CAS: 40290-32-2; 1,2-Dipalmitoyl-Rac-Glycerol

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三棕榈酸甘油酯 Glyceroltripalmitate 555-44-2
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1,2-二棕榈酰-3-O-苄基-Rac-甘油 1,2-Di-O-Palmitoyl-3-O-Benzyl-Rac-Glycerol 69176-47-2

📜甘油棕榈酸酯置于吡啶,4-二甲氨基吡啶,盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺体系中,用 甲醇,二氯甲烷,氯仿 作为反应溶剂,化学反应 20.0H,反应生成 1,2-二棕榈酰-Rac-丙三醇
参考文献:Lipidomics Characterization Of Biosynthetic And Remodeling Pathways Of Cardiolipins In Genetically And Nutritionally Manipulated Yeast Cells
标题:Lipidomics Characterization Of Biosynthetic And Remodeling Pathways Of Cardiolipins In Genetically And Nutritionally Manipulated Yeast Cells
摘要:Cardioipins (Cls) Are Unique Tetra-Acylated Phospholipids Of Mitochondria And Define The Bioenergetics,And Regulatory Functions Of These Organelles. An Unresolved Paradox Is The High Uniformity Of Cl Molecular Species (Tetra-Linoleoyl-Cl) In The Heart,Liver,And Skeletal Muscles In Contrast To Their High Diversification In The Brain. Here,We Combined Liquid Chromatography Mass-Spectrometry-Based Phospholipidomics With Genetic,And Nutritional Manipulations To Explore Cls Biosynthetic Vs Postsynthetic Remodeling Processes In S. Cerevisiae Yeast Cells. By Applying The Differential Phospholipidomics Analysis,We Evaluated The Contribution Of Cld1 (Cl-Specific Phospholipase A) And Taz1 (Acyl-Transferase) As The Major Regulatory Mechanisms Of The Remodeling Process. We Further Established That Nutritional "Pressure" By High Levels Of Free Fatty Acids Triggered A Massive Synthesis Of Homoacylated Molecular Species In All Classes Of Phospholipids,Resulting In The Preponderance Of The Respective,Homoacylated Cls. We Found That Changes In Molecular Speciation Of Cls Induced By Exogenous C18-Fatty Acid'S,(C18:1 And C18:2) Wild-Type (Wt) Cells Did Not occur In Any Of The Remodeling Mutant Cells,Including Dd1 Delta,Taz1 Delta,And Dd1 Delta Taz1 Delta. Interestingly,Molecular Speciation Of Cls In Wt And Double Mutant Cells Dd1 Delta Taz1 Delta Was Markedly Different. Given That The Bioenergetics Functions Are Preserved In The,Double Mutant,This Suggests That The Accumulated Mlcl-Rather Than The Changed Cl Speciation-Are The Likely Major Contributors To The Mitochondrial Dysfunction In Taz1 Delta Mutant Cells (Also Characteristic Of Barth Syndrome): Biochemical Studies Of Cld1 Specificity And Computer Modeling Confirmed The Hydrolytic Selectivity Of The Enzyme Toward C16-Cl Substrates And The Preservation Of C18:1-Containing Cl Species.
DOI:10.1021/acschembio.6B00995