CAS: 542-76-7; 3-Chloropropanenitrile

上下游产品

potassium cyanide 1-Bromo-2-chloroethane chloroform acrylonitrile 3-(pyrrolidin-1-yl)propanenitrile 3-Morpholin-4-yl-propionitrile 1-(2-cyano-ethyl)-pyridinium; chloride Methyl 3-chloropropionimidate hydr°Chloride

📜4-氯丙酸置于三氟乙酸,三氟乙酸酐,Sodium Nitrite体系中,用59%的收率获得产物β-氯丙腈
参考文献:Smushkevich,Y. I.; Smushkevich,V. Y.; Usorov,M. I.,Journal Of Chemical Research,Miniprint,1999,# 7,P. 1727-1736
标题:Smushkevich,Y. I.; Smushkevich,V. Y.; Usorov,M. I.,Journal Of Chemical Research,Miniprint,1999,# 7,P. 1727-1736

专利信息

专利号:US-2004106829-A1
优先权日:2002-11-12
标题 :Process for the synthesis of modafinil
发明人：FORNAROLI MIRCO; VELARDI FRANCESCO; COLLI CORRADO; BAIMA ROBERTO
权利人:PROCOS SPA
摘要:The present invention relates to a process for the preparation of 2-(benzhydrylthio)acetamide (II), key intermediate for the synthesis of modafinil, by reaction of benzhydryl chloride with thiourea and chloroacetamide.

专利号:US-4365094-A
优先权日:1979-12-28
标 题 :Process for the synthesis of tertiary phosphine oxides, and new tertiary phosphine oxides
发明人：BOILEAU SYLVIE L; N GUYEN THANH-DUNG; GAUTIER JEAN-CLAUDE C
权利人:POUDRES & EXPLOSIFS STE NALE
摘要:The invention relates to the synthesis of tertiary phosphine oxides and also to certain tertiary phosphine oxides. According to the invention, an organic phase containing a halogenomethyl derivative, a secondary phosphine oxide and a phase transfer catalyst in an organic medium is reacted with an aqueous phase containing an inorganic base. The halogenomethyl derivative can be a micromolecule or a macromolecule. The tertiary phosphine oxides are substances which are useful, in particular, in fireproofing, in hydrometallurgy and in the field of plant health.

专利号:US-5856500-A
优先权日:1997-03-11
标题:Synthesis of thiazole derivatives
发明人：MATTHEWS MICHAEL D; MALCOLM ARCELIO J
权利人:ALBEMARLE CORP
摘要:N- 4-(Cyanoethylthiomethyl)-2-thiazolyl!guanidine, is prepared by (a) mixing 1,3-dihaloacetone and 2-imino-4-thiobiuret in a suitable polar organic solvent at initial temperatures of about -10° to about 25° C., and agitating the mixture at about -10° to about 60° C. for at least about 1 hour; (b) heating the resultant mixture at about 40° to about 60° C. for at least about 0.5 hour; (c) mixing with the mixture from (b), thiourea and then water at about 40° to about 60° C. for a period of at least about 1 hour; (d) removing liquid polar solvent from the mixture of (c); and (e) mixing with the mixture from (d), 3-halopropionitrile and water-soluble alcohol, ether, or ether-alcohol, followed by aqueous alkali metal hydroxide while maintaining the temperature at below about 20° C., to form N- 4-(cyanoethylthiomethyl)-2-thiazolyl!guanidine. The process avoids isolating and purifying any of the intermediates, and can be conducted in the same vessel, as a 'one-pot' synthesis.

专利号:US-5856501-A
优先权日:1997-03-11
标题 :Synthesis of thiazole derivatives
发明人：MALCOLM ARCELIO J; WU TSE-CHONG
权利人:ALBEMARLE CORP
摘要:N- 4-(cyanoethylthiomethyl)-2-thiazolyl!guanidine--a key intermediate for preparing the pharmaceutical, famotidine--is produced by mixing in a liquid medium formed from a chemically indifferent organic solvent and water, and under an inert atmosphere, (i) a 2-guanidino-4-halomethylthiazole or a hydrohalide complex thereof, (ii) an S-(2-cyanoethyl)isothiourea or a hydrohalide complex thereof, and (iii) a strong alkali metal base. In lieu of (ii), an alkali metal salt of 2-cyanoethyl-1-thiol can be used, and in such case use of (iii) is optional, but preferable.

专利号:US-4536599-A
优先权日:1978-08-22
标题:Synthesis of amine derivatives
发明人：MASUKO FUJIO; KATSURA TADASHI
权利人:SUMITOMO CHEMICAL CO
摘要:An amine of the formula, ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including α-phenyl-β-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, ##STR2## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, ##STR3## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.

专利号:US-5344924-A
优先权日:1991-02-20
标 题 :Solvent-free synthesis of ethereally substituted blocked monosaccharides and the selective hydrolysis thereof
发明人：ARORA SUDERSHAN K
权利人:GREENWICH PHARMA
摘要:A solvent-free method for synthesizing an ethereally-substituted, blocked monosaccharide comprising the steps of: n 1) mixing, in the absence of solvent, a partially blocked monosaccharide unblocked at one position, an alkyl halide or a substituted alkyl halide, and an anhydrous alkali base; n 2) heating the mixture to a temperature sufficient to allow the mixture to react; n 3) maintaining the mixture at a suitable temperature for a time sufficient to form an ethereally-substituted blocked monosaccharide and drive off any water produced; n 4) removing any unreacted alkyl halide or substituted alkyl halide from the mixture; n 5) recovering the ethereally-substituted blocked monosaccharide product from the mixture; and, optionally, n 6) selectively hydrolyzing the ethereally-substituted blocked monosaccharide product to remove one or more of the acetal blocking groups.