Squalene 反应生成 4-(1,5-二甲基-4-己烯亚基)-1-甲基环己烯 参考文献:Heilbron; Kamm; Owens,Journal Of The Chemical Society,1926,P. 1634,1642 标题:Heilbron; Kamm; Owens,Journal Of The Chemical Society,1926,P. 1634,1642
专利号:US-2018105838-A1 优先权日:2015-03-11 标 题:Process for de novo microbial synthesis of terpenes 发明人:SCHRADER JENS; BUCHHAUPT MARKUS; SONNTAG FRANK; KRONER CORA; BRÜSER HEIKE; Schröder Hartwig; PELZER RALF 权利人:BASF SE 摘要:The invention relates to microbial terpene production. Known methods for microbial production of terpenes are mostly based on the direct conversion of sugars. Therefore alternative substrates, in particular alternative carbon sources, for use in microbial terpene production were desirable. The invention relates to a methylotrophic bacterium containing recombinant DNA coding for at least one polypeptide with enzymatic activity for heterologous expression in said bacterium, wherein said at least one polypeptide with enzymatic activity is selected from the group consisting an enzyme of a heterologous mevalonate pathway, a heterologous terpene synthase and optionally a heterologous synthase of a prenyl diphosphate precursor. The invention further relates in particular to a method for de novo microbial synthesis of sesquiterpenes or diterpenes from methanol and/or ethanol.
专利号:US-11384367-B2 优先权日:2016-12-22 标题:Synthesis of bioproducts from lignin-derived aromatics by genetically modified microorganisms 发明人:GLADDEN JOHN M; SKERKER JEFFREY M; KEASLING JAY D; KIRBY JAMES; YAEGASHI JUNKO 权利人:UNIV CALIFORNIA; NAT TECH & ENG SOLUTIONS SANDIA LLC; BATTELLE MEMORIAL INSTITUTE FOR MANAGEMENT AND OPERATION OF PACIFIC NORTHWEST NAT LABORATORY; NATIONAL TECH AND ENGINEERING SOLUTIONS OF SANDIA LLC 摘要:The present invention provides for a method of converting a depolymerized lignin aromatic compound into a bioproduct, comprising: (a) providing a composition comprising a depolymerized lignin aromatic compound, optionally a depolymerized cellulose, and optionally a depolymerized hemicellulose, and (b) introducing a genetically modified microorganism to the composition, wherein the genetically modified microorganism is capable of converting the depolymerized lignin aromatic compound into a bioproduct; such that the depolymerized lignin aromatic compound is converted into a bioproduct.
专利号:US-11052374-B2 优先权日:2018-12-20 标题:Surfactant-templated synthesis of nanostructured xerogel adsorbent platforms 发明人:DE LEON PATRICIA IGNACIO; LAIBLE PHILIP D; MEYER MACKENZIE ELIZABETH; POVINELLI CHRISTOPHER R; TRACEY KILLIAN L; ARENAS DANIEL YOAV 权利人:UCHICAGO ARGONNE LLC 摘要:A process for separations and recovery from mixtures via specific adsorption using high-surface area, flexible silica-based nanostructured gel adsorbents and articles of manufacture relating to same.
专利号:US-10144840-B2 优先权日:2013-03-13 标题 :One-pot, high-performance recycling of polymer waste using renewable polymer synthesis 发明人:HEARON KEITH 权利人:POLY6 TECH 摘要:Curable formulations, cured formulations, and mixtures and composites thereof are described herein, as well as methods of making and using the formulations, mixtures, and composites.
专利号:DE-102015103608-A1 优先权日:2015-03-11 标题 :Process for the microbial de novo synthesis of terpenes
专利号:CN-107429223-A 优先权日:2015-03-11 标 题 :Methods for de novo microbial synthesis of terpenoids
1: Jou YJ, Chen CJ, Liu YC, Way TD, Lai CH, Hua CH, Wang CY, Huang SH, Kao JY, Lin CW. Quantitative phosphoproteomic analysis reveals γ-bisabolene inducing p53-mediated apoptosis of human oral squamous cell carcinoma via HDAC2 inhibition and ERK1/2 activation. Proteomics. 2015 Oct;15(19):3296-309. doi: 10.1002/pmic.201400568. Epub 2015 Aug 13. pii: E601. doi: 10.3390/molecules21050601. doi: 10.3389/fbioe.2014.00021. eCollection 2014. 4: Aschenbrenner AK, Kwon M, Conrad J, Ro DK, Spring O. Identification and characterization of two bisabolene synthases from linear glandular trichomes of sunflower (Helianthus annuus L., Asteraceae). Phytochemistry. 2016 Apr;124:29-37. doi: 10.1016/j.phytochem.2016.01.009. Epub 2016 Feb 12. doi: 10.1021/sb5002517. Epub 2014 Jul 9. doi: 10.1007/s11103-015-0381-3. Epub 2015 Oct 6. doi: 10.1002/ptr.5543. Epub 2015 Dec 15. Epub 2014 Jan 17. doi: 10.1021/ja4106489. Epub 2014 Feb 3. doi: 10.1021/acs.orglett.6b01519. Epub 2016 Jun 24. doi: 10.1016/j.bmcl.2015.12.022. Epub 2015 Dec 8. doi: 10.1016/j.yebeh.2012.02.020. Epub 2012 Apr 5. doi: 10.1128/AEM.02155-14. Epub 2014 Aug 22. 14: Mao SC, Guo YW, van Soest R, Cimino G. Trans-dimer D, a novel dimeric sesquiterpene with a bis-bisabolene skeleton from a Hainan sponge Axinyssa variabilis. J Asian Nat Prod Res. 2011 Aug;13(8):770-5. doi: 10.1080/10286020.2011.588949.
合成参考文献
参考文献:10.1080/10286020.2011.588949 摘要:Mao S, Guo Y, van Soest R, Cimino G. Trans-dimer D, a novel dimeric sesquiterpene with a bis-bisabolene skeleton from a Hainan spongeAxinyssa variabilis. Journal of Asian Natural Products Research. 2011 Aug;13(8):770–5. doi: 10.1080/10286020.2011.588949.