: Tetrabutylammonium Fluoride Solvents: Tetrahydrofuran; 2 H,25 °C2.2 Reagents: Copper Sulfate Solvents: Water; 45 Min,Reflux
标题:Removal Of Fluorine From And Introduction Of Fluorine Into Polyhalopyridines: An Exercise In Nucleophilic Hetarenic Substitution
作者:Bobbio,Carla; Et Al
参考文献:Chemistry - A European Journal 日期:2005 卷标:11(6) 页码:1903-1910]

= 837365-04-5
反应条件:1.1 Reagents: Tetrabutylammonium Fluoride Solvents: Tetrahydrofuran; 2 H,25 °C1.2 Reagents: Copper Sulfate Solvents: Water; 45 Min,Reflux
标题:Removal Of Fluorine From And Introduction Of Fluorine Into Polyhalopyridines: An Exercise In Nucleophilic Hetarenic Substitution
作者:Bobbio,Carla; Et Al
参考文献:Chemistry - A European Journal 日期:2005 卷标:11(6) 页码:1903-1910]

75-77-4 + 3512-13-8 = 837365-04-5
反应条件:1.1 Reagents: Diisopropylamine,Butyllithium Solvents: Tetrahydrofuran,Hexane; 45 Min,-75 °C2.1 Reagents: Hydrazine Solvents: Tetrahydrofuran; 2 H,0 °C2.2 Reagents: Tetrabutylammonium Fluoride Solvents: Tetrahydrofuran; 2 H,25 °C2.3 Reagents: Copper Sulfate Solvents: Water; 45 Min,Reflux
标题:Regiochemically Flexible Substitutions Of Di-,Tri-,And Tetrahalopyridines: The Trialkylsilyl Trick
作者:Schlosser,Manfred; Et Al
参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(7) 页码:2494-2502]

1735-84-8 = 837365-04-5
反应条件:1.1 Reagents: Ammonium Formate Catalysts: Palladium Solvents: 1-Octanol; 6 H,25 °C2.1 Reagents: Diisopropylamine,Butyllithium Solvents: Tetrahydrofuran,Hexane; 45 Min,-75 °C3.1 Reagents: Hydrazine Solvents: Tetrahydrofuran; 2 H,0 °C4.1 Reagents: Tetrabutylammonium Fluoride Solvents: Tetrahydrofuran; 2 H,25 °C4.2 Reagents: Copper Sulfate Solvents: Water; 45 Min,Reflux
标题:Removal Of Fluorine From And Introduction Of Fluorine Into Polyhalopyridines: An Exercise In Nucleophilic Hetarenic Substitution
作者:Bobbio,Carla; Et Al
参考文献:Chemistry - A European Journal 日期:2005 卷标:11(6) 页码:1903-1910

2,3,4,6-四氟吡啶置于正丁基锂,四丁基氟化铵,Copper(II) Sulfate,二异丙胺,肼体系中,用四氢呋喃,正己烷作为反应溶剂,化学反应 5.5H,反应生成 2,4,5-三氟吡啶
参考文献:从聚卤代吡啶中除去氟并将氟引入到聚卤代吡啶中:亲核性戊烯取代反应.
标题:从聚卤代吡啶中除去氟并将氟引入到聚卤代吡啶中:亲核性戊烯取代反应.
摘要:从六个工业上可获得的氟化吡啶开始,开发了一种方便的途径来获取所有三个四氟吡啶(2-4),所有六个三氟吡啶(5-10)和五个非商业性二氟吡啶(11-14和16).用于从多氟吡啶中选择性除去氟的方法是通过金属或复合氢化物进行还原,并用肼进行位点选择性置换,然后进行脱氢-脱重氮或脱氢氯化-脱重氮.为了引入额外的氟原子,在进行氯/氟置换过程之前,将合适的前体金属化和氯化.
DOI:10.1002/chem.200400837