CAS: 81840-15-5; 6-(4-(3,4-Dimethoxybenzoyl)Piperazin-1-yl)-3,4-Dihydroquinolin-2(1H)-One

该化合物是一种合成化合物,主要因其心血管保护特性而得到承认,特别是在心脏衰竭治疗方面,它是一种积极的不孕剂,可以提高心脏肌肉的耐受性,而不会大量增加氧气需求.Vesnarinone被归类为一种丙烯酸衍生物,并展示了一种独特的行动机制,它涉及抑制磷酸丁酯,导致心脏组织中循环氨酸氨酯含量增加.这导致心肌功能的改善和心脏衰竭症状的减少.该化合物还具有血管衰竭效应,有助于其治疗效果.在药理学方面,Vesnarinone在肝脏中被代谢,其代谢物可以有不同的生物活动.虽然它在临床环境中表现出了希望,但使用vesnarinone由于对副作用和替代疗法的提供情况的关切而受到限制.

结构式图片

物理性质

MSDS等安全信息

上下游产品

CAS号22246-13-5 6-氨基-3,4-二氢-2(1... | CAS号81840-14-4 N,N-(di-β-bromo... | CAS号87154-95-8 6-Piperazino-1,... | CAS号86813-31-2 6-(1-piperaziny... | CAS号3535-37-3 3,4-二甲氧基苯甲酰氯 | CAS号43204-63-3 双(2-溴乙基)胺氢溴酸盐 | CAS号3943-77-9 3,4-二甲氧基苯甲酸乙酯 | CAS号93-07-2 藜芦酸 | CAS号87154-95-8 6-Piperazino-1,...

合成工艺路线路线简述

  • 22246-13-5 + 821-48-7 + 146849-18-5 = 81840-15-5
    反应条件:1.1 Catalysts: Potassium Carbonate Solvents: Ethanol,Water
    标题:Synthesis Of Vesnarinone Via Active Esters
    参考文献:China]

    = 81840-15-5 [标题:Reaction Conditions
    标题:Carbostyril Derivatives Used As Cardiotonic Agents And Medicines Containing Them
    参考文献:Belgium]

    = 81840-15-5
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 16 H,10 Bar,70 °C2.1 Reagents: Potassium Carbonate Catalysts: Potassium Tetrachloropalladate (Supported On Zif-8),Bis[2-(Diphenylphosphino)Phenyl] Ether Solvents: 1,4-Dioxane; 18 H,10 Bar,120 °C
    标题:Concise Synthesis Of Vesnarinone And Its Analogues By Using Pd-Catalyzed C-N Bond-Forming Reactions
    作者:See,Yi Yang; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2014 卷标:2014(33) 页码:7405-7412]

    22246-13-5 + 821-48-7 = 81840-15-5
    反应条件:1.1 Reagents: Sodium Carbonate Solvents: Ethanol; 8 H,Reflux; 8 H,Reflux2.1 Reagents: Triethylamine Solvents: Dichloromethane; 0 - 5 °C; 4 H,Rt
    标题:Synthesis Of Vesnarinone
    作者:Zhang,Mengdi; Et Al
    参考文献:Jingxi Huagong Zhongjianti 日期:2011 卷标:41(1) 页码:39-41]

    4746-97-8 + 79-06-1 = 81840-15-5
    反应条件:1.1 Reagents: Pyrrolidine Catalysts: P-Toluenesulfonic Acid Solvents: Toluene; 4 H,Reflux; Reflux -> Rt1.2 Solvents: 1,4-Dioxane; 12 H,Reflux; Reflux -> Rt1.3 Catalysts: Indium Trichloride Solvents: Methanol,Water; 1 H,Reflux2.1 Reagents: Dabco Catalysts: Acetic Acid,(Oc-6-42)-Bis[[2,3-Butanedione 2,3-Di(Oximato-Kn)](1-)]Chloro(N,N-Dimethyl-4-Pyr...,Iridium(1+),[4,4′-Bis(1,1-Dimethylethyl)-2,2′-Bipyridine-Kn1,Kn1′]Bis[2-(2-Pyri... Solvents: Acetonitrile; 24 H,Rt
    标题:A Photochemical Dehydrogenative Strategy For Aniline Synthesis
    作者:U. Dighe,Shashikant; Et Al
    参考文献:Nature (London 日期:2020 卷标:584(7819) 页码:75-81]

    3535-37-3 + 117392-78-6 = 81840-15-5 [标题:Reaction Conditions
    标题:Carbostyril Derivatives Used As Cardiotonic Agents And Medicines Containing Them
    参考文献:Belgium]

    81840-03-1 = 81840-15-5 [标题:Reaction Conditions
    标题:Carbostyril Derivatives Used As Cardiotonic Agents And Medicines Containing Them
    参考文献:Belgium]

    625-36-5 = 81840-15-5
    反应条件:1.1 Solvents: Acetone; 0.5 H,0 - 5 °C; 2 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; 10 Min2.1 Reagents: Tin Tetrachloride; 4 H,Rt -> 160 °C2.2 Reagents: Water; Cooled3.1 Reagents: Sulfuric Acid,Nitric Acid Solvents: Water; < 10 °C; 3 H,Rt4.1 Reagents: Hydrochloric Acid,Stannous Chloride Solvents: Water; 55 - 60 °C; 4 H4.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 12,Cooled5.1 Reagents: Sodium Carbonate Solvents: Ethanol; 8 H,Reflux; 8 H,Reflux6.1 Reagents: Triethylamine Solvents: Dichloromethane; 0 - 5 °C; 4 H,Rt
    标题:Synthesis Of Vesnarinone
    作者:Zhang,Mengdi; Et Al
    参考文献:Jingxi Huagong Zhongjianti 日期:2011 卷标:41(1) 页码:39-41]

    6628-86-0 = 81840-15-5 [标题:Reaction Conditions
    标题:Carbostyril Derivatives Used As Cardiotonic Agents And Medicines Containing Them
    参考文献:Belgium]

    81839-52-3 + 1260803-14-2 = 81840-15-5
    反应条件:1.1 Reagents: Dabco Catalysts: Acetic Acid,(Oc-6-42)-Bis[[2,3-Butanedione 2,3-Di(Oximato-Kn)](1-)]Chloro(N,N-Dimethyl-4-Pyr...,Iridium(1+),[4,4′-Bis(1,1-Dimethylethyl)-2,2′-Bipyridine-Kn1,Kn1′]Bis[2-(2-Pyri... Solvents: Acetonitrile; 24 H,Rt
    标题:A Photochemical Dehydrogenative Strategy For Aniline Synthesis
    作者:U. Dighe,Shashikant; Et Al
    参考文献:Nature (London 日期:2020 卷标:584(7819) 页码:75-81]

    87154-95-8 + 2859-78-1 = 81840-15-5
    反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Potassium Tetrachloropalladate (Supported On Zif-8),Bis[2-(Diphenylphosphino)Phenyl] Ether Solvents: 1,4-Dioxane; 18 H,10 Bar,120 °C
    标题:Concise Synthesis Of Vesnarinone And Its Analogues By Using Pd-Catalyzed C-N Bond-Forming Reactions
    作者:See,Yi Yang; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2014 卷标:2014(33) 页码:7405-7412]

    3535-37-3 = 81840-15-5
    反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; 0 - 5 °C; 4 H,Rt
    标题:Synthesis Of Vesnarinone
    作者:Zhang,Mengdi; Et Al
    参考文献:Jingxi Huagong Zhongjianti 日期:2011 卷标:41(1) 页码:39-41]

    = 81840-15-5 [标题:Reaction Conditions
    标题:Carbostyril Derivatives Used As Cardiotonic Agents And Medicines Containing Them
    参考文献:Belgium]

    22246-16-8 = 81840-15-5
    反应条件:1.1 Reagents: Hydrochloric Acid,Stannous Chloride Solvents: Water; 55 - 60 °C; 4 H1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 12,Cooled2.1 Reagents: Sodium Carbonate Solvents: Ethanol; 8 H,Reflux; 8 H,Reflux3.1 Reagents: Triethylamine Solvents: Dichloromethane; 0 - 5 °C; 4 H,Rt
    标题:Synthesis Of Vesnarinone
    作者:Zhang,Mengdi; Et Al
    参考文献:Jingxi Huagong Zhongjianti 日期:2011 卷标:41(1) 页码:39-41]

    3279-90-1 = 81840-15-5
    反应条件:1.1 Reagents: Potassium Carbonate,Lithium Bis(Trimethylsilyl)Amide Catalysts: Tris(Dibenzylideneacetone)Dipalladium,2′-(Dicyclohexylphosphino)-N,N-Dimethyl[1,1′-Biphenyl]-2-Amine Solvents: Toluene,Tetrahydrofuran; 6 Bar,Rt -> 65 °C; 24 H,65 °C; 65 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; 5 Min,Rt1.3 Reagents: Sodium Bicarbonate Solvents: Water; Basified,Rt2.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; 16 H,10 Bar,70 °C3.1 Reagents: Potassium Carbonate Catalysts: Potassium Tetrachloropalladate (Supported On Zif-8),Bis[2-(Diphenylphosphino)Phenyl] Ether Solvents: 1,4-Dioxane; 18 H,10 Bar,120 °C
    标题:Concise Synthesis Of Vesnarinone And Its Analogues By Using Pd-Catalyzed C-N Bond-Forming Reactions
    作者:See,Yi Yang; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2014 卷标:2014(33) 页码:7405-7412]

    = 81840-15-5 [标题:Reaction Conditions
    标题:Carbostyril Derivatives Used As Cardiotonic Agents And Medicines Containing Them
    参考文献:Belgium]

    141-82-2 = 81840-15-5 [标题:Reaction Conditions
    标题:Carbostyril Derivatives Used As Cardiotonic Agents And Medicines Containing Them
    参考文献:Belgium]

    553-03-7 = 81840-15-5
    反应条件:1.1 Reagents: Sulfuric Acid,Nitric Acid Solvents: Water; < 10 °C; 3 H,Rt2.1 Reagents: Hydrochloric Acid,Stannous Chloride Solvents: Water; 55 - 60 °C; 4 H2.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 12,Cooled3.1 Reagents: Sodium Carbonate Solvents: Ethanol; 8 H,Reflux; 8 H,Reflux4.1 Reagents: Triethylamine Solvents: Dichloromethane; 0 - 5 °C; 4 H,Rt
    标题:Synthesis Of Vesnarinone
    作者:Zhang,Mengdi; Et Al
    参考文献:Jingxi Huagong Zhongjianti 日期:2011 卷标:41(1) 页码:39-41]

    3460-04-6 = 81840-15-5
    反应条件:1.1 Reagents: Tin Tetrachloride; 4 H,Rt -> 160 °C1.2 Reagents: Water; Cooled2.1 Reagents: Sulfuric Acid,Nitric Acid Solvents: Water; < 10 °C; 3 H,Rt3.1 Reagents: Hydrochloric Acid,Stannous Chloride Solvents: Water; 55 - 60 °C; 4 H3.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 12,Cooled4.1 Reagents: Sodium Carbonate Solvents: Ethanol; 8 H,Reflux; 8 H,Reflux5.1 Reagents: Triethylamine Solvents: Dichloromethane; 0 - 5 °C; 4 H,Rt
    标题:Synthesis Of Vesnarinone
    作者:Zhang,Mengdi; Et Al
    参考文献:Jingxi Huagong Zhongjianti 日期:2011 卷标:41(1) 页码:39-41
📜在 Copper Diacetate,硼酸,Palladium Diacetate,特戊酸钠,2-二环己基磷-2,4,6-三异丙基联苯体系中,用 二氯甲烷,丙酮,乙腈 作为反应溶剂,化学反应 45.0H,反应生成 维司力农
参考文献:钯催化简单的芳烃通过噻吩苯砜化的位点选择性硼化†
标题:钯催化简单的芳烃通过噻吩苯砜化的位点选择性硼化†
摘要:简单的芳烃的位点选择性硼化通过亲电子的thththrenation / Pd催化的硼化序列实现.实现这种操作上简单的过程的关键是使用pd催化,该催化可以耐受在thththrenation步骤中使用的溶剂和酸性条件.该方案具有温和的条件,宽泛的官能团耐受性和简单的操作方法,适用于各种药物和复杂的生物活性分子的后期功能化.
DOI:10.1002/cjoc.202000212

海关参考信息

专利信息


专利号:US-2003049619-A1
优先权日:2001-03-21
标题 :Methods for the synthesis of polynucleotides and combinatorial libraries of polynucleotides
发明人：DELAGRAVE SIMON; MARRS BARRY
摘要:Methods for the synthesis of polynucleotides and derivatives thereof are provided. Methods for the preparation of combinatorial libraries of polynucleotides are also provided. In addition, methods for the preparation and identification of polynucleotides having a predetermined property are provided.

专利号:US-2021171994-A1
优先权日:2015-01-22
标题 :Gene Synthesis by Self-Assembly of Small Oligonucleotide Building Blocks
发明人：PEDERSEN MORTEN LORENTZ; Pedersen Gitte Laurette; KANIGAN TANYA SHARLENE
权利人:MLP HOLDING APS
摘要:The invention provides a process for synthesizing genes and other long double stranded polynucleotides by assembling very short oligonucleotides into partly double stranded polynucleotides, and then connecting these partly double stranded polynucleotide subassemblies with linkers comprised of very short oligonucleotides. In one embodiment, the correct order of the polynucleotide subassemblies is coded in overhangs present at each end of the partly double stranded polynucleotide subassemblies. Linkers having a sequence complimentary to the combined overhangs connect adjacent subassemblies, which are then ligated together. In one preferred embodiment the oligos are six bases long, for which there are only 4096 different possible sequence permutations. A complete library of oligos of this size and scale can be cost-effectively synthesized and quality controlled, avoiding the typical errors and yield issues associated with phosphoramidite synthesis of longer oligos. Furthermore, the limited oligo library size supports development of a laboratory-scale gene synthesis machine.

专利号:US-5869644-A
优先权日:1992-04-15
标题:Synthesis of diverse and useful collections of oligonucleotidies
发明人：SHORTLE DAVID R; SONDEK JOHN
权利人:UNIV JOHNS HOPKINS
摘要:A new technique for generating mixtures of oligonucleotides in a single automated synthesis is taught. The method can be used to prepare mixed oligonucleotides ideally suited for creation of useful mixtures of oligo- or polypeptides or proteins. Additionally, the technique enables insertion and/or substitution and/or deletion of a nucleotide sequence at one or more sites. For protein mutagenesis, a trinucleotide can be inserted or substituted at codon boundaries. The invented technique makes possible the encoding of all possible single amino acid insertions, or any desired mixture of substitutions and insertions.

专利号:US-2025283053-A1
优先权日:2022-04-20
标 题 :Enhanced cell-free bacteriophage synthesis by genetic modulation of bacterial transcription/translation machinery (txtl) machinery
发明人：BROOKS RANI
权利人:THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
摘要:The present disclosure relates to compositions including or obtained from genetically modified bacterial host cells (e.g., E. coli ) and methods for using the same for cell-free bacteriophage synthesis (CFBS). In particular, the present technology relates to genetically modified E. coli that overexpress one or more of translation initiation factor IF-3 (infC), OxyS and CyaR and/or repress RecC subunit exonuclease RecBCD, and methods for using the same to obtain improved CFBS yields.

专利号:EP-0638089-B2
优先权日:1992-04-15
标题:Synthesis of diverse and useful collections of oligonucleotides
发明人：SHORTLE DAVID R; SONDEK JOHN
权利人:UNIV JOHNS HOPKINS
摘要:A new technique for generating mixtures of oligonucleotides in a single automated synthesis is taught. The method can be used to prepare mixed oligonucleotides ideally suited for creation of useful mixtures of oligo- or polypeptides or proteins. Additionally, the technique enables insertion and/or substitution and/or deletion of a nucleotide sequence at one or more sites. For protein mutagenesis, a trinucleotide can be inserted or substituted at codon boundaries. The invented technique makes possible the encoding of all possible single amino acid insertions, or any desired mixture of substitutions and insertions.

专利号:US-2003157592-A1
优先权日:1999-12-16
标题:Moss genes from physcomitrella patens encoding proteins involved in the synthesis of tocopherols and carotenoids
发明人：LERCHL JENS; RENZ ANDREAS; EHRHARDT THOMAS; REINDL ANDREAS; CIRPUS PETRA; BISCHOFF FRIEDRICH; FRANK MARKUS; FREUND ANNETTE; DUWENIG ELKE; SCHMIDT RALF-MICHAEL; RESKI RALF; BADUR RALF
摘要:Isolated nucleic acid molecules, designated TCMRP nucleic acid molecules, which encode novel TCMRPs from e.g. Phycomitrella patens are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TCMRP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated TCMRPs, mutated TCMRPs, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from transformed cells, organisms or plants based on genetic engineering of TCMRP genes in these organisms.

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主要参考文献


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合成参考文献


摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
参考文献:10.2165/00003495-199651030-00001
摘要:Bonarjee VV, Dickstein K. Novel drugs and current therapeutic approaches in the treatment of heart failure. Drugs. 1996 Mar;51(3):347–58. doi: 10.2165/00003495-199651030-00001.
参考文献:10.1007/s001340050913
摘要:Heinz G, Geppert A, Delle Karth G, Reinelt P, Gschwandtner ME, Neunteufl T, Zauner C, Frossard M, Siostrzonek P. IV milrinone for cardiac output increase and maintenance: comparison in nonhyperdynamic SIRS/sepsis and congestive heart failure. Intensive Care Med. 1999 Jun;25(6):620–4. doi: 10.1007/s001340050913.
参考文献:10.1007/s11886-002-0051-3
摘要:Lisman KA, Stetson SJ, Koerner MM, Farmer JA, Torre-Amione G. The role of inflammation in the pathogenesis of heart failure. Curr Cardiol Rep. 2002 May;4(3):200–5. doi: 10.1007/s11886-002-0051-3.
参考文献:10.1016/s0167-5273(01)00447-8
摘要:van Veldhuisen DJ, Poole-Wilson PA. The underreporting of results and possible mechanisms of ‘negative’ drug trials in patients with chronic heart failure. International Journal of Cardiology. 2001 Aug;80(1):19–27. doi: 10.1016/s0167-5273(01)00447-8.
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