CAS: 476-70-0; (6As)-1,10-Dimethoxy-6-Methyl-5,6,6A,7-Tetrahydro-4H-Dibenzo[de,G]Quinoline-2,9-Diol

该化合物是源于以各种生物活动闻名的果树树(Peumus goldus)树皮的藻类,其特点是分子式,典型包括碳,氢,氮和氧原子,反映其复杂结构;该化合物具有手性,其(+)名称表明其特定的光学活动. (+)-Boldine因其抗氧化剂,抗炎和肝保护特性而得到承认,因此对药理研究感兴趣.它已被研究潜在的治疗用途,特别是在肝脏健康和消化紊乱方面.此外,(+)-Boldine可能与各种生物途径相互作用,影响酶活动和细胞过程.其溶性特征可能各不相同,其有机溶剂中往往比水中更溶解,而水是许多藻类中的常见特征.

结构式图片

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CAS号50-00-0 甲醛 | CAS号64-18-6 甲酸 | CAS号475-81-0 (+)-海罂粟碱

合成工艺路线路线简述

    聚合甲醛,甲酸,Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于水体系中,化学反应生成 波尔定碱
    参考文献:Nakasato; Nomura,Chemical And Pharmaceutical Bulletin,1959,Vol. 7,P. 780,784
    标题:Nakasato; Nomura,Chemical And Pharmaceutical Bulletin,1959,Vol. 7,P. 780,784

    海关参考信息

    专利信息


    专利号:US-2023279170-A1
    优先权日:2022-03-02
    标 题:Chiral-substituted poly-n-vinylpyrrolidinones and complexes with bimetallic nanoclusters and uses thereof
    发明人:HUA DUY H
    权利人:UNIV KANSAS STATE
    摘要:Synthesis of chiral polyvinylpyrrolidinone (CSPVP) compounds, complexes of CSPVP with a core species, such as a bimetallic nanocluster catalyst, and selective C—H bond oxidation reactions utilizing such complexes are disclosed. These reaction products can be used as reagents in the synthesis of complex organic molecules, such as bioactive products, and C—H bond oxidation of complex molecules including various drugs and natural products.

    专利号:US-12240810-B2
    优先权日:2019-02-04
    标 题:Chiral-substituted poly-N-vinylpyrrolidinones and complexes with bimetallic nanoclusters and uses thereof in asymmetric oxidation reactions
    发明人:HUA DUY H
    权利人:UNIV KANSAS STATE; KANSAS STATE UNIV RESEARCH
    摘要:Chiral polyvinylpyrrolidinone (CSPVP), complexes of CSPVP with a core species, such as a bimetallic nanocluster catalyst, and enantioselective oxidation reactions utilizing such complexes are disclosed. The catalytic complexes have exhibited the ability to achieve reaction products have a very high degree of optical purifies. These reaction products can be used as reagents in the synthesis of complex organic molecules, such as bioactive products, and C—H bond oxidation of complex molecules including various drugs and natural products.

    专利号:US-10258561-B2
    优先权日:2013-02-28
    标 题 :Cosmetic composition containing a brown alga extract, a yeast extract and ascorbic acid
    发明人:FRANCHI JOCELYNE; RENIMEL ISABELLE; NEVEU MICHELE; GORZELANCZYK VALERIE; MANIGUET SABRINA
    权利人:LVMH RECH
    摘要:The combination of active agents of the invention for which a synergistic effect with regard to the synthesis of the procollagen I has been shown also produces an advantageous effect with regard to other markers of aging.

    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

    专利号:CN-105566398-A
    优先权日:2015-12-31
    标 题:A kind of highly active oxidized aporphine-rhodium (III) complex and its synthesis method and application

    专利号:CN-115612114-A
    优先权日:2021-07-14
    标 题:Method and application of copolymer film and its enzymatic self-assembly synthesis
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    主要参考文献


    1: Muthna D, Cmielova J, Tomsik P, Rezacova M. Boldine and related aporphines: from antioxidant to antiproliferative properties. Nat Prod Commun. 2013 Dec;8(12):1797-800. Review.

    合成参考文献


    参考文献:10.4103/0974-8490.81957
    摘要:Wong SK, Lim YY, Abdullah NR, Nordin FJ. Antiproliferative and phytochemical analyses of leaf extracts of ten Apocynaceae species. Pharmacognosy Res. 2011 Apr;3(2):100–6.
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