📜丁基硫基苯置于三氯化铝体系中,化学反应生成 卡普托胺 参考文献:Takahashi,K. Et Al.,Chemical And Pharmaceutical Bulletin,1960,Vol. 8,P. 757-762 标题:Takahashi,K. Et Al.,Chemical And Pharmaceutical Bulletin,1960,Vol. 8,P. 757-762
专利号:US-10351492-B2 优先权日:2015-02-16 标题 :Introduction of alkyl substituents to aromatic compounds 发明人:PAPPO DORON; PARNES REGEV 权利人:B G NEGEV TECHNOLOGIES AND APPLICATIONS LTD AT BEN GURION UNIV; B G NEGEV TECH AND APPLICATIONS 摘要:Novel selective synthesis route to introduce primary alkyl groups on aromatic compounds is disclosed. The synthesis route is based on electrophilic aromatic substitutions of thionium ion species that are generated in-situ from aldehydes and thiols, affording benzyl sulfide that can be reduced with triethylsilane.
专利号:US-7749985-B2 优先权日:2006-09-15 标 题 :Acyloxyalkyl carbamate prodrugs, methods of synthesis and use 发明人:GALLOP MARK A; XU FENG; PHAN THU; DILIP USHA; PENG GE 权利人:XENOPORT INC 摘要:Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs 3-aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.
专利号:US-2023271983-A1 优先权日:2020-07-29 标题 :Functionalized isonitriles and products, preparation and uses thereof 发明人:SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA 权利人:UNIV SANTIAGO COMPOSTELA 摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.
专利号:US-2008146526-A1 优先权日:2006-09-15 标 题 :Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
专利号:US-2009286759-A1 优先权日:2006-09-15 标题:Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
专利号:WO-2008033572-A1 优先权日:2006-09-15 标题:Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
1: ABBOTT LG. Neurodermatoses and captodiame. Aust J Dermatol. 1960 Jun;5:187-90. doi: 10.1002/14651858.CD011481.pub2. Review.
合成参考文献
摘要:Archives Internationales de Pharmacodynamie et de Therapie., 136(440), 1962 [] 摘要:Arzneimittel-Forschung. Drug Research., 8(154), 1958 [] 摘要:Journal of Pharmacology and Experimental Therapeutics., 108(201), 1953 [] 摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664