CAS: 486-17-9; Captodiame

该化合物是有能力抑制恶性疟原虫种的生长,使其成为治疗疟疾的一种宝贵化合物;该物质通常通过药物配方施用,其功效经常在临床环境中评估;在物理特性方面,Captodiame一般在室温下是固态的,具有影响其生物利用率和治疗效力的特定溶性特征;安全和毒性特征是其使用中的基本考虑因素,与任何药剂一样,并且继续研究其潜在用途和机制;

结构式图片

MSDS等安全信息

    上下游产品

    CAS号1126-80-3 Benzene, (butylthio) | CAS号98-88-4 苯甲酰氯 | CAS号73242-21-4 [4-(BUTYLTHIO)P... | CAS号4584-46-7 二甲氨基氯乙烷盐酸

    合成工艺路线路线简述

      📜丁基硫基苯置于三氯化铝体系中,化学反应生成 卡普托胺
      参考文献:Takahashi,K. Et Al.,Chemical And Pharmaceutical Bulletin,1960,Vol. 8,P. 757-762
      标题:Takahashi,K. Et Al.,Chemical And Pharmaceutical Bulletin,1960,Vol. 8,P. 757-762

      海关参考信息

      专利信息


      专利号:US-10351492-B2
      优先权日:2015-02-16
      标题 :Introduction of alkyl substituents to aromatic compounds
      发明人:PAPPO DORON; PARNES REGEV
      权利人:B G NEGEV TECHNOLOGIES AND APPLICATIONS LTD AT BEN GURION UNIV; B G NEGEV TECH AND APPLICATIONS
      摘要:Novel selective synthesis route to introduce primary alkyl groups on aromatic compounds is disclosed. The synthesis route is based on electrophilic aromatic substitutions of thionium ion species that are generated in-situ from aldehydes and thiols, affording benzyl sulfide that can be reduced with triethylsilane.

      专利号:US-7749985-B2
      优先权日:2006-09-15
      标 题 :Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
      发明人:GALLOP MARK A; XU FENG; PHAN THU; DILIP USHA; PENG GE
      权利人:XENOPORT INC
      摘要:Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs 3-aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.

      专利号:US-2023271983-A1
      优先权日:2020-07-29
      标题 :Functionalized isonitriles and products, preparation and uses thereof
      发明人:SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
      权利人:UNIV SANTIAGO COMPOSTELA
      摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.

      专利号:US-2008146526-A1
      优先权日:2006-09-15
      标 题 :Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

      专利号:US-2009286759-A1
      优先权日:2006-09-15
      标题:Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

      专利号:WO-2008033572-A1
      优先权日:2006-09-15
      标题:Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

      供应商参考报价(招募中)

      品牌试剂参考报价(招募中)

      📌 第三方产品分析报告

      ✅ COA系统入驻 | 共享模式

      主要参考文献


      1: ABBOTT LG. Neurodermatoses and captodiame. Aust J Dermatol. 1960 Jun;5:187-90. doi: 10.1002/14651858.CD011481.pub2. Review.

      合成参考文献


      摘要:Archives Internationales de Pharmacodynamie et de Therapie., 136(440), 1962 []
      摘要:Arzneimittel-Forschung. Drug Research., 8(154), 1958 []
      摘要:Journal of Pharmacology and Experimental Therapeutics., 108(201), 1953 []
      摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664
      📝 需求与反馈
      尽可能描述清楚需求与问题信息
      ×

      通知