专利号:US-9029504-B2 优先权日:2009-03-12 标题 :Fluorene compound 发明人:TAKAHASHI DAISUKE 权利人:AJINOMOTO KK 摘要:Particular compounds having a fluorene skeleton are superior in broad utility and stability, as a protecting reagent for liquid phase synthesis of amino acids and/or peptides.
专利号:US-8927569-B2 优先权日:2007-07-19 标 题 :Macrocyclic compounds as antiviral agents 发明人:HARPER STEVEN; SUMMA VINCENZO; LIVERTON NIGEL J; MCCAULEY JOHN A; BUTCHER JOHN W; DI FILIPPO MARCELLO; DI FRANCESCO MARIA EMILIA; FERRARA MARCO; ROMANO JOSEPH J; RUDD MICHAEL T 权利人:HARPER STEVEN; SUMMA VINCENZO; LIVERTON NIGEL J; MCCAULEY JOHN A; BUTCHER JOHN W; DI FILIPPO MARCELLO; DI FRANCESCO MARIA EMILIA; FERRARA MARCO; ROMANO JOSEPH J; RUDD MICHAEL T; MERCK SHARP & DOHME 摘要:A class of macrocyclic compounds of formula (I), wherein R 1 , R 3 , R 4 , R a , R b , A, Z, Y, X, M, W, n and m are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes 5 for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection. Formula (I):
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[参考文献]: Guang-Wei Zhang, Et Al. Supramolecular Luminescence From Oligofluorenol-Based Supramolecular Polymer Semiconductors. Int J Mol Sci. 2013 Nov 13;14(11):22368-79.
合成参考文献
摘要:Chiba, S.; Narasaka, K., Science of Synthesis Knowledge Updates, (2011) 4, 482. 摘要:Bietti, M.; Dénès, F., Science of Synthesis, (2021) , 531. 摘要:Khandelia, T.; Ghosh, S.; Patel, B. K., Science of Synthesis: Cross-Dehydrogenative Coupling, (2023) nan, 177.