CAS: 78056-28-7; 3-Methyladamantan-1-Amine

相似化合物

33103-93-4 15210-60-3 768-94-5

上下游产品

CAS号778-09-6 N-乙酰基去甲基美金刚 | CAS号702-77-2 1-溴-3-甲基金刚烷 | CAS号702-81-8 3-甲基-1-金刚烷醇 | CAS号768-91-2 1-甲基金刚烷

📜N-乙酰基去甲基美金刚置于sodium Hydroxide体系中,用 二乙二醇 作为反应溶剂,化学反应生成 3-甲基金刚烷-1-胺
参考文献:Structure-Anti-Parkinson Activity Relationships In The Aminoadamantanes. Influence Of Bridgehead Substitution
标题:Structure-Anti-Parkinson Activity Relationships In The Aminoadamantanes. Influence Of Bridgehead Substitution
摘要:A Limited Series Of Bridgehead Alkyl-,Dialkyl-,And Trialkyl-Substituted Amantadines Was Synthesized And Tested For Potential Anti-Parkinson Activity As Dopamine (Da) Agonists. The Compounds Were Evaluated Using A Battery Of Three Murine Bioassays,Including Stimulation Of Locomotor Activity,Induction Of Circling In Animals With Unilateral Striatal Lesions,And Reversal Of Reserpine/alpha-Methyltyrosine Induced Akinesia. Apparent Mechanistic Differences Were Seen Between The Methyl-Substituted Series And The Ethyl-Substituted Series. While Activities In Both Series Increase With Increasing Liphophilicity,The Methyl Series (1B--D),As Well As Amantadine Itself (1A),Exhibit Only Indirect Da Agonist Activity,As Evidenced By Ipsilateral Rotation In The Circling Model And No Significant Difference From Control In Reversal Of Akinesia. The Ethyl Series (1E,F) Exhibits Weak But Reproducible Direct Da Agonist Activity,As Shown By Contralateral Rotation In The Circling Assay For 1E And Reversal Of Akinesia By 1E And 1F. The 3-N-Propyl Derivative (1G) Was Devoid Of Any Da Agonist Activity.
DOI:10.1021/jm00343A010