CAS: 511295-01-5; (2,3,5,6-Tetrafluorophenyl)Boronic Acid

该化合物是一种氟化丙烯酸衍生物,广泛用作有机合成和交叉组合反应的多用途构件,特别是在铃木-宫浦交织中.四氟原子的存在增强了其反应性和稳定性,使其对建设复杂的氟芳芳烃系统具有价值.其电阻脱色特性提高了催化转化的反应效率.该化合物还用于材料科学和制药研究,其中氟化质素对于调整物理化学特性至关重要.高纯度和持续性能使它成为要求合成应用的可靠试剂.建议在惰性条件下进行妥善处理,因为其对水分感.

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CAS号121-43-7 硼酸三甲酯 | CAS号327-54-8 1,2,4,5-四氟苯 | CAS号7732-18-5 水 | CAS号327-54-8 1,2,4,5-四氟苯

合成工艺路线路线简述

    📜硼酸三甲酯,1,2,4,5-四氟苯置于正丁基锂体系中,用 乙醚,正己烷 作为反应溶剂,以48%的收率获得产物2,3,5,6-四氟苯硼酸
    参考文献:
    标题:
    摘要:A General Preparative Procedure For Polyfluorinated Aryl(Dihydroxy)Boranes C6H5-Nfnb(Oh)(2) (N = 3-5) Is Described. Polyfluorinated Aryl(Dihydroxy)Boranes Are Easily Dehydrated To The Corresponding Tri(Aryl)Boroxins (C6H5-Nfnbo)(3) By Thermal Or Chemical Treatment. The Property Of The Acids C6H5-Nfnb(Oh)(2) To Condensate Depends On The Number And On The Position Of The Fluorine Atoms In The Aryl Group. Examples Of Both Classes Of Boron Compounds Were Isolated As Pure Individuals And Characterized By Multinuclear NMR Spectroscopy.
    DOI:10.1002/1521-3749(200213)628:13<2827::Aid-Zaac2827>3.0.Co;2-N

    专利信息


    专利号:US-11225655-B2
    优先权日:2010-04-16
    标题:Bi-functional complexes and methods for making and using such complexes
    发明人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
    权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
    摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

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    ✅ COA系统入驻 | 共享模式

    合成参考文献

    参考DOI号:3.0.CO;2-N">10.1002/1521-3749(200213)628:13<2827::AID-ZAAC2827>3.0.CO;2-N
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