CAS: 60666-70-8; (2-Bromo-5-Chlorophenyl)Methanol

上下游产品

CAS号21739-93-5 2-溴-5-氯苯甲酸 | CAS号174265-12-4 2-溴-5-氯苯甲醛 | CAS号27007-53-0 2-溴-5-氯苯甲酸甲酯 | CAS号174265-12-4 2-溴-5-氯苯甲醛 | CAS号54109-03-4 5-氯-1(3H)-异苯并呋喃酮

2-溴-5-氯苯甲醛置于sodium Tetrahydroborate体系中,用 甲醇 作为反应溶剂,化学反应 0.17H,反应生成 2-溴-5-氯苯甲醇
参考文献:经由与weinreb酰胺帕海姆型环化的4-异色满酮类的高效合成
标题:经由与weinreb酰胺帕海姆型环化的4-异色满酮类的高效合成
摘要:4-异色满酮类经由帕海姆型环化的weinreb合成酰胺作为内部电子基团,吨正丁基锂作为被描述的锂试剂.该反应是有效的,并且可以在一分钟内完成.这个新的协议的应用范围进行了研究和所需产物可以以非常好地获得优异的产率.此外,该方法的合成潜力还通过天然产物(+/-)-Xjp的合成得到了进一步证明,该合成是通过六个步骤获得的,总收率高达54%.
DOI:10.1016/j.Tet.2015.08.028

专利信息

专利号:US-8106031-B2
优先权日:2006-05-02
标题:Hydrolytically-resistant boron-containing therapeutics and methods of use
发明人：LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A
权利人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A; ANACOR PHARMACEUTICALS INC
摘要:Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.

专利号:US-7968752-B2
优先权日:2003-06-16
标 题:Hydrolytically-resistant boron-containing therapeutics and methods of use
发明人：LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A
权利人:ANACOR PHARMACEUTICALS INC
摘要:Compositions and methods of use of borole derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.