CAS: 62717-50-4; 2-(2-Chlorophenyl)Oxirane

该化合物是一种多用途有机化合物,含有氯联苯组和氧气环,具有高度的活性,适合各种合成变异,其主要优势包括其稳定性,易于处理和能够接受环状反应,使其成为合成药物和精细化学品的宝贵中间体.

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CAS号16355-00-3 (R)-(-)-1-苯基-1,2-乙二醇 | CAS号873-32-5 邻氯苯腈 | CAS号32345-65-6 (DL)-o-chloroph... | CAS号118-91-2 邻氯苯甲酸

合成工艺路线路线简述

    📜1-(2-氯苯基)乙醇置于potassium Hydrogensulfate,碳酸氢钠,对苯二酚,间氯过氧苯甲酸体系中,用 二氯甲烷 作为反应溶剂,化学反应 9.0H,反应生成 2-氯苯基环氧乙烷
    参考文献:一种化合物妥洛特罗的合成方法
    标题:一种化合物妥洛特罗的合成方法
    摘要:本发明涉及一种化合物妥洛特罗的合成方法,其解决了现有方法存在安全隐患,成本较高的技术问题,该方法包括如下步骤:(A)烯化反应:以1‑(2‑氯苯基)‑1‑乙醇为起始原料,在催化剂和酸存在下,加热反应反应生成2‑氯苯乙烯;(B)成环反应:以2‑氯苯乙烯为原料,在碱和氧化剂存在的条件下,进行环氧化反应得到2‑(2‑氯苯基)环氧乙烷;(C)开环反应:以2‑(2‑氯苯基)环氧乙烷为原料,与叔丁胺反应得到化合物1‑(2‑氯苯基)‑2‑叔丁氨基乙醇.本发明可用于妥洛特罗的制备.

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    专利信息


    专利号:WO-2010039911-A1
    优先权日:2008-10-01
    标题 :Calcilytic compounds
    发明人:JEONG JAE U; MARQUIS ROBERT W JR
    权利人:GLAXOSMITHKLINE LLC; JEONG JAE U; MARQUIS ROBERT W JR
    摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.

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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:Reprogramming Epoxide Hydrolase To Improve Enantioconvergence In Hydrolysis Of Styrene Oxide Scaffolds
    作者:Fu‐long Li,Yan‐yan Qiu,Yu‐cong Zheng,Fei‐fei Chen,Xu-Dong Kong,Jian‐he Xu,Hui‐lei Yu |发布日期:2020.11.4
    摘要:Enantioconvergent Hydrolysis By Epoxide Hydrolase Is A Promising Method For The Synthesis Of Important Vicinal Diols. However, The Poor Regioselectivity Of The Naturally Occurring Enzymes Results In Low Enantioconvergence In The Enzymatic Hydrolysis Of Styrene Oxides. Herein, Modulated Residue No. 263 Was Redesigned Based On Structural Information And A Smart Variant Library Was Constructed By Site‐directed

    合成参考文献


    摘要:Kawęcki, R., Science of Synthesis Knowledge Updates, (2018) 4, 323.
    摘要:Li, A. T.; Li, Z., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 2, 494.
    摘要:Wohlgemuth, R., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 2, 534.
    摘要:Li, A. T.; Li, Z., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 2, 495.
    参考文献:10.1007/s10529-012-1114-1
    摘要:Woo JH, Kwon TH, Kim JT, Kim CG, Lee EY. Identification and characterization of epoxide hydrolase activity of polycyclic aromatic hydrocarbon-degrading bacteria for biocatalytic resolution of racemic styrene oxide and styrene oxide derivatives. Biotechnol Lett. 2013 Apr;35(4):599–606. doi: 10.1007/s10529-012-1114-1.
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