专利号:US-6262272-B1 优先权日:1997-11-13 标题 :Method of synthesis of pyrrole amides 发明人:RAGAN JOHN ANTHONY; MAKOWSKI TERESA WOODALL; AM ENDE DAVID JON; CLIFFORD PAMELA JANE; YOUNG GREGORY RANDALL; CONRAD ALYSON KAY; EISENBEIS SHANE ALLEN; QUALLICH GEORGE JOSEPH; ALLEN DOUGLAS JOHN MELDRUM 权利人:PFIZER 摘要:A method for preparing pyrrole-carboxyamides which selectively bind to GABAa receptors; which comprises reacting 1,3-cycloakane-diones with bromoethylacetate followed by reaction of the resulting product with an acid halide followed by reaction with an aromatic amine and finally with an amonium source at an elevated temperature.
专利号:US-4686285-A 优先权日:1984-02-10 标题:Basic azo and non-azo compounds having one or two disubstituted 1,3,5-triazine rings each of which is linked through a bridging radical to the 1-position of a pyrazole ring 发明人:PEDRAZZI REINHARD 权利人:SANDOZ LTD 摘要:(i) Metal-free compounds of the formula ##STR1## (ii) tautomers thereof, (iii) 1:1 and 1:2 metal complexes of (i) and (ii), n (iv) salts of (i), (ii), and (iii), and n (v) mixtures of (i), (ii), (iii), and (iv), n wherein the symbols are as defined in the Specification, are useful as dyes for, for example, polymers and copolymers of acrylonitrile, polyesters modified to contain acid groups, polyamides such as wool, leather, cotton, bast fibers such as hemp, flax, sisal jute, coir and straw, regenerated cellulose, glass fibers and paper (those wherein R o is other than hydrogen) or as intermediates for the synthesis of dyes.
专利号:US-2011046395-A1 优先权日:2008-01-25 标 题 :Process for the manufacture of a 6-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene derivative 发明人:RALL WERNER; PFRENGLE WALDEMAR; SCHNAUBELT JUERGEN 权利人:BOEHRINGER INGELHEIM INT 摘要:The present invention relates to a process for the manufacture of the compound 4-[(Z)-[[4-[(dimethylamino)methyl]phenyl]amino](6-fluoro-1,2-dihydro-2-oxo-3H-in-dol-3-ylidene)methyl]-benzenepropanoic acid and to a new intermediate for the synthesis.
专利号:US-7579356-B2 优先权日:2005-05-04 标 题:Thia-tetraazaacenaphthylene kinase inhibitors 发明人:BATTISTA KATHLEEN A; BIGNAN GILLES C; CONNOLLY PETER J; HAYDEN STUART; JOHNSON SIGMOND G; LIN RONGHUI; PANDEY NIRANJAN B; POWELL MARK T 权利人:JANSSEN PHARMACEUTICA NV 摘要:The present invention is directed to novel thia-tetraazaacenaphthylene compounds of Formula (I): n nand pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of ATP-protein kinase interactions.
专利号:US-2008108611-A1 优先权日:2006-01-19 标 题 :Substituted thienopyrimidine kinase inhibitors 发明人:BATTISTA KATHLEEN A; BIGNAN GILLES C; CONNOLLY PETER J; EMANUEL STUART L; HAYDEN STUART; JOHNSON SIGMOND G; LIN RONGHUI; MIDDLETON STEVEN A; PANDEY NIRANJAN B; POWELL MARK T 权利人:BATTISTA KATHLEEN A; BIGNAN GILLES C; CONNOLLY PETER J; EMANUEL STUART L; HAYDEN STUART; JOHNSON SIGMOND G; LIN RONGHUI; MIDDLETON STEVEN A; PANDEY NIRANJAN B; POWELL MARK T 摘要:The present invention is directed to thienopyrimidine compounds of formula (I): n n n n n n n n n n and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute protein kinase mediated disease, disorder or condition.
参考文献:10.1055/s-0033-1340021 摘要:Boronic Acid Catalyzed Hydrosilylation of Amides to Amines. Synfacts. 2013 Oct 18;9(11):1234. doi: 10.1055/s-0033-1340021. 参考文献:10.1055/a-1709-3426 摘要:Hammerstad TA, Hegde PV, Aldrich CC, Wang KJ. Chemoselective Reduction of Tertiary Amides by 1,3-Diphenyldisiloxane (DPDS). Synthesis. 2022 Jan 26;54(09):2205–12. doi: 10.1055/a-1709-3426. 参考文献:10.1007/978-3-031-37686-3_3 摘要:Ahluwalia VK. Reduction of Specific Types of Organic Compounds. 2023. In: Reduction in Organic Synthesis.