CAS: 500-64-1; (R,E)-4-Methoxy-6-Styryl-5,6-Dihydro-2H-Pyran-2-One

上下游产品

(E)-3-phenylpropenal ((E)-1,3-Dimethoxy-buta-1,3-dienyloxy)-trimethyl-silane ethyl γ-bromo-β-methoxy-cis-crotonate 3-phenyl-propenal7,8-dihydrokawain 5-((E)-2-Hydroxy-4-phenyl-but-3-enyl)-1,2-dihydro-pyrazol-3-one 5,6-dehydrokawain 7,8-dihydrokavain

(E)-(R)-5-Hydroxy-3-Oxo-7-Phenyl-Hept-6-Enoic Acid Methyl Ester置于potassium Carbonate体系中,用 甲醇,丙酮 作为反应溶剂,化学反应 15.17H,反应生成 醉椒素
参考文献:A New Procedure For The Enantioselective Vinylogous Aldol Reaction Of Chan's Diene
标题:A New Procedure For The Enantioselective Vinylogous Aldol Reaction Of Chan's Diene
摘要:Chiral Delta-Hydroxy-Delta-Ketoesters Are Easily Available Through The Enantio Selective Vinylogous Aldol Reaction Of Chan'S Diene Promoted By A Sicl4/chiral Phosphoramide Catalytic System. The Procedure Is Conveniently Exploited For A Very Rapid Approach To (+)-Kavain,A Natural Bio-Active Alpha-Pyrone Compound. (C) 2007 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tetasy.2006.12.016

专利信息

专利号:US-11746364-B2
优先权日:2018-01-17
标题 :Enzymatic synthesis of kavalactones and flavokavains
发明人：PLUSKAL TOMÃ?S; Weng jing-ke
权利人:WHITEHEAD INST BIOMEDICAL RES
摘要:Disclosed are methods, compositions, proteins, nucleic acids, cells, vectors, compounds, reagents, and systems for the preparation of kavalactones, flavokavains, and kavalactone and flavokavain biosynthetic intermediates using enzymes expressed in heterologous host cells, such as microorganisms or plants, or using in vitro enzymatic reactions. This invention also provides for the expression of the enzymes by recombinant cell lines and vectors. Furthermore, the enzymes can be components of constructs such as fusion proteins. The kavalactones produced can be utilized to treat anxiety disorder, insomnia, and other psychological and neurological disorders. The flavokavains produced can be utilized to treat various cancers including colon, bladder, and breast cancers.

专利号:US-6677462-B2
优先权日:2001-08-06
标题:Asymmetric synthesis of kavalactones
发明人：CHEN SHOUJUN; SUN LIJUN; MCCLEARY JOEL
权利人:KAVA PHARMACEUTICALS INC
摘要:This invention relates to preparation of enantio-enriched compounds, and more particularly to enantio-enriched kavalactone compounds and derivatives thereof. The methods provide compounds that are useful as reagents, or building blocks, in the construction of other enantio-enriched compounds.

专利号:US-2019271015-A1
优先权日:2018-01-17
标题 :Enzymatic synthesis of kavalactones and flavokavains

专利号:US-10941429-B2
优先权日:2018-01-17
标 题:Enzymatic synthesis of kavalactones and flavokavains

专利号:CA-2456720-A1
优先权日:2001-08-06
标题 :Asymmetric synthesis of kavalactones

专利号:EP-1414463-A4
优先权日:2001-08-06
标题 :ASYMMETRIC SYNTHESIS OF KAVALACTONES