CAS: 497-73-4; Neomethymycin

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Yc-17 36826-66-1

📜在 水,三乙胺体系中,用 甲醇 作为反应溶剂,以80%的收率获得产物新酒霉素
参考文献:新甲霉素和新甲霉素的全合成
标题:新甲霉素和新甲霉素的全合成
摘要:已经实现了新甲霉素和新甲霉素的全合成.这两个大环内酯类含有12元大内酯作为糖苷配基,属于抗生素的间霉素家族,出现在吡咯霉素的生物合成途径中.通过从d-(+)-乳酸甲酯和d开始合成12元大内酯中导致新霉素和新霉素发生结构差异的部分-葡萄糖分别用于新甲氧苄啶和新甲氧苄啶.分别是新甲霉素和新甲霉素的糖苷配基的新甲氧嘧啶和新甲氧嘧啶的合成关键步骤是不对称醛醇缩合反应,山口酯化和使用格鲁布斯第二代催化剂进行的闭环复分解.最后,将戊二烯酮与相应的三氯乙酰亚氨酸酯偶联,然后脱保护,完成了这两种大环内酯类抗生素的总合成.
DOI:10.1016/j.Tet.2010.04.039

专利信息

专利号:US-2008044860-A1
优先权日:2003-11-28
标题 :Polyketides and Their Synthesis
发明人：GAISSER SABINE; HAYDOCK STEPHEN FREDERICK; LEADLAY PETER FRANCIS; MCARTHUR HAMISH ALASTAIR IRVIN
权利人:GAISSER SABINE; HAYDOCK STEPHEN FREDERICK; LEADLAY PETER FRANCIS; MCARTHUR HAMISH ALASTAIR IRVIN
摘要:Macrolides particularly erythromycins and azithromycins, having O-mycaminosyl or O-angolosaminyl groups, particularly at the 5 -position, are produced using a gene cassette comprising a combination of genes which, in an appropriate strain background, are able to direct the synthesis of mycaminose or angolosamine and to direct its subsequent transfer to an aglycone or pseudoaglycone. Synthetic genes may comprise one or more of angMIII, angMI, angB, angAI, angAII, angorf14, angorf4, tylMIII, tylMI, tylB, tylAI, tylAII, eryCVI, spnO, eryBVI, eryK, tyl Ia and ery G. Glycosyltransfer genes may comprise one or more of eryCIII, tylMII, angMII, desVII, eryBV, spnP and midI.

专利号:US-2003194784-A1
优先权日:2001-04-17
标题:DNA encoding methymycin and pikromycin
发明人：SHERMAN DAVID H; LIU HUNG-WEN; XUE YONGQUAN; ZHAO LISHAN
摘要:A novel pathway for the synthesis of polyhydroxyalkanoates is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalkanoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalkanoate synthase. Also provided is a biosynthetic gene cluster for methymycin and pikomycin as well as a biosynthetic gene cluster for desosamine.

专利号:US-6265202-B1
优先权日:1998-06-26
标 题 :DNA encoding methymycin and pikromycin
发明人：SHERMAN DAVID H; LIU HUNG-WEN; XUE YONGQUAN; ZHAO LISHAN
权利人:UNIV MINNESOTA
摘要:A novel pathway for the synthesis of polyhydroxyalkanoates is provided. A method of synthesizing a recombinant polyhydroxyalkanoate monomer synthase is also provided. These recombinant polyhydroxyalkanoate synthases are derived from multifunctional fatty acid synthases or polyketide synthases and generate hydroxyacyl acids capable of polymerization by a polyhydroxyalkanoate synthase. Also provided is a biosynthetic gene cluster for methymycin and pikomycin as well as a biosynthetic gene cluster for desosamine.

专利号:US-6509455-B1
优先权日:1997-04-30
标题:Recombinant narbonolide polyketide synthase
发明人：ASHLEY GARY; BETLACH MELANIE C; BETLACH MARY; MCDANIEL ROBERT; TANG LI
权利人:KOSAN BIOSCIENCES INC
摘要:Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.

专利号:US-6902913-B2
优先权日:1997-04-30
标题:Recombinant narbonolide polyketide synthase
发明人：BETLACH MELANIE C; BETLACH MARY; MCDANIEL ROBERT; TANG LI
权利人:KOSAN BIOSCIENCES INC
摘要:Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.