CAS: 69045-78-9; 2-Chloro-5-(Trichloromethyl)Pyridine

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CAS号3510-66-5 2-溴-5-甲基吡啶 | CAS号52334-81-3 2-氯-5-三氟甲基吡啶 | CAS号70258-18-3 2-氯-5-氯甲基吡啶 | CAS号33252-63-0 2-羟基-5-三氟甲基吡啶 | CAS号4214-73-7 2-氨基-5-氰基吡啶 | CAS号79456-26-1 2-氨基-3-氯-5-三氟甲基吡啶 | CAS号89570-85-4 2-肼基-5-三氟甲基砒啶 | CAS号69045-83-6 2,3-二氯-5-三氯甲基吡啶 | CAS号5326-23-8 6-氯烟酸 | CAS号76041-72-0 2-巯基-5-(三氟甲基)吡啶 | CAS号52334-81-3 2-氯-5-三氟甲基吡啶 | CAS号69045-82-5 2-氟-5-三氟甲基吡啶 | CAS号71701-84-3 Pyridine, 2-chl...

3-甲基吡啶置于四氯化碳,氯体系中,化学反应生成 2-氯-5-三氯甲基吡啶
参考文献:一种高纯度的2-氯-5-三氟甲基吡啶的生产方法
标题:一种高纯度的2-氯-5-三氟甲基吡啶的生产方法
摘要:本发明提供一种高纯度的2‑氯‑5‑三氟甲基吡啶的生产方法,包括以下步骤:在二氧化硅‑三氧化二铝‑三氧化二铬催化剂的作用下,以丙烯醛和丙醛为原料,经气化与氨气反应反应生成3‑甲基吡啶;将3‑甲基吡啶和四氯化碳共同气化后,在氯气氛围下反应得到2‑氯‑5‑三氯甲基吡啶,再氟取代,得到2‑氯‑5‑三氟甲基吡啶粗品;将2‑氯‑5‑三氟甲基吡啶粗品加热融化后,置于低温恒温装置中进行制冷和循环,经冷却结晶,分离得到再结晶,将再结晶发汗,重复循环融化再结晶和发汗过程,得到高纯度的2‑氯‑5‑三氟甲基吡啶.本发明采用3‑甲基吡啶作为原料,并对2‑氯‑5‑三氟甲基吡啶进行熔融再结晶提纯,使制备的产品纯度高,产量稳定.

专利信息

专利号:WO-2022099693-A1
优先权日:2020-11-16
标题 :Method for improving effect of fluorination reaction in synthesis of 2-chloro-5-trifluoromethyl pyridine, and matching system
发明人：ZHA ZHIXIONG; LI HAO
权利人:SHANXIAN XINRUN CHEMICAL CO LTD
摘要:The present invention relates to the technical field of chemical synthesis, and particularly, a method for improving effect of fluorination reaction in the synthesis of 2-chloro-5-trifluoromethyl pyridine, and a matching system. The method comprises the following steps: preparing 2-chloro-5-trichloromethyl pyridine, and adding to an efficient reaction system after superfine crushing; adding an appropriate amount of iodine pentafluoride, mercury fluoride and a catalyst into the efficient reaction system; controlling the temperature and time, and carrying out a fluorination reaction on materials in the high-pressure, sealed, efficient reaction system to obtain a crude solution containing 2-chloro-5-trifluoromethyl pyridine; purifying the above crude solution to obtain 2-chloro-5-trifluoromethyl pyridine. In the present method, a fluorination reaction is carried out in a high-pressure sealed environment, such that the efficiency and effect of the fluorination reaction are effectively improved. By means of the system in the present invention, the material entering the system may be quickly superfine crushed before the reaction, so as to improve the reaction sufficiency in the subsequent reaction process.

专利号:US-4658031-A
优先权日:1982-10-07
标 题:Synthesis of 2-substituted-5-methyl-pyridines and intermediates therefor
发明人：HARTMANN LUDWIG A; STEPHEN JOHN F
权利人:ICI AMERICA INC
摘要:A process for the synthesis of compounds which are known intermediates for the pyridyloxyphenoxy herbicies as well as intermediates used in the process. Propionaldehyde and an acrylic compound, two readily available starting materials, are reacted to form a 2-formylpentanoic compound which is cyclized to a dihydro pyridone which is then oxidized to the 2-hydroxy pyridine. The hydroxypyridine may be halogenated to a 2-halopyridine.

专利号:US-4584380-A
优先权日:1982-10-07
标 题:Synthesis of 2-substituted-5-methyl-pyridines and intermediates therefor
发明人：HARTMANN LUDWIG A; STEPHEN JOHN F
权利人:ICI AMERICA INC
摘要:A process for the synthesis of compounds which are known intermediates for the pyridyloxyphenoxy herbicides as well as intermediates used in the process. Propionaldehyde and an acrylic compound, two readily available starting materials, are reacted to form a 2-formylpentanoic compound which is cyclized to a dihydro pyridone which is then oxidized to the 2-hydroxy pyridine. The hydroxypyridine may be halogenated to a 2-halopyridine.

专利号:US-4473696-A
优先权日:1982-10-07
标题:Synthesis of 2-substituted-5-methyl-pyridines
发明人：HARTMANN LUDWIG A; STEPHEN JOHN F
权利人:ICI AMERICA INC
摘要:A process for the synthesis of compounds which are known intermediates for the pyridyloxyphenoxy herbicides as well as intermediates used in the process. Propionaldehyde and an acrylic compound, two readily available starting materials, are reacted to form a 2-formylpentanoic compound which is cyclized to a dihydro pyridone which is then oxidized to the 2-hydroxy pyridine. The hydroxypyridine may be halogenated to a 2-halopyridine.

专利号:US-4687854-A
优先权日:1982-10-07
标 题 :Bispiperidone precursor of 2-substituted-5-methyl-pyridines
发明人：HARTMANN LUDWIG A; STEPHEN JOHN F
权利人:ICI AMERICA INC
摘要:A process for the synthesis of compounds which are known intermediates for the pyridyloxyphenoxy herbicides as well as intermediates used in the process. Propionaldehyde and an acrylic compound, two radily available starting materials, are reacted to form a 2-formylpentanoic compound which is cyclized to a dihydro pyridone which is then oxidized to the 2-hydroxy pyridine. The hydroxypyridine may be halogenated to a 2-halopyridine.

专利号:US-4612377-A
优先权日:1983-03-30
标题:Preparation of 2-chloro-5-methylpyridine
发明人：OSBORNE ROBERT; BAILEY KEVIN D
权利人:ICI PLC
摘要:A 2-oxo-5-methyl-5,6-dihalopiperidine is contacted in a high boiling solvent, preferably trichlorobenzene, with a stoichiometric excess, up to 70 mole % excess, of a chlorinating agent, preferably phosphorus oxychloride or phosgene, at an elevated temperature between 80 DEG and 130 DEG C. The solution of 2-chloro-5-methylpyridine so obtained may be used directly for further chlorination to form 2-chloro-5-trichloromethylpyridine with, for example, chlorine gas in the presence of a free radical initiator. This chemical intermediate is useful in the synthesis of certain herbicidal compounds.