CAS: 7361-61-7; Xylazine

上下游产品

2,6-dimethylaniline 2,6-dimethylphenylisothi°Cyanate propan-1-ol-3-amine N-(2,6-dimethylphenyl)acetamideH-[1,3]thiazin-2-yl)-(2,6-dimethyl-phenyl)-carbamic acid ethyl ester(5,6-dihydro-4H-[1,3]thiazin-2-yl)-(2,6-dimethyl-phenyl)-carbamic acid ethyl ester Z)-2,6-dimethyl-phenylimino)-[1,3]thiazinane-3-carboxylic acid ethyl ester2-((Z)-2,6-dimethyl-phenylimino)-[1,3]thiazinane-3-carboxylic acid ethyl ester N-(5,6-dihydro-4H-[1,3]thiazin-2-yl)-N-(2,6-dimethyl-phenyl)-4-methoxy-benzamideN-(5,6-dihydro-4H-[1,3]thiazin-2-yl)-N-(2,6-dimethyl-phenyl)-4-methoxy-benzamide N-(5,6-dihydro-4H-[1,3]thiazin-2-yl)-N-(2,6-dimethyl-phenyl)-2-methyl-benzamideN-(5,6-dihydro-4H-[1,3]thiazin-2-yl)-N-(2,6-dimethyl-phenyl)-2-methyl-benzamide

📜2,6-二甲基苯胺置于盐酸,Sodium Hydride体系中,用 四氢呋喃,甲基叔丁基醚,水 作为反应溶剂,化学反应 7.0H,反应生成 赛拉嗪
参考文献:一种盐酸二甲苯胺噻嗪的制备方法
标题:一种盐酸二甲苯胺噻嗪的制备方法
摘要:本发明公开了一种盐酸二甲苯胺噻嗪的制备方法,按照先后顺序包括以下步骤:将化合物1经过乙酰化得到化合物2,在反应的过程中加入乙酸酐等;将上述步骤得到的化合物2先与氢化钠反应,再与二硫化碳反应反应生成化合物3;化合物3再与化合物反应,得到化合物5;化合物5在盐酸的作用下环化得到化合物6;化合物6成盐得到盐酸二甲苯胺噻嗪.本专利方法提高了操作的便利性,收率以及产品纯度得到极大提高,总体成本大大降低.

专利信息

专利号:US-12383499-B2
优先权日:2018-01-01
标题:Scale up synthesis of silicasome nanocarriers
发明人：NEL ANDRE E; MENG HUAN; LIU XIANGSHENG
权利人:UNIV CALIFORNIA
摘要:In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg/batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).

专利号:US-7709442-B2
优先权日:2003-09-19
标 题 :In vivo synthesis of connective tissues
发明人：MAO JEREMY JIAN
权利人:UNIV COLUMBIA
摘要:The in vivo synthesis of connective tissue by fibroblast or fibroblast precursor cells ensconced within a biocompatible scaffold is disclosed. The cells are preferably present in a biocompatible scaffold such as gelatin and placed between two other biocompatible scaffolds such as collagen sponges soaked with a collagenic amount of a member of the TGF-β family of proteins. This composition is then implanted in a host to produce cranial sutures, periodontal ligament or other fibrous tissue structures in vivo.

专利号:US-9828452-B1
优先权日:2004-11-11
标 题 :Process for the synthesis of poly (vinyl alcohol) and/or poly (vinyl acetate) with spherical morphology and shell-and-nucleus structure and its use in vascular embolization
发明人：COSTA DA SILVA PINTO JOSÉ CARLOS; Niemeyer Limeira Mariana Araújo; SILVA FABRICIO MACHADO; MELO PRIAMO ALBUQUERQUE; DE SOUZA MÃ?RCIO NELE; Lopez Galdêncio Espinosa
权利人:COSTA DA SILVA PINTO JOSÉ CARLOS; Niemeyer Limeira Mariana Araújo; SILVA FABRICIO MACHADO; MELO PRIAMO ALBUQUERQUE; DE SOUZA MÃ?RCIO NELE; Lopez Galdêncio Espinosa; INST ALBERTO LUIZ COIMBRA DE PÓS-GRADUAÇÃO E PESQUISA DE ENGENHARIA—COPPE; FIRST LINE IND E COMMERCIA S/A
摘要:The present invention describes a process for the synthesis of spherical particles of polyvinyl alcohol—PVA and/or polyvinyl acetate—PVAc with shell nucleus structure from total or partial hydrolysis in a caustic aqueous medium with obtaining particulates of PVA/PVAc with controlled spherical morphology, to be used in vascular embolization.

专利号:US-7202226-B2
优先权日:2000-10-23
标 题 :Augmentation of wound healing by elF-4E mRNA and EGF mRNA
发明人：MURRAY MARY THERESA; DULCHAVSKY SCOTT ALEXANDER
权利人:DETROIT R & D
摘要:There is provided a method of augmenting transient protein synthesis in a cell by delivering to the cell mRNA functionally related to protein production. Also provided is a method of augmenting transient protein synthesis in cells by increasing protein synthesis of growth factors from endogenous cellular mRNA and exogenous mRNA delivered to the cells. A treatment for transiently increasing protein production in cells, said treatment comprising mRNA functionally related to protein production is also provided. There is provided a method of augmenting wound healing by delivering mRNA functionally related to wound healing. Further provided is a therapeutic for transiently increasing protein synthesis in cells, said therapeutic comprising mRNA related to protein production.

专利号:US-6133242-A
优先权日:1993-10-15
标题 :Inhibition of extracellular matrix synthesis by antisense compounds directed to nuclear proto-oncogenes
发明人：ZALEWSKI ANDREW; SHI YI
权利人:THOMAS JEFFERSON UNIVERISITY
摘要:A method and compounds are provided for inhibiting the synthesis of extracellular matrix proteins. Compounds of the invention comprise antisense oligonucleotides specific for nuclear proto-oncogenes. Preferably, antisense compounds of the invention are selected from the group consisting of c-myc and c-myb and are locally administered. The invention finds use in the treatment of a variety of disorders, including sclerotic disorders and restenosis, associated with the inappropriate synthesis of extracellular matrix proteins, particularly collagen.

专利号:EP-0799313-A2
优先权日:1994-12-13
标 题 :Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses
发明人：BEIGELMAN LEONID; STINCHCOMB DANIEL T; JARVIS THALE; DRAPER KENNETH; PAVCO PAMELA; MCSWIGGEN JAMES; GUSTOFSON JOHN; USMAN NASSIM; WINCOTT FRANCINE; MATULIC-ADAMIC JASENKA; KARPEISKY ALEXANDER; THOMPSON JAMES D; MODAK ANIL; BURGIN ALEX
权利人:RIBOZYME PHARM INC
摘要:An enzymatic nucleic acid molecule which cleaves RNA associated with development or maintenance of an arthritic condition, induction of graft tolerance or reversal of an immune response. In particular, the ribozyme sequences are directed to an mRNA encoding B7-1, B7-2, B7-3, CD40 and/or stromelysin. Also provided are ribozymes where the uracil in positions 4 and/or 7 are substituted, as well as methods for the synthesis of 2'-alkylnucleotides, 2'-O-alkylthioalkyl, or 2'-alkylthioalkylnucleotides. The application further describes a method for diprotection of RNA with aqueous ethylamine, a method for synthesis of a basic ribonucleoside mimetics, and transcription units comprising an RNA polymerase II promoter, a U6 small nuclear promoter, or an adenovirus VA1 promoter system.