专利号:WO-2010039911-A1 优先权日:2008-10-01 标题 :Calcilytic compounds 发明人:JEONG JAE U; MARQUIS ROBERT W JR 权利人:GLAXOSMITHKLINE LLC; JEONG JAE U; MARQUIS ROBERT W JR 摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.
参考标题:Reprogramming Epoxide Hydrolase To Improve Enantioconvergence In Hydrolysis Of Styrene Oxide Scaffolds 作者:Fu‐long Li,Yan‐yan Qiu,Yu‐cong Zheng,Fei‐fei Chen,Xu-Dong Kong,Jian‐he Xu,Hui‐lei Yu |发布日期:2020.11.4 摘要:Enantioconvergent Hydrolysis By Epoxide Hydrolase Is A Promising Method For The Synthesis Of Important Vicinal Diols. However, The Poor Regioselectivity Of The Naturally Occurring Enzymes Results In Low Enantioconvergence In The Enzymatic Hydrolysis Of Styrene Oxides. Herein, Modulated Residue No. 263 Was Redesigned Based On Structural Information And A Smart Variant Library Was Constructed By Site‐directed
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