专利号:US-9433605-B2 优先权日:2006-03-23 标 题 :Method for promoting synthesis of tissue collagen 发明人:KAMIYA TOSHIKAZU; KAMIMURA AYAKO; KAWADA YOKO 权利人:KYOWA HAKKO BIO CO LTD 摘要:An object of the present invention is to provide an oral preparation for promoting synthesis of tissue collagen, an oral preparation for promoting healing of skin wounds or an oral preparation for preventing or improving skin wrinkles or sagging, which is safe and has an excellent effect. The present invention can provide an oral preparation for promoting synthesis of tissue collagen, an oral preparation for promoting healing of skin wounds or an oral preparation for preventing or improving skin wrinkles or sagging, which comprises hydroxyproline or a salt thereof as an active ingredient.
专利号:WO-2011097717-A1 优先权日:2010-02-15 标 题 :Synthesis of bicyclic compounds and method for their use as therapeutic agents 发明人:WULFF JEREMY EARLE; BRANT MICHAEL GLENN; BROMBA CALEB MATTHEW; BOULANGER MARTIN JOHN 权利人:UNIV VICTORIA INNOVAT DEV; WULFF JEREMY EARLE; BRANT MICHAEL GLENN; BROMBA CALEB MATTHEW; BOULANGER MARTIN JOHN 摘要:Disclosed embodiments concern the synthesis and use of therapeutic compounds that for treating emerging flu strains and minimizing resistance to such strains. Methods for making the disclosed compounds concern using a base-mediated addition/cyclization sequence followed by functional group manipulation to develop functionalized compounds that can target neuraminidase, which makes them ideal candidates for treating influenza. Pharmaceutical compositions comprising the therapeutic compounds and biologically-acceptable materials are also described. Methods of inhibiting neuraminidase in subjects that are suspected of containing neuraminidase are also described. The use of metabolites of the disclosed compounds can also be used in diagnostic assays for therapeutic dosing of the disclosed compounds.
专利号:US-8883846-B2 优先权日:2010-02-15 标题:Synthesis of bicyclic compounds and method for their use as therapeutic agents 发明人:WULFF JEREMY E; BRANT MICHAEL G; MASON JEREMY W; BROMBA CALEB M; BOULANGER MARTIN J 权利人:WULFF JEREMY E; BRANT MICHAEL G; MASON JEREMY W; BROMBA CALEB M; BOULANGER MARTIN J; UVIC INDUSTRY PARTNERSHIPS INC 摘要:Disclosed embodiments concern the synthesis and use of therapeutic compounds that for treating emerging flu strains and minimizing resistance to such strains. Methods for making the disclosed compounds concern using a base-mediated addition/cyclization sequence followed by functional group manipulation to develop functionalized compounds that can target neuraminidase, which makes them ideal candidates for treating influenza. Pharmaceutical compositions comprising the therapeutic compounds and biologically-acceptable materials are also described. Methods of inhibiting neuraminidase in subjects that are suspected of containing neuraminidase are also described. The use of metabolites of the disclosed compounds can also be used in diagnostic assays for therapeutic dosing of the disclosed compounds.
专利号:EP-1779900-B1 优先权日:2005-10-29 标 题 :Cosmetic or dermatological composition for prevention of light-induced aging 发明人:NEUFANG HARTMUT; TILL MARTINA 权利人:APOTHEKER WALTER BOUHON GMBH 摘要:Use of a composition (I) comprising vitamin A (0.02-0.09 wt.%), phytosterol (0.1-3 wt.%), vitamin E (0.5-3 wt.%) and their biochemical precursors or derivatives, for the production of cosmetic or dermatological preparation for the inhibition of a light-induced gene expression of the synthesis of a collagenase in the skin. An independent claim is included for the cosmetic or dermatological preparation comprising (I), urea (1-4 wt.%), caprylic/capric acid triglyceride (caprylic/capric triglyceride according to INCI standard), lipids, consistency agents, emulsifying agents, polymers, perfumes, preservatives and water. ACTIVITY : Dermatological. MECHANISM OF ACTION : Gene expression of synthesis of collagenase Inhibitor.
专利号:US-2024239791-A1 优先权日:2021-04-26 标题 :Processes for the synthesis of valbenazine 发明人:TUCKER JOHN LLOYD 权利人:NEUROCRINE BIOSCIENCES INC 摘要:The present application relates to processes for preparing (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate), which is an inhibitor of vesicular monoamine transporter 2 (VMAT2) useful in the treatment of hyperkinetic movement disorders such as tardive dyskinesia (TD).
专利号:US-2022363680-A1 优先权日:2019-09-13 标题 :Processes for the synthesis of valbenazine 发明人:TUCKER JOHN; KUCERA DAVID; HETTINGER DONALD; COCHRAN BRIAN M; BRANUM SHAWN; LE JACKIE; MCGEE KEVIN 权利人:NEUROCRINE BIOSCIENCES INC 摘要:The present application relates to processes for making (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b -hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl (S)-2-amino-3-methylbutanoate di(4-methylbenzenesulfonate), which is an inhibitor of vesicular monoamine transporter 2 (VMAT2) useful in the treatment of hyperkinetic movement disorders such as tardive dyskinesia (TD).
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合成参考文献
摘要:Weast, R.C. (ed.). Handbook of Chemistry and Physics. 60th ed. Boca Raton, Florida: CRC Press Inc., 1979., p. B-95 摘要:21 CFR 184.1440; U.S. National Archives and Records Administration's Electronic Code of Federal Regulations. Available from, as of October 22, 2002: 摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118 摘要:International Journal of Toxicology 22(Suppl. 1):1-35, 2003 摘要:Final Report 04/2019 Available from CIR