CAS: 6406-74-2; 4-((Dimethylamino)Methyl)Aniline

该化合物是一种有机化合物,其特征是其有矿功能组和二甲基氨基替代成分.该化合物的特征是带有氨基环的苯环,其位置与甲基胺组相对,其位置是氨基环(-NH2),其典型的颜色无色可轻黄色液体或固体,视其纯度和形态而定.氨基化合物的存在具有基本特性,允许其参与各种化学反应,包括核循环替代和混合反应.由于它能够形成氢结,该化合物在极地溶剂(如水和酒精)中溶解,该化合物经常用于染料,药品和其他有机化合物的合成.然而,该化合物应谨慎处理,因为氨基化合物可能有毒,在接触皮肤或粘膜时可能会引起刺激.在实验室与该物质打交道时,应当遵循适当的安全议定书.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

4-(N,N-dimethylaminomethyl)nitrobenzene N-methyl-N-[2-(4-nitro-phenyl)-ethyl]-amine hydrogenchloride (4-aminomethyl)aniline acetic acid-(4-dimethylaminomethyl-anilide) phenyl>amino>-3,6-dibromo-1,4-benzoquinone hydrobromide2,5-bis4-(dimethylamino)methylphenylamino-3,6-dibromo-1,4-benzoquinone hydrobromide phenyl>amino>-3,6-dimethoxy-1,4-benzoquinone2,5-bis4-(dimethylamino)methylphenylamino-3,6-dimethoxy-1,4-benzoquinone phenyl>amino>-3,6-dichloro-1,4-benzoquinone dihydr°Chloride2,5-bis4-(dimethylamino)methylphenylamino-3,6-dichloro-1,4-benzoquinone dihydr°Chloride

合成工艺路线路线简述

  • 合成目标产物 4-Amino-N,N-Dimethylbenzylamine 主要起始原料 4-Amino-N,N-Dimethylbenzamide
  • (文献来源)合成步骤主要原料 4-Amino-N,N-Dimethylbenzamide
4-氨基-N,N-二甲基苯甲酰胺置于(5-溴-1-苯并噻吩-2-基)硼酸,苯硅烷体系中,用 甲苯 作为反应溶剂,化学反应 36.0H,以70%的收率获得产物4-(二甲基氨甲基)苯胺
参考文献:硼酸催化的氢化硅烷化将酰胺选择性还原为胺
标题:硼酸催化的氢化硅烷化将酰胺选择性还原为胺
摘要:不是'B'Ore!在存在氢硅烷的情况下,基于苯并噻吩的硼酸催化叔,仲和伯酰胺的还原.该反应显示出非常好的官能团耐受性.
DOI:10.1002/anie.201304495

海关参考信息

专利信息


专利号:US-6262272-B1
优先权日:1997-11-13
标题 :Method of synthesis of pyrrole amides
发明人:RAGAN JOHN ANTHONY; MAKOWSKI TERESA WOODALL; AM ENDE DAVID JON; CLIFFORD PAMELA JANE; YOUNG GREGORY RANDALL; CONRAD ALYSON KAY; EISENBEIS SHANE ALLEN; QUALLICH GEORGE JOSEPH; ALLEN DOUGLAS JOHN MELDRUM
权利人:PFIZER
摘要:A method for preparing pyrrole-carboxyamides which selectively bind to GABAa receptors; which comprises reacting 1,3-cycloakane-diones with bromoethylacetate followed by reaction of the resulting product with an acid halide followed by reaction with an aromatic amine and finally with an amonium source at an elevated temperature.

专利号:US-4686285-A
优先权日:1984-02-10
标题:Basic azo and non-azo compounds having one or two disubstituted 1,3,5-triazine rings each of which is linked through a bridging radical to the 1-position of a pyrazole ring
发明人:PEDRAZZI REINHARD
权利人:SANDOZ LTD
摘要:(i) Metal-free compounds of the formula ##STR1## (ii) tautomers thereof, (iii) 1:1 and 1:2 metal complexes of (i) and (ii), n (iv) salts of (i), (ii), and (iii), and n (v) mixtures of (i), (ii), (iii), and (iv), n wherein the symbols are as defined in the Specification, are useful as dyes for, for example, polymers and copolymers of acrylonitrile, polyesters modified to contain acid groups, polyamides such as wool, leather, cotton, bast fibers such as hemp, flax, sisal jute, coir and straw, regenerated cellulose, glass fibers and paper (those wherein R o is other than hydrogen) or as intermediates for the synthesis of dyes.

专利号:US-2011046395-A1
优先权日:2008-01-25
标 题 :Process for the manufacture of a 6-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene derivative
发明人:RALL WERNER; PFRENGLE WALDEMAR; SCHNAUBELT JUERGEN
权利人:BOEHRINGER INGELHEIM INT
摘要:The present invention relates to a process for the manufacture of the compound 4-[(Z)-[[4-[(dimethylamino)methyl]phenyl]amino](6-fluoro-1,2-dihydro-2-oxo-3H-in-dol-3-ylidene)methyl]-benzenepropanoic acid and to a new intermediate for the synthesis.

专利号:US-7579356-B2
优先权日:2005-05-04
标 题:Thia-tetraazaacenaphthylene kinase inhibitors
发明人:BATTISTA KATHLEEN A; BIGNAN GILLES C; CONNOLLY PETER J; HAYDEN STUART; JOHNSON SIGMOND G; LIN RONGHUI; PANDEY NIRANJAN B; POWELL MARK T
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to novel thia-tetraazaacenaphthylene compounds of Formula (I): n nand pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of ATP-protein kinase interactions.

专利号:US-2008108611-A1
优先权日:2006-01-19
标 题 :Substituted thienopyrimidine kinase inhibitors
发明人:BATTISTA KATHLEEN A; BIGNAN GILLES C; CONNOLLY PETER J; EMANUEL STUART L; HAYDEN STUART; JOHNSON SIGMOND G; LIN RONGHUI; MIDDLETON STEVEN A; PANDEY NIRANJAN B; POWELL MARK T
权利人:BATTISTA KATHLEEN A; BIGNAN GILLES C; CONNOLLY PETER J; EMANUEL STUART L; HAYDEN STUART; JOHNSON SIGMOND G; LIN RONGHUI; MIDDLETON STEVEN A; PANDEY NIRANJAN B; POWELL MARK T
摘要:The present invention is directed to thienopyrimidine compounds of formula (I): n n n n n n n n n n and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.
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合成参考文献


参考文献:10.1055/s-0033-1340021
摘要:Boronic Acid Catalyzed Hydrosilylation of Amides to Amines. Synfacts. 2013 Oct 18;9(11):1234. doi: 10.1055/s-0033-1340021.
参考文献:10.1055/a-1709-3426
摘要:Hammerstad TA, Hegde PV, Aldrich CC, Wang KJ. Chemoselective Reduction of Tertiary Amides by 1,3-Diphenyldisiloxane (DPDS). Synthesis. 2022 Jan 26;54(09):2205–12. doi: 10.1055/a-1709-3426.
参考文献:10.1007/978-3-031-37686-3_3
摘要:Ahluwalia VK. Reduction of Specific Types of Organic Compounds. 2023. In: Reduction in Organic Synthesis.
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