专利号:WO-2004075874-A1 优先权日:2003-02-28 标题 :Method for treatment and prevention of acute and chronic pseudomonas aeruginosa airway infections with inhalable macrolides 发明人:MENEKSE OKTAY 权利人:ANBICS PATENTS LICENCES AG; MENEKSE OKTAY 摘要:Macrolides, in particular azalides such as azithromycin, are suited for the treatment or prevention of acute or chronic P. aeruginosa infections of the airways by inhalaÂtion. The mechanism of action is the inhibition of the quoÂrum sensing of P. aeruginosa, in particular the impediment of the las and rhl quorum sensing systems synthesis and the impediment of the synthesis of the autoinducers N-[3-oxodoÂ1o decanoyl]-L-homoserine lactone and N-butyrylhomoserine lacÂtone. This allows for inhalation treatments of P. aerugi-nosa infections at non-inhibiting concentrations of the macrolide.
专利号:US-RE37543-E 优先权日:1996-08-13 标 题:DNA sequence useful for the production of polyhydroxyalkanoates 发明人:KRUEGER NIELS; STEINBUECHEL ALEXANDER 权利人:MONSANTO CO 摘要:A genomic fragment harboring the gene phaG was cloned by phenotype complementation of Pseudomonas putida KT2440 mutants, defective in the polyhydroxyalkanoic acid (PHA) synthesis via de novo fatty acid biosynthesis but not affected in PHA biosynthesis via fatty acid beta-oxidation. The 885-bp phaG gene encodes a protein of 295 amino acids with a molecular weight of 33.876 Da. The transcriptional induction of phaG could be observed under conditions of PHA synthesis via de novo fatty acid biosynthesis whereas no induction was detected under conditions which favor PHA synthesis via fatty acid degradation by beta-oxidation. The phaG gene is useful for the production of PHAs in bacteria and plants.
专利号:US-2022403431-A1 优先权日:2020-02-14 标 题 :Glycominimized bacterial host cells 发明人:BEAUPREZ JOERI; DE MAESENEIRE SOFIA; SNOECK NICO 权利人:INBIOSE NV 摘要:This disclosure is in the technical field of synthetic biology and metabolic engineering. The disclosure provides engineered viable bacteria having a reduced or abolished synthesis of poly-N-acetyl-glucosamine (PNAG), Enterobacterial Common Antigen (ECA), cellulose, colanic acid, core oligosaccharides, Osmoregulated Periplasmic Glucans and Glucosylglycerol (O), glycan, and trebalose. The disclosure further provides methods for the production of bioproduct by the viable bacteria and uses thereof. Furthermore, the disclosure is in the technical field of fermentation of metabolically engineered microorganisms producing bioproduct.
专利号:US-2018066297-A1 优先权日:2015-02-19 标 题 :Rhamnolipid synthesis 发明人:HAAS THOMAS; BÜLTER THOMAAS; BUCHHOLZ STEFAN; BECK SIMON 权利人:HAAS THOMAS; BUELTER THOMAS; BUCHHOLZ STEFAN; BECK SIMON; EVONIK DEGUSSA GMBH 摘要:There is provided a method of producing at least one rhamnolipid comprising:n (a) contacting a recombinant cell with a medium containing a carbon source; wherein the recombinant cell has been genetically modified such that, compared to the wild-type of the cell, the cell has an increased activity of at least one of the enzymes E 1 , E 2 and E 3 , wherein the enzyme E 1 is an α/β hydrolase (RHIA), the enzyme E 2 is a rhamnosyltransferase I (RHIB) and the enzyme E 3 is a rhamnosyltransferase II (RHIC), and wherein the carbon source is an alkane and/or alkanoic acid comprising 6 to 10 carbon atoms.
专利号:CA-2857947-A1 优先权日:2011-03-15 标题 :Facile synthesis of graphene, graphene derivatives and abrasive nanoparticles and their various uses, including as tribologically-beneficial lubricant additives
专利号:BR-112013023547-A2 优先权日:2011-03-15 标题 :easy synthesis of graphene, graphene derivatives and abrasive nanoparticles and their various uses, including as tribologically beneficial lubricant additives
参考文献:10.1271/bbb.63.946 摘要:LEE Y, LEE SY, YANG J. Production of Rhamnolipid Biosurfactant by Fed-batch Culture ofPseudomonas aeruginosaUsing Glucose as a Sole Carbon Source. Bioscience, Biotechnology, and Biochemistry. 1999 Jan;63(5):946–7. doi: 10.1271/bbb.63.946.